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Diabetes mellitus und andere Störungen des Kohlenhydratstoffwechsels

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Book cover Pathophysiologie

Part of the book series: Springer Lehrbuch ((SLB))

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Zusammenfassung

Ein 58 jähriger Transportarbeiter wird nach Beginn der Frühschicht um 6:20 Uhr mit heftigen links-thorakalen Schmerzen als Notfall eingeliefert. Im EKG werden ST-Strecken-Hebungen in den Abteilungen II, III, aVF festgestellt, und eineinhalb Stunden nach Schmerzbeginn wird eine thrombolytische Therapie durchgeführt. Der Patient hat nie geraucht, war übergewichtig (92 kg, 179 cm, Body-Mass-Index 28,7 kg/m2), hatte erhöhte Triglyzeridwerte (270 mg/dl), ein geringfügig erhöhtes Cholesterin (245 mg/dl) und am Aufnahmetag eine Blutzuckerkonzentration von 260 mg/dl. Der Vater des Patienten litt an einem Typ-2-Diabetes und verstarb 72 jährig an einem Myokardinfarkt. Die Untersuchungen ergaben einen HbAic-Wert von 11,0%, Urinuntersuchungen auf Ketonkörper ergaben negative Befunde oder allenfalls Spuren.

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Literatur

  1. Alberti KGMM, Zimmet P, DeFronzo RA (1997) International Textbook of Diabetes mellitus, vol 1 and 2. John Wiley & Sons Ltd.,Chichester, UK

    Google Scholar 

  2. Atkinson MA, MacLaren NK The pathogenesis of insulindependent diabetes mellitus. N Engl J Med 331:1428–1432

    Google Scholar 

  3. Baynes JW, Thorpe SR (1996) The role of oxidative stress in diabetic complications. Curr Opinion Endocrinol 3:277–284

    Article  Google Scholar 

  4. Bell DSH, Grizzle WE, Dunlap NE (1995) Nesidoblastosis causing reversal of insulin-dependent diabetes and development of hyperinsulinemic hypoglycemia. Diabetes Care 8:1379–1380

    Google Scholar 

  5. Berger M (1995) Diabetes mellitus. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  6. Brownlee M (1996) Advanced glycation end products in dia- betic complications. Curr Opinion Endocrinol 3:291–297

    Article  CAS  Google Scholar 

  7. Burg MB, Kador PF (1988) Sorbitol, osmoregulation, and the complications of diabetes. J Clin Invest 81:635–640

    Article  PubMed  CAS  Google Scholar 

  8. Chen Y-T, Burchell A (1995) Glycogen Storage Diseases. In: Scriver CR, Beaudet AL, Sly WS et al. (eds) The Metabolie and Molecular Bases of Inherited Disease, vol I. McGraw-Hill, Inc., New York, pp 935–965

    Google Scholar 

  9. Committee Report (1997) Report of the expert committee on the diagnosis and Classification of diabetes. Diabetes Care 21:S5-S22

    Google Scholar 

  10. Creutzfeldt W, Nauck M (1992) Gut hormones and diabetes mellitus. Diabetes/Metabolism Rev 8:149–177

    Article  CAS  Google Scholar 

  11. Cryer PE (1992) Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. A vicious cycle (Perspectives in Diabetes). Diabetes 41:255–260

    Article  PubMed  CAS  Google Scholar 

  12. Cryer PE, Fisher JN, Shamoon H (1994) Hypoglycaemia. Diabetes Care 17:734–755

    PubMed  CAS  Google Scholar 

  13. De Meyts P, Christoffersen CT, Tornquist H, Seedorf K (1996) Insulin reeeptors and insulin actions. Curr Opinion Endocrinol 3:369–377

    CAS  Google Scholar 

  14. Eisenbarth GS (1986) Type 1 diabetes mellitus. A chronic autoimmune disease (seminars in medicine). N Engl J Med 314:1360–1368

    Article  PubMed  CAS  Google Scholar 

  15. Ferrannini E, Natali A, Pell P, Cavallo-Perin P, Lalic N, Mingrone G (1997) Insulin resistance and hypersecretion in obesity. J Clin Invest 100:1166–1173

    Article  PubMed  CAS  Google Scholar 

  16. Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA (1986) Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. J Clin Invest 77:1525–1532

    Article  PubMed  CAS  Google Scholar 

  17. Gitzelmann R, Steinmann B, Van den Berghe G (1995) Disorders of Fructose Metabolism. In: Scriver CR, Beaudet AL, Sly WS et al. (eds) The Metabolie and Molecular Bases of Inherited Disease, vol I. McGraw-Hill, Inc., New York, pp 905–934

    Google Scholar 

  18. Kelley D, Mitrakou A, Marsh H et al. (1988) Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest 81:1563–1571

    Article  PubMed  CAS  Google Scholar 

  19. Merimee TJ, Tyson JE (1977) Hypoglycemia in man. Pathologic and physiologic variants. Diabetes 26:161–165

    Article  PubMed  CAS  Google Scholar 

  20. Mitrakou A, Ryan C, Veneman T et al. (1991) Hierarchy of glycemic thresholds for counterregulatory hormone secretion, Symptoms, and cerebral dysfunetion. Am J Physiol 260 (Endocrinol Metab 23):E67-E 74

    PubMed  CAS  Google Scholar 

  21. Mogensen CE, Christensen CK, Vittinghus E (1983) The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy. Diabetes 32 (Suppl 2):64–78

    PubMed  Google Scholar 

  22. Nauck MA (1998) Physiology and pathophysiology of endocrine pancreatic secretion. In: Beger HG, Warshaw AL, Büchler MW et al. (eds) The pancreas, vol 1. Blackwell Science Ltd., Oxford London Edinburgh Maiden Carlton Paris, pp 101–137

    Google Scholar 

  23. Nauck MA, Baum F, Seidensticker F, Røder M, Dinesen B, Creutzfeldt W (1997) A hyperinsulinaemic, sequentially euand hypoglycaemic clamp test to characterize autonomous insulin secretion in patients with insulinoma. Eur J Clin Invest 27:109–115

    Article  PubMed  CAS  Google Scholar 

  24. Polonsky KS, Given BD, Hirsch LJ et al. (1988) Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318: 1231–1239

    Article  PubMed  CAS  Google Scholar 

  25. Polonsky KS, Given BD, van Cauter E (1988) Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 81: 442–448

    Article  PubMed  CAS  Google Scholar 

  26. Porte DJ (1991) ß-cells in Type II diabetes mellitus (Banting lecture 1990). Diabetes 40:166–180

    Article  PubMed  Google Scholar 

  27. Reaven GM (1988) Role of insulin resistance in human disease (Banting lecture 1990). Diabetes 37:1595–1607

    Article  PubMed  CAS  Google Scholar 

  28. Rizza RR, Mandarino LJ, Gerich JE (1981) Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol 240:E 630-E639

    Google Scholar 

  29. Rossetti L, Giaccari A, DeFronzo RA (1990) Glucose toxicity. Diabetes Care 13: 610–630

    Article  PubMed  CAS  Google Scholar 

  30. Segal S, Berry G (1995) Disorders of Galactose Metabolism. In: Scriver CR, Beaudet AL, Sly WS et al. (eds) The Metabolie and Molecular Bases of Inherited Disease, vol I. McGraw-Hill, Inc., New York, pp 967–1000

    Google Scholar 

  31. Service FJ (1995) Hypoglycemic disorders. N Engl J Med 332:1144–1152

    Article  PubMed  CAS  Google Scholar 

  32. The Diabetes Control and Complication Trial Research group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977–968

    Article  Google Scholar 

  33. Turner RC, Oakley NW, Nabarro JDN (1971) Control of basal insulin secretion, with special reference to the diagnosis of insulinomas. British Medical Journal 2:132–135

    Article  PubMed  CAS  Google Scholar 

  34. Yki-Järvinen (1995) Role of insulin resistance in the pathogenesis of NIDDM. Diabetologia 38:1378–1388

    Article  PubMed  Google Scholar 

  35. Yki-Järvinen H (1997) MODY genes and mutations in hepatocyte nuclear factors. The Lancet 349: 516–517

    Article  Google Scholar 

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Authors
  1. M. A. Nauck
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© 2000 Springer-Verlag Berlin Heidelberg

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Nauck, M.A. (2000). Diabetes mellitus und andere Störungen des Kohlenhydratstoffwechsels. In: Pathophysiologie. Springer Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57115-2_24

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  • DOI: https://doi.org/10.1007/978-3-642-57115-2_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63004-0

  • Online ISBN: 978-3-642-57115-2

  • eBook Packages: Springer Book Archive

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