The Tumor Necrosis Factor-α Converting Enzyme

  • J. D. Becherer
  • M. H. Lambert
  • R. C. Andrews
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 140)


Tumor necrosis factor (TNF)-α is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages (VASSALLI 1992). Originally thought to be a selective anti-tumor agent (OLD 1985) and a contributor to cachexia in cancer patients (BEUTLER and CERAMI 1988), this protein, along with interleukin (IL)-1α, is recognized as a major inflammatory cytokine. Moreover, the production of TNF-α is not restricted to monocytes and macrophages. Other cellular sources of TNF-α include lymphocytes, mast cells, polymorphonuclear cells, astrocytes and microglial cells (SUNG et al. 1988; SAWADA et al. 1989; GORDON and GALLI 1990; DJEU et al. 1990; CHUNG and BENVENISTE 1990). Increasing evidence suggests that overproduction of TNF- αis a major contributor to diverse pathologies such as septic shock, graft rejection, human immunodeficiency virus (HIV) infection and rheumatoid arthritis (RA) (TRACY et al. 1986; PIGUET et al. 1987; PETERSON et al. 1992; WILLIAMS et al. 1992).


Acetohydroxamic Acid Disintegrin Domain Cysteine Switch Hydroxamate Inhibitor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • J. D. Becherer
    • 1
  • M. H. Lambert
    • 1
  • R. C. Andrews
    • 1
  1. 1.Glaxo Wellcome Inc.Research Triangle ParkUSA

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