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Nitric Oxide pp 329–361Cite as

The Role of Nitric Oxide in Kidney Function

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Part of the Handbook of Experimental Pharmacology book series (HEP,volume 143)

Abstract

There is increasing evidence that nitric oxide (NO) is one of the most important paracrine modulators and mediators in the control of renal functions, such as overall and regional renal blood flow (RBF), renal autoregulation, glomerular filtration, renin secretion and salt excretion. NO also plays an important role in the pathogenesis of several renal disease states, such as diabetic nephropathy, inflammatory glomerular disease, acute renal failure in septic shock, chronic renal failure and nephrotoxicity of drugs, conveying both beneficial effects via its hemodynamic functions and detrimental effects via its cytotoxicity when produced in large amounts by inducible nitric oxide synthase (iNOS). The extensive literature on these pathophysiological functions of NO will not be covered here, and the reader is referred to the pertinent chapters (Chaps. 18, 21, 22, 23) for discussion.

Keywords

  • Nitric Oxide
  • Renin Release
  • Renin Secretion
  • Afferent Arteriole
  • Thick Ascend Limb

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  1. E. Hackenthal
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  1. Department of Pharmacology and Toxicology, Karl-Franzens-University of Graz, Universitätsplatz 2, 8010, Graz, Austria

    Universitäts-Professor Dr. Bernd Mayer

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Hackenthal, E. (2000). The Role of Nitric Oxide in Kidney Function. In: Mayer, B. (eds) Nitric Oxide. Handbook of Experimental Pharmacology, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57077-3_15

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  • DOI: https://doi.org/10.1007/978-3-642-57077-3_15

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