Bausteine und Organisationsformen des Bindegewebes

  • Winfried Mohr


Das Bindegewebe ist eine „Gewebsform, die die Organe mit der Nachbarschaft verbindet und deren innere und äußere Form festigt“ [316]. Eine Vorstellung zum Aufbau dieses „fibrösen Systems“ konzipierte um 1800 Bichat [20]: „In der hier folgenden Tafel kann man die von mir aufgestellte Eintheilung der fibrösen Organe mit einem Blick übersehen.


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  1. 1.
    Adachi E, Hayashi T (1986) In vitro formation of hybrid fibrils of type V collagen and type I collagen. Limited growth of type I collagen into thick fibrils by type V collagen. Connect Tissue Res 14:257–266PubMedGoogle Scholar
  2. 2.
    Aigner T, Frischholz S, Dertinger S, Beier F, Girkontaité I, von der Mark K (1997) Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias. Histochem Cell Biol 107:435–440PubMedGoogle Scholar
  3. 3.
    Aigner T, Neureiter D, Völker U, Belke J, Kirchner T (1998) Epithelial-mesenchymal transdifferentiation and extracellular matrix gene expression in pleomorphic adenomas of the parotid salivary gland. J Pathol 186:178–185PubMedGoogle Scholar
  4. 4.
    Aigner T, Oehler S, Niedobitek HG, Fassbender G, Kirchner T (1998) Eisenablagerungen, Zellpopulationen und proliferative Aktivität in der pigmentierten villonodulären Synovitis des Kniegelenkes. Verh Dtsch Ges Pathol 82:327–331PubMedGoogle Scholar
  5. 5.
    Albelda SM, Buck CA (1990) Integrins and other cell adhesion molecules. FASEB J 4:2868–2880PubMedGoogle Scholar
  6. 6.
    Alini M, Carey D, Hirata S, Grynpas MD, Pidoux I, Poole AR (1994) Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: Arrest of type X collagen synthesis and net loss of collagen when calcification is initiated. J Bone Miner Res 9:1077–1087PubMedGoogle Scholar
  7. 7.
    Althoff J, Richter K-D, Quint P (1997) Können Chondrocyten zu knochenbildenden Zellen differenzieren?. Osteologie (Suppl 1) 6:28 (Abstr)Google Scholar
  8. 8.
    Anderson JC (1992) Biochemical basis of connective tissue disease. In: Gardner DL (ed) Pathological basis of the connective tissue diseases. Edward Arnold, London Melbourne Auckland, pp 173–226Google Scholar
  9. 9.
    Apte SS, Athanasou NA (1992) An immunohistological study of cartilage and synovium in primary synovial chondromatosis. J Pathol 166:277–281PubMedGoogle Scholar
  10. 10.
    Arias JL, Fernandez MS, Dennis JE, Caplan AI (1991) Collagens of the chicken eggshell membranes. Connect Tissue Res 26:37–45PubMedGoogle Scholar
  11. 11.
    Athanasou NA (1995) Synovial macrophages. Ann Rheum Dis 54:392–394PubMedGoogle Scholar
  12. 12.
    Aydelotte MB, Greenhill RR, Kuettner KE (1988) Differences between sub-populations of cultured bovine articular chondrocytes. II. Proteoglycan metabolism. Connect Tissue Res 18:223–234PubMedGoogle Scholar
  13. 13.
    Baitsell GA (1915) The origin and structure of a fibrous tissue which appears in living cultures of adult frog tissues. J Exp Med 21:455–479PubMedGoogle Scholar
  14. 14.
    Baitsell GA (1917) A study of the clotting of the plasma of frog’s blood and the transformation of the clot into a fibrous tissue. Am J Physiol 44:109–131Google Scholar
  15. 15.
    Baló J, Banga I (1950) The elastolytic activity of pancreatic extracts. Biochem J 46:384–387PubMedGoogle Scholar
  16. 16.
    Beckert R, Dominok GW (1969) Der histologisch nachweisbare alternsabhängige Fettgehalt in den Knorpelge-websarten beim Menschen. Z Alternsforsch 21:333–345PubMedGoogle Scholar
  17. 17.
    Beranek JT, Masseyeff R (1986) Hyperplastic capillaries and their possible involvement in the pathogenesis of fibrosis. Histopathology 10:543–546PubMedGoogle Scholar
  18. 18.
    Beranek JT, Hsi BL, Ortonne JP (1985) Occurrence of factor VIII-related antigen positive cells in perivascular infiltrates of venous stasis dermatitis. Br J Dermatol (Suppl 28) 113:128–132Google Scholar
  19. 19.
    Bianco P, Fisher LW, Young MF, Termine JD, Gehron Robey P (1990) Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem 38:1549–1563PubMedGoogle Scholar
  20. 20.
    Bichat X (1803) Allgemeine Anatomie angewandt auf die Physiologie und Arzneywisenschaft. Übersetzt von C. H. Pfaff. 2. Theil, 1. Abtheilung. Siegfried Lebrecht Crusius, Leipzig, S 116–118Google Scholar
  21. 21.
    Birk DE, Fitch JM, Babiarz JP, Doane KJ, Linsenmayer TF (1990) Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter. J Cell Sci 95:649–657PubMedGoogle Scholar
  22. 22.
    Biselli R, Ferlini C, Fattorossi A, Boldrini R, Bosman C (1996) Inflammatory myofibroblastic tumor (inflammatory pseudotumor). Cancer 77:778–784PubMedGoogle Scholar
  23. 23.
    Bonaldo P, Russo V, Bucciotti F, Doliana R, Colombatti A (1990) Structural and functional features of the α3 chain indicate a bridging role for chicken collagen VI in connective tissues. Biochemistry 29:1245–1254PubMedGoogle Scholar
  24. 24.
    Brooks JJ (1986) The significance of double phenotypic patterns and markers in human sarcomas. A new model of mesenchymal differentiation. Am J Pathol 125:113–123PubMedGoogle Scholar
  25. 25.
    Brown RA, Jones KL (1990) The synthesis and accumulation of fibronectin by human articular cartilage. J Rheumatol 17:65–72PubMedGoogle Scholar
  26. 26.
    Bruckner-Tuderman L, Schnyder UW, Winterhalter KH, Bruckner P (1987) Tissue form of type VII collagen from human skin and dermal fibroblasts in culture. Eur J Biochem 165:607–611PubMedGoogle Scholar
  27. 27.
    Bruns RR (1984) Beaded filaments and long-spacing fibrils: Relation to type-VI-collagen. J Ultrastruct Res 89:136–145PubMedGoogle Scholar
  28. 28.
    Bruns RR, Press W, Engvall E, Timple R, Gross J (1986) Type VI collagen in extracellular, 100-nm periodic filaments and fibrils: Identification by immunoelectron microscopy. J Cell Biol 103:393–404PubMedGoogle Scholar
  29. 29.
    Burgeson RE (1982) Genetic heterogeneity of collagens. J Invest Dermatol (Suppl 1) 79:25s-30sGoogle Scholar
  30. 30.
    Burgeson RE, Morris NP, Murray LW, Duncan KG, Keene DR, Sakai LY (1985) The structure of type VII collagen. Ann NY Acad Sci 460:47–57PubMedGoogle Scholar
  31. 31.
    Burmester G, Menche D, Merryman P, Klein M, Winchester R (1983) Application of monoclonal antibodies to the characterization of cells eluted from human articular cartilage. Expression of Ia antigens in certain diseases and identification of an 85-Kd cell surface molecule accumulated in the pericellular matrix. Arthritis Rheum 26:1187–1195PubMedGoogle Scholar
  32. 32.
    Burmester GR, Locher P, Koch B, Winchester RJ, Dimitriu-Bona A, Kalden JR, Mohr W (1983) The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens. Rheumatol Int 3:173–181PubMedGoogle Scholar
  33. 33.
    Burton-Wurster N, Horn VJ, Lust G (1988) Immunohistochemical localization of fibronectin and chondronectin in canine articular cartilage. J Histochem Cytochem 36:581–588PubMedGoogle Scholar
  34. 34.
    Busiek DF, Ross FP, McDonnell S, Murphy G, Matrisian LM, Welgus HG (1992) The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes. J Biol Chem 267:9087–9092PubMedGoogle Scholar
  35. 35.
    Caldini EG, Caldini N, De-Pasquale V, Strocchi R, Guizzardi S, Ruggeri A, Montes GS (1990) Distribution of elastic system fibres in rat tail tendon and its associated sheaths. Acta Anat 139:341–348PubMedGoogle Scholar
  36. 36.
    Campbell IK, Novak U, Cebon J, Layton JE, Hamilton JA (1991) Human articular cartilage and chondrocytes produce hemopoietic colony-stimulating factors in culture in response to IL-1. J Immunol 147:1238–1246PubMedGoogle Scholar
  37. 37.
    Cancedda R, Descalzi-Cancedda F, Castagnola P (1995) Chondrocyte differentiation. Int Rev Cytol 159:265–358PubMedGoogle Scholar
  38. 38.
    Chain E, Duthie ES (1940) Identity of hyaluronidase and spreading factor. Br J Exp Pathol 21:324–338Google Scholar
  39. 39.
    Chevalier X, Groult N, Larget-Piet B, Zardi L, Hornebeck W (1994) Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 37:1013–1022PubMedGoogle Scholar
  40. 40.
    Chung KS, Park HH, Ting K, Takita H, Apte SS, Kuboki Y, Nishimura I (1995) Modulated expression of type X collagen in the Meckel’s cartilage with different developmental fates. Dev Biol 170:387–396PubMedGoogle Scholar
  41. 41.
    Cole AA, Chubinskaya S, Schumacher B et al. (1996) Chondrocyte matrix metalloproteinase 8. Human articular chondrocytes express neutrophil collagenase. J Biol Chem 271:11023–11026PubMedGoogle Scholar
  42. 42.
    Colombatti A, Bonaldo P (1987) Biosynthesis of chick type VI collagen. II. Processing and secretion in fibroblasts and smooth muscle cells. J Biol Chem 262:14461–14466PubMedGoogle Scholar
  43. 43.
    Colombatti A, Bonaldo P (1991) The superfamily of proteins with von Willebrand factor type A-like domains: One theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms. Blood 77:2305–2315PubMedGoogle Scholar
  44. 44.
    Comerford FR, Etwebi AB (1995) Localisation of latex particles in the rat knee joint. Ann Rheum Dis 54:436 (Abstr)Google Scholar
  45. 45.
    Conway EM, Nowakowski B (1993) Biologically active thrombomodulin is synthesized by adherent synovial fluid cells and is elevated in synovial fluid of patients with rheumatoid arthritis. Blood 81:726–733PubMedGoogle Scholar
  46. 46.
    Cox RW, Peacock MA (1977) The fine structure of developing elastic cartilage. J Anat 123:283–296PubMedGoogle Scholar
  47. 47.
    Cutolo M, Sulli A, Barone A, Seriolo B, Accardo S (1993) Macrophages, synovial tissue and rheumatoid arthritis. Clin Exp Rheumatol 11:331–339PubMedGoogle Scholar
  48. 48.
    Dahlqvist A, Olsson I, Nordén Å (1965) The periodate-Schiff reaction: Specificity, kinetics, and reaction products with pure substrates. J Histochem Cytochem 13:423–430PubMedGoogle Scholar
  49. 49.
    Damiano V, Tsang A, Kucich U, Weinbaum G, Rosenbloom J (1981) Immuno electron microscopic studies on cells synthesizing elastin. Connect Tissue Res 8:185–188PubMedGoogle Scholar
  50. 50.
    Desmet VJ (1986) Hyperplastic capillaries and their possible involvement in the pathogenesis of fibrosis. Histopathology 10:546–551Google Scholar
  51. 51.
    Dettmer N (1956) Elektronenmikroskopische Untersuchungen am elastischen Fasersystem des Ligamentum nuchae. Z Zellforschg 45:265–279Google Scholar
  52. 52.
    Diamond JR, van Goor H, Ding G, Engelmyer E (1995) Myofibroblasts in experimental hydronephrosis. Am J Pathol 146:121–129PubMedGoogle Scholar
  53. 53.
    Dietz HC, Ramirez F, Sakai LY (1994) Marfan’s syndrome and other microfibrillar diseases. Adv Hum Genet 22:153–186PubMedGoogle Scholar
  54. 54.
    Dodge GR, Poole AR (1989) Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in expiants of bovine articular cartilage cultured with interleukin 1. J Clin Invest 83:647–661PubMedGoogle Scholar
  55. 55.
    Doljanski L, Roulet F (1933) Studien über die Entstehung der Bindegewebsfibrille. Virchows Arch 291:260–320Google Scholar
  56. 56.
    Donner LR, Trompler RA, White RR (1996) Progression of inflammatory myofibroblastic tumor (inflammatory pseudotumor) or soft tissue into sarcoma after several recurrences. Hum Pathol 27:1095–1098PubMedGoogle Scholar
  57. 57.
    Dreher R, Görnert C, Macholt U, Rohrbach B, Federlin K (1981) Klassifikation der synovitischen Reaktionstypen bei rheumatoider Arthritis aufgrund zellkinetisch-morphologischer Befunde bei der experimentellen Immunarthritis. Immun Infekt 9:204–212PubMedGoogle Scholar
  58. 58.
    Dubick MA, Rucker RB, Cross CE, Last JA (1981) Elastin metabolism in rodent lung. Biochem Biophys Acta 672:303–306PubMedGoogle Scholar
  59. 59.
    Ebner Vv (1896) Die Chorda dorsalis der niederen Fische und die Entwicklung des fibrillären Bindegewebes. Z Wiss Zool 62:469–526Google Scholar
  60. 60.
    Editorial (1989) Fibronectins and vitronectin. Lancet 1:474–476Google Scholar
  61. 61.
    Edwards JCW (1995) Synovial intimai fibroblasts. Ann Rheum Dis 54:395–397PubMedGoogle Scholar
  62. 62.
    Emonard H, Hornebeck W (1997) Binding of 92 kDa and 72 kDa progelatinases to insoluble elastin modulates their proteolytic activation. Biol Chem 378:265–271PubMedGoogle Scholar
  63. 63.
    Engel J, Furthmayr H, Odermatt E, von der Mark H, Aumailley M, Fleischmajer R, Timpl R (1985) Structure and macromolecular organization of type VI collagen. Ann NY Acad Sci 460:25–37PubMedGoogle Scholar
  64. 64.
    Enzinger FM, Weiss SW (1995) Soft tissue tumors. 3rd ed. Mosby, St. Louis Baltimore Berlin Boston Carlsbad Chicago London Madrid Naples New York Philadelphia Sydney Tokyo TorontoGoogle Scholar
  65. 65.
    Epstein EH (1992) Molecular genetics of epidermolysis bullosa. Science 256:799–804PubMedGoogle Scholar
  66. 66.
    Erlacher L, Maier R, Ullrich R, Kiener H, Aringer M, Menschik M, Graninger W (1995) Differential expression of the protooncogen bcl-2 in normal and osteoarthritic human articular cartilage. J Rheumatol 22:926–931PubMedGoogle Scholar
  67. 67.
    Fleischmajer R, Perlish JS, Burgeson RE, Shaikh-Bahai F, Timpl R (1990) Type I and type III collagen interactions during fibrillogenesis. Ann NY Acad Sci 580:161–175PubMedGoogle Scholar
  68. 68.
    Galotto M, Campanile G, Robino G, Descalzi-Cancedda F, Bianco P, Cancedda R (1994) Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embryo. J Bone Mineral Res 9:1239–1249Google Scholar
  69. 69.
    Gentili C, Bianco P, Neri M et al. (1993) Cell proliferation, extracellular matrix mineralization, and ovotransferrin transient expression during in vitro differentiation of chick hypertrophic chondrocytes into osteoblast-like cells. J Cell Biol 122:703–712PubMedGoogle Scholar
  70. 70.
    Ghadially FN (1983) Fine structure of synovial joints. Butterworths, London Boston Durban Singapore Sydney Toronto WellingtonGoogle Scholar
  71. 71.
    Ghadially FN (1988) Preface to the first edition. In: Ultrastructural pathology of the cell and matrix. A text and atlas of physiological and pathological alterations in the fine structure of cellular and extracellular components, 3rd ed, in two volumes. Butterworths, London Boston Singapore Sydney Toronto Wellington, pp VII–IXGoogle Scholar
  72. 72.
    Ghadially FN, Lalonde J-MA, Wedge JH (1983) Ultrastructure of normal and torn menisci of the human knee joint. J Anat 136:773–791PubMedGoogle Scholar
  73. 73.
    Gibson GJ, Kohler WJ, Schaffler MB (1995) Chondrocyte apoptosis in endochondral ossification of chick sterna. Dev Dynamics 203:468–476Google Scholar
  74. 74.
    Gigante A, Carloni S, De Palma L (1997) Cells and extracellular matrix in Dupuytren’s diesease. J Bone Joint Surg [Br] (Suppl II) 79:161 (Abstr O 056)Google Scholar
  75. 75.
    Girkontaite I, Frischholz S, Lammi P, Wagner K, Swoboda B, Aigner T, von der Mark K (1996) Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies. Matrix Biol 15:231–238PubMedGoogle Scholar
  76. 76.
    Goldner J (1938) A modification of the Masson trichrome technique for routine laboratory purposes. Am J Pathol 14:237–242PubMedGoogle Scholar
  77. 11.
    Gömöri G (1937) Silver impregnation of reticulum in paraffin sections. Am J Pathol 13:993–1001PubMedGoogle Scholar
  78. 78.
    Gomori G (1950) Aldehyde-fuchsin: A new stain for elastic tissue. Am J Clin Pathol 20:665–666PubMedGoogle Scholar
  79. 79.
    Graabaek PM (1984) Characteristics of the two types of synoviocytes in rat synovial membrane. An ultrastructural study. Lab Invest 50:690–702PubMedGoogle Scholar
  80. 80.
    Graabaek PM (1985) Fine structure of the lysosomes in the two types of synoviocytes of normal rat synovial membrane. Cell Tissue Res 239:293–298PubMedGoogle Scholar
  81. 81.
    Grässel S, Chu M-L, Timpl R, Hawkins D, Dodge GR (1998) Type XVI collagen is expressed in human articular chondrocytes and cultured synovial cells. Arthritis Rheum (Suppl) 41:S191 (Abstr 952)Google Scholar
  82. 82.
    Gressner AM (1996) Mediators of hepatic fibrogenesis. Hepato-Gastroenterol 43:92–103Google Scholar
  83. 83.
    Gross J, Lapiere CM (1962) Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci 48:1014–1022PubMedGoogle Scholar
  84. 84.
    Gross J, Nagai Y (1965) Specific degradation of the collagen molecule by tadpole collagenolytic enzmye. Proc Natl Acad Sci 54:1197–1204PubMedGoogle Scholar
  85. 85.
    Hall CE, Jakus MA, Schmitt FO (1942) Electron microscope observations of collagen. J Am Chem Soc 64:1234Google Scholar
  86. 86.
    Hamilton JA, Campbell IK, Wojta J, Cheung D (1992) Plasminogen activators and their inhibitors in arthritic disease. Ann NY Acad Sci 667:87–100PubMedGoogle Scholar
  87. 87.
    Harris ED, DiBona DR, Krane SM (1970) Mechanisms of destruction of articular structures in rheumatoid arthritis. Excerpta Medica Int Congr Series 229:243–253Google Scholar
  88. 88.
    Harris M, Ahmed A (1977) The ultrastructure of tubular carcinoma of the breast. J Pathol 123:79–83PubMedGoogle Scholar
  89. 89.
    Hashimoto S, Setareh M, Ochs RL, Lotz M (1997) Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 40:1749–1755PubMedGoogle Scholar
  90. 90.
    Hass G, McDonald F (1940) Studies of collagen. I. The production of collagen in vitro under variable experimental conditions. Am J Pathol 16:525–548PubMedGoogle Scholar
  91. 91.
    Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG (1987) The collagen substrate specificity of human neutrophil collagenase. J Biol Chem 262:10048–10052PubMedGoogle Scholar
  92. 92.
    Hatori M, Klatte KJ, Teixeira CC, Shapiro IM (1995) End labeling studies of fragmented DNA in the avian growth plate: Evidence of apoptosis in terminally differentiated chondrocytes. J Bone Mineral Res 10:1960–1968Google Scholar
  93. 93.
    Haubeck H-D, Kock R, Fischer D-C, van de Leur E, Hoffmeister K, Greiling H (1995) Transforming growth factor βl, a major stimulator of hyaluronan synthesis in human synovial lining cells. Arthritis Rheum 38:669–677PubMedGoogle Scholar
  94. 94.
    Hayashi T, Abe E, Jasin HE (1996) Fibronectin synthesis in superficial and deep layers of normal articular cartilage. Arthritis Rheum 39:567–573PubMedGoogle Scholar
  95. 95.
    Hayashi T, Abe E, Yamate T, Taguchi Y, Jasin HE (1997) Nitric oxide production by superficial and deep articular chondrocytes. Arthritis Rheum 40:261–269PubMedGoogle Scholar
  96. 96.
    Heidenhain M (1916) Über die Mallorysche Bindegewebsfärbung mit Karmin und Azokarmin als Vorfarben. Z Wiss Mikrosk 32:361–372Google Scholar
  97. 97.
    Heinegård D, Oldberg Å (1989) Structure and biology of cartilage and bone matrix noncollagenous macromolecules. FASEB J 3:2042–2051PubMedGoogle Scholar
  98. 98.
    Hemler ME, Huang C, Schwarz L (1987) The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight β subunit. J Biol Chem 262:3300–3309PubMedGoogle Scholar
  99. 99.
    Hemmen B, Archer CW, Bentley G (1991) The effect of storage under low temperature tissue culture conditions of human articular cartilage. J Bone Joint Surg [Br] (Suppl 1) 73:58Google Scholar
  100. 100.
    Hewitt AT, Kleinman HK, Pennypacker JP, Martin GR (1980) Identification of an adhesion factor for chondrocytes. Proc Natl Acad Sci 77:385–388PubMedGoogle Scholar
  101. 101.
    Hogg N, Horton MA (1987) Myeloid antigens: new and previously defined clusters. In: McMichael AJ (ed) Leukocyte typing III. White cells differentiation antigens. Oxford University Press, Oxford New York Tokyo, pp 576–602Google Scholar
  102. 102.
    Holbrook KA, Byers PH (1982) Structural abnormalities in the dermal collagen and elastic matrix from the skin of patients with inherited connective tissue disorders. J Invest Dermatol (Suppl 1) 79:7s-16sGoogle Scholar
  103. 103.
    Hooghwinkel GJM, Smits G (1957) The specificity of the periodic acid-Schiff technique studied by a quantitative test-tube method. J Histochem Cytochem 5:122–126Google Scholar
  104. 104.
    Horton WA (1993) Morphology of connective tissue: Cartilage. In: Royce PM, Steinmann B (eds) Connective tissue and its heritable disorders. Molecular, genetic, and medical aspects. Wiley-Liss, New York Chichester Brisbane Toronto Singapore, pp 73–84Google Scholar
  105. 105.
    Hotchkiss RD (1948) A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. Arch Biochem 16:131–141PubMedGoogle Scholar
  106. 106.
    Hynes RO (1992) Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11–25PubMedGoogle Scholar
  107. 107.
    Ippolito E, Natali PG, Postacchini F, Accinni L, de Martino C (1980) Morphological, immunochemical, and biochemical study of rabbit Achilles tendon at various ages. J Bone Joint Surg [Am] 62:583–598Google Scholar
  108. 108.
    Irwin MH, Silvers SH, Mayne R (1985) Monoclonal antibody against chicken type IX collagen: Preparation, characterization, and recognition of the intact form of type IX collagen secreted by chondrocytes. J Cell Biol 101: 814–823PubMedGoogle Scholar
  109. 109.
    Iyama K-I, Ninomiya Y, Olsen BR, Linsenmayer TF, Trelstad RL, Hayashi M (1991) Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification. Anat Rec 229:462–472PubMedGoogle Scholar
  110. 110.
    Jacenko O, LuValle PA, Olsen BR (1993) Spondylometaphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition. Nature 365:56–61PubMedGoogle Scholar
  111. 111.
    Jacobs RL, Ray RD (1968) In-vitro binding of histologic stains by collagen. Clin Orthop 60:256–260PubMedGoogle Scholar
  112. 112.
    James WD, Odom RB (1980) The role of the myofibroblast in Dupuytren’s contracture. Arch Dermatol 116:807–811PubMedGoogle Scholar
  113. 113.
    Jander R, Korsching E, Rauterberg J (1990) Characteristics and in vivo occurrence of type VIII collagen. Eur J Biochem 189:601–607PubMedGoogle Scholar
  114. 114.
    Janoff A (1972) Human granulocyte elastase. Further delineation of its role in connective tissue damage. Am J Pathol 68:579–591PubMedGoogle Scholar
  115. 115.
    Janoff A, Scherer J (1968) Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 128:1137–1155PubMedGoogle Scholar
  116. 116.
    Jones CJP, Sear CHJ, Grant ME (1980) An ultrastructural study of fibroblasts derived from bovine ligamentum nuchae and their capacity for elastogenesis in culture. J Pathol 131:35–53PubMedGoogle Scholar
  117. 117.
    Kadler KE (1993) Learning how mutations in type I collagen genes cause connective tissue disease. Int J Exp Pathol 74:319–323PubMedGoogle Scholar
  118. 118.
    Kang AH, Nagai Y, Piez KA, Gross J (1966) Studies on the structure of collagen utilizing a collagenolytic enzyme from tadpole. Biochemistry 5:509–515PubMedGoogle Scholar
  119. 119.
    Keeley FW, Johnson DJ (1987) Age differences in the effect of hydrocortisone on the synthesis of insoluble elastin in aortic tissue of growing chicks. Connect Tissue Res 16:259–268PubMedGoogle Scholar
  120. 120.
    Keene DR, Maddox BK, Kuo H-J, Sakai LY, Glanville RW (1991) Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils. J Histochem Cytochem 39:441–449PubMedGoogle Scholar
  121. 121.
    Kielty CM, Hopkinson I, Grant ME (1993) Collagen: The collagen family: Structure, assembly, and organization in the extracellular matrix. In: Royce PM, Steinmann B (eds) Connective tissue and its heritable disorders. Molecular, genetic and medical aspects. Wiley-Liss, New York Chichester Brisbane Toronto Singapore, pp 103–147Google Scholar
  122. 122.
    Kirsch T, von der Mark K (1991) Isolation of human type X collagen and immunolocalization in fetal human cartilage. Eur J Biochem 196:575–580PubMedGoogle Scholar
  123. 123.
    Kivirikko KI (1993) Collagens and their abnormalities in a wide spectrum of diseases. Ann Med 25:113–126PubMedGoogle Scholar
  124. 124.
    Kleinman HK, Klebe JR, Martin GR (1981) Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol 88:473–485PubMedGoogle Scholar
  125. 125.
    Konieczny SF, Emerson CP (1984) 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: Evidence for regulatory genes controlling determination. Cell 38:791–800PubMedGoogle Scholar
  126. 126.
    Kölliker A (1861) Neue Untersuchungen über die Entwicklung des Bindegewebes. Verh Phys-Med Ges Würzburg. Würzburger Naturwiss Z 2:141–170Google Scholar
  127. 127.
    Kosher RA, Solursh M (1989) Widespread distribution of type II collagen during embryonic chick development. Dev Biol 131:558–566PubMedGoogle Scholar
  128. 128.
    Kostovi.-Kneževi L, Bradamante Ž, Švajger A (1981) Ultrastructure of elastic cartilage in the rat external ear. Cell Tissue Res 218:149–160Google Scholar
  129. 129.
    Kothary MH, Chase T, Macmillan JD (1984) Correlation of elastase production by some strains of Aspergillus fumigatus with ability to cause pulmonary invasive aspergillosis in mice. Infect Immun 43:320–325PubMedGoogle Scholar
  130. 130.
    Koukoulis GK, Gould VE, Bhattacharyya A, Gould JE, Howeedy AA, Virtanen I (1991) Tenascin in normal, reactive, hyperplastic, and neoplastic tissues: Biologic and pathologic implications. Hum Pathol 22:636–643PubMedGoogle Scholar
  131. 131.
    Kral W (1989) Untersuchungen zur Vitalität der Chondrozyten im menschlichen Leichenknorpel. Med Diss, Universität UlmGoogle Scholar
  132. 132.
    Krenkel S, Haensch R (1977) Elastic globes. Hautarzt 28:246–253PubMedGoogle Scholar
  133. 133.
    Kusuzaki K, Yamashita F, Sakakida K, Kamachi M, Ashihara T (1983) Feulgen-DNA cytofluorometry of the rat chondrocytes during growth and ageing. J Jpn Orthop Ass 57:721–727Google Scholar
  134. 134.
    Lawler J, Hynes RO (1987) Structural organization of the thrombospondin molecule. Semin Thromb Hemost 13:245–254PubMedGoogle Scholar
  135. 135.
    Lehtonen E, Stefanovic V, Saraga-Babic M (1995) Changes in the expression of intermediate filaments and desmoplakins during development of human notochord. Differentiation 59:43–49PubMedGoogle Scholar
  136. 136.
    Lefevre M, Rucker RB (1980) Aorta elastin turnover in normal and hypercholesterolemic Japanese quail. Biochim Biophys Acta 630:519–529PubMedGoogle Scholar
  137. 137.
    Lewinson D, Boskey AL (1984) Calmodulin localization in bone and cartilage. Cell Biol Int Rep 8:11–18PubMedGoogle Scholar
  138. 138.
    Libby WF, Berger R, Mead JF, Alexander GV, Ross JF (1964) Replacement rates for human tissue from atmospheric radiocarbon. Science 146:1170–1172PubMedGoogle Scholar
  139. 139.
    Linder E, Stenman S, Lehto V-P, Vaheri A (1978) Distribution of fibronectin in human tissues and relationship to other connective tissue components. Ann NY Acad Sci 312:151–159PubMedGoogle Scholar
  140. 140.
    Lindy O, Konttinen YT, Sorsa T, Ding Y, Santavirta S, Ceponis A, López-Otín C (1997) Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium. Arthritis Rheum 40:1391–1399PubMedGoogle Scholar
  141. 141.
    Lippiello L, Walsh T, Fienhold M (1991) The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage. Metabolism 40:571–576PubMedGoogle Scholar
  142. 142.
    Luse SA (1960) Electron microscopic studies of brain tumors. Neurology 10:881–905PubMedGoogle Scholar
  143. 143.
    Maier R, Ganu V, Lotz M (1993) Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J Biol Chem 268:21527–21532PubMedGoogle Scholar
  144. 144.
    Malejczyk J, Romaniuk A (1989) Reactivity of normal rat epiphyseal chondrocytes with monoclonal antibodies recognizing different leucocyte markers. Clin Exp Immunol 75:477–480PubMedGoogle Scholar
  145. 145.
    Malejczyk J, Malejczyk M, Urbanski A, Luger TA (1992) Production of natural killer cell activity-augmentation factor (interleukin-6) by human epiphyseal chondrocytes. Arthritis Rheum 35:706–713PubMedGoogle Scholar
  146. 146.
    Malemud CJ, Moskowitz RW, Hassid A (1981) Prostaglandin biosynthesis by lapine articular chondrocytes in culture. Biochim Biophys Acta 663:480–490PubMedGoogle Scholar
  147. 147.
    Mallory FB (1900) A contribution to staining methods. J Exp Med 5:15–20PubMedGoogle Scholar
  148. 148.
    Mandl I (1961) Collagenases and elastases. Adv Enzymol 23:163–264Google Scholar
  149. 149.
    Mandl I, MacLennan JD, Howes EL, DeBellis RH, Sohler A (1953) Isolation and characterization of proteinase and collagenase from Cl. histolyticum. J Clin Invest 32:1329Google Scholar
  150. 150.
    Mankin HJ (1978) The metabolism of articular cartilage. In: Simon WH (ed) The human joint in health and disease. University of Pennsylvania Press, Philadelphia, pp 53–70Google Scholar
  151. 151.
    Mapp PI, Revell PA (1988) Ultrastructural characterisation of macrophages (type A cells) in the synovial lining. Rheumatol Int 8:171–176PubMedGoogle Scholar
  152. 152.
    Maresch R (1905) Ueber Gitterfasern der Leber und die Verwendbarkeit der Methode Bielschofskys zur Darstellung feinster Bindegewebsfibrillen. Centralbl Allg Pathol Pathol Anat 16:641–649Google Scholar
  153. 153.
    Maroudas A (1975) Glycosaminoglycan turn-over in articular cartilage. Philos Trans R Soc Biol 271:293–313Google Scholar
  154. 154.
    Maroudas A (1980) Metabolism of cartilaginous tissues: a quantitative approach. In: Maroudas A, Holborow EJ (eds) Studies in joint diseases, vol 1. Pitman, Turnbridge Wells, England, pp 59–86Google Scholar
  155. 155.
    Martel-Pelletier J, McCollum R, DiBattista J et al. (1992) The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 35:530–540PubMedGoogle Scholar
  156. 156.
    Maschmann E (1938) Über Bakterienproteasen. IX. Mitteilung: Die Anaerobiase der Gasbranderreger. Biochem Z 297:284–296Google Scholar
  157. 157.
    Masson P (1929) Some histological methods. Trichrome stainings and their preliminary technique. J Technol Methods 12:75–90Google Scholar
  158. 158.
    Mathew J, Geerts A, Burt AD (1996) Pathobiology of hepatic stellate cells. Hepato-Gastroenterol 43:72–91Google Scholar
  159. 159.
    Matsubara T, Trüeb B, Fehr K, Rüttner JR, Odermatt BF (1984) The localization and secretion of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen. Exp Cell Biol 52:159–169PubMedGoogle Scholar
  160. 160.
    Matsushima K, Bano M, Kidwell WR, Oppenheim JJ (1985) Interleukin 1 increases collagen type IV production by murine mammary epithelial cells. J Immunol 134:904–909PubMedGoogle Scholar
  161. 161.
    Maximow A (1927-1928) Development of argyrophile and collagenous fibers in tissue cultures. Proc Soc Exp Biol Med 25:439–442Google Scholar
  162. 162.
    Maximow A (1928) Ueber die Entstehung von argyrophilen und kollagenen Fasern in Kulturen von Bindegewebe und von Blutleukozyten. Centralbl Allg Pathol Pathol Anat 43:145–152Google Scholar
  163. 163.
    Maximow A (1929) Über die Entwicklung argyrophiler und kollagener Fasern in Kulturen von erwachsenem Säugetiergewebe. Z Mikrosk Anat Forsch 17:625–659Google Scholar
  164. 164.
    McDevitt CA, Webber RJ (1990) The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop 252:8–18PubMedGoogle Scholar
  165. 165.
    McDonald MA, Chan ESL, Nesheim M, Anastassiades TP (1998) Proteoglycan release from articular cartilage by thrombin. J Rheumatol (Suppl 52) 25:26 (Abstr M95)Google Scholar
  166. 166.
    McElligott TF, Collins DH (1960) Chondrocyte function of human articular and costal cartilage compared by measuring the in vitro uptake of labelled (35S) sulphate. Ann Rheum Dis 19:31–40PubMedGoogle Scholar
  167. 167.
    McKusick VA (1972) Heritable disorders of connective tissue, 4th ed. Mosby, St. LouisGoogle Scholar
  168. 168.
    McManus JFA (1946) Histological demonstration of mucin after periodic acid. Nature 158:202PubMedGoogle Scholar
  169. 169.
    Mecham RP, Lange G, Madaras J, Starcher B (1981) Elastin synthesis by ligamentum nuchae fibroblasts: Effects of culture conditions and extracellular matrix on elastin production. J Cell Biol 90:332–338PubMedGoogle Scholar
  170. 170.
    Mecham RP, Madaras JG, Senior RM (1984) Extracellular matrix-specific induction of elastogenic differentiation and maintenance of phenotypic stability in bovine ligament fibroblasts. J Cell Biol 98:1804–1812PubMedGoogle Scholar
  171. 171.
    Meyer F (1997) Untersuchungen zur histochemischen Spezifität der Naphthol-AS-D-Chloracetat-Esterase-Reaktion. Med Diss, Universität UlmGoogle Scholar
  172. 172.
    Meyer K (1938) The chemistry and biology of mucopolysaccharides and glycoproteins. Cold Spring Harbor Symposia Quart Biol 6:91–101Google Scholar
  173. 173.
    Meyer K, Chaffee E (1941) The mucopolysaccharides of skin. J Biol Chem 137:491–499Google Scholar
  174. 174.
    Meyer K, Palmer JW (1934) The polysaccharide of the vitreous humor. J Biol Chem 107:629–634Google Scholar
  175. 175.
    Meyer K, Palmer JW (1936) On glyocproteins. II. The polysaccharides of vitreous humor and of umbilical cord. J Biol Chem 114:689–703Google Scholar
  176. 176.
    Meyer K, Rapport MM (1951) The mucopolysaccharides of the ground substance of connective tissue. Science 113:596–599PubMedGoogle Scholar
  177. 177.
    Miller RR, McDevitt CA (1988) The presence of thrombospondin in ligament, meniscus and intervertebral disc. Glycoconjugate J 5:312 (Abstr)Google Scholar
  178. 178.
    Miller RR, McDevitt CA (1988) Thrombospondin is present in articular cartilage and is synthesized by articular chondrocytes. Biochem Biophys Res Commun 153: 708–714PubMedGoogle Scholar
  179. 179.
    Mitchell D, Hardingham T (1981) The effects of cycloheximide on the biosynthesis and secretion of proteoglycans by chondrocytes in culture. Biochem J 196:521–529PubMedGoogle Scholar
  180. 180.
    Mohan PS, Carter WG, Spiro RG (1990) Occurrence of type VI collagen in extracellular matrix of renal glomeruli and its increase in diabetes. Diabetes 39:31–37PubMedGoogle Scholar
  181. 181.
    Mohr W (1987) Pathologie des Bandapparates. Sehnen, Sehnenscheiden, Faszien, Schleimbeutel. In: Doerr W, Scifert G (Hrsg) Spezielle pathologische Anatomie, Band 19. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  182. 182.
    Mohr W, Kirkpatrick CJ (1983) Die Relevanz von Tierversuchen für die menschliche Arthrose und die Beeinflussung der tierexperimentellen Arthrose durch Medikamente. Z Rheumatol 42:159–170PubMedGoogle Scholar
  183. 183.
    Mohr W, Bock G, Lossnitzer K (1976) Skeletal muscle regeneration in myopathic hamsters of strain BIO 8262. Virchows Arch B [Cell Pathol] 21:67–77Google Scholar
  184. 184.
    Moldovan F, Pelletier J-P, Hambor J, Cloutier J-M, Martel-Pelletier J (1997) Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ. In vitro mimicking effect by transforming growth factor ß. Arthritis Rheum 40: 1653–1661PubMedGoogle Scholar
  185. 185.
    Mollenhauer J, Bee JA, Lizarbe MA, von der Mark K (1984) Role of anchorin CII, a 31,000-mol-wt membrane protein, in the interaction of chondrocytes with type II collagen. J Cell Biol 98:1572–1578PubMedGoogle Scholar
  186. 186.
    Montagna W (1949) Glycogen and lipids in human cartilage, with some cytochemical observations on the cartilage of the dog, cat, and rabbit. Anat Rec 103:77–92PubMedGoogle Scholar
  187. 187.
    Moore RD, Schoenberg MD (1957) Studies on connective tissue. I. The polysaccharides of the human umbilical cord. A M A Arch Pathol 64:39–45Google Scholar
  188. 188.
    Moore RD, Schoenberg MD (1958) Studies on connective tissue. IV. The mast cell and its relation to the ground substance polysaccharides of the human umbilical cord. Lab Invest 7:418–425PubMedGoogle Scholar
  189. 189.
    Moran CA, Suster S, Abbondanzo SL (1997) Inflammatory pseudotumor of lymph nodes: A study of 25 cases with emphasis on morphological heterogeneity. Hum Pathol 28:332–338PubMedGoogle Scholar
  190. 190.
    Morgan MB, Pitha JV (1998) Myofibroblastoma of the breast revisited: An etiologic association with androgens? Hum Pathol 29:347–351PubMedGoogle Scholar
  191. 191.
    Mosesson MW, Amrani DL (1980) The structure and biologic activities of plasma fibronectin. Blood 56:145–158PubMedGoogle Scholar
  192. 192.
    Mosher DF (1984) Physiology of fibronectin. Annu Rev Med 35:561–575PubMedGoogle Scholar
  193. 193.
    Moskalewski S (1981) The elastogenetic process in transplants and cultures of isolated auricular chondrocytes. Connect Tissue Res 8:171–174PubMedGoogle Scholar
  194. 194.
    Moskalewski S, Osiecka A, Zieba P (1988) Binucleate chondrocytes in auricular cartilage of laboratory rodents. Folia Biol (Krakow) 36:265–268Google Scholar
  195. 195.
    Mowry RW (1956) Alcian blue technics for the histochemical study of acidic carbohydrates. J Histochem Cytochem 4:407Google Scholar
  196. 196.
    Mudgett JS, Hutchinson NI, Chartrain NA et al. (1998) Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum 41:110–121PubMedGoogle Scholar
  197. 197.
    Müller J (1836) Über die Structur und die chemischen Eigenschaften der thierischen Bestandteile der Knorpel und Knochen. Annalen der Physik und Chemie 38:295–353Google Scholar
  198. 198.
    Müller W (1861) Beiträge zur Kenntniss der Molekularstruktur thierischer Gewebe. Z Rationelle Med 10:173–194Google Scholar
  199. 199.
    Muragaki Y, Jacenko O, Apte S, Mattei M-G, Ninomiya Y, Olsen BR (1991) The α2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1. J Biol Chem 266:7721–7727PubMedGoogle Scholar
  200. 200.
    Murphy G, Docherty AJP (1992) The matrix metallopro-teinases and their inhibitors. Am J Respir Cell Mol Biol 7:120–125PubMedGoogle Scholar
  201. 201.
    Myers SL, Christine TA (1983) Hylauronate synthesis by synovial villi in organ culture. Arthritis Rheum 26:764–770PubMedGoogle Scholar
  202. 202.
    Nagase H, Barrett AJ, Woessner JF (1992) Nomenclature and glossary of the matrix metalloproteinases. MATRIX Suppl 1:421–424PubMedGoogle Scholar
  203. 203.
    Nageotte J (1931) Essais de reproduction in vitro de la trame collagène et hypothèses relatives a la construction de cette trame in vivo. Ann Anat Pathol Anat Normale Méd-Chir 8:1–11Google Scholar
  204. 204.
    Nakamura S, Nakamura T, Kawahara H (1988) S-100 protein in human articular cartilage. Acta Orthop Scand 59:438–440PubMedGoogle Scholar
  205. 205.
    Narayanan AS, Page RC (1985) Synthesis of type V collagen by fibroblasts derived from normal, inflamed and hyperplastic human connective tissues. Collagen Rel Res 5:297–304Google Scholar
  206. 206.
    Neuberger A, Slack HGB (1953) The metabolism of collagen from liver, bone, skin and tendon in the normal rat. Biochem J 53:47–52PubMedGoogle Scholar
  207. 207.
    Neuberger A, Perrone JC, Slack HGB (1951) The relative metabolic inertia of tendon collagen in the rat. Biochem J 49:199–204PubMedGoogle Scholar
  208. 208.
    Newsome DA, Linsenmayer TF, Trelstad RL (1976) Vitreous body collagen. Evidence for a dual origin from the neural retina and hyalocytes. J Cell Biol 71:59–67PubMedGoogle Scholar
  209. 209.
    Nishikawa S, Tamai M (1996) Ultrastructure of hyaluronic acid and collagen in the human vitreous. Curr Eye Res 15:37–43PubMedGoogle Scholar
  210. 210.
    Ollivierre F, Gubler U, Towle CA, Laurencin C, Treadwell BV (1986) Expression of IL-1 genes in human and bovine chondrocytes: A mechanism for autocrine control of cartilage matrix degradation. Biochem Biophys Res Commun 141:904–911PubMedGoogle Scholar
  211. 211.
    Padykula HA (1983) Umbilical cord. In: Weiss L (ed) Histology. Cell and tissue biology, 5th ed. MacMillan Press, London, pp 997–998Google Scholar
  212. 212.
    Palmiter RD, Davidson JM, Gagnon J, Rowe DW, Bornstein P (1979) NH2-terminal sequence of the chick proal(I) chain synthesized in the reticulocyte lysate system. J Biol Chem 254:1433–1436PubMedGoogle Scholar
  213. 213.
    Parry EW (1970) Some electron microscope observations on the mesenchymal structures of full-term umbilical cord. J Anat 107:505–518PubMedGoogle Scholar
  214. 214.
    Pinkus H, Mehregan AH, Staricco RG (1965) Elastic globes in human skin. J Invest Dermatol 45:81–84PubMedGoogle Scholar
  215. 215.
    Pras M, Glynn LE (1973) Isolation of a non-collagenous reticulin component and its primary characterization. Br J Exp Pathol 54:449–456PubMedGoogle Scholar
  216. 216.
    Pras M, Johnson GD, Holborow EJ, Glynn LE (1974) Antigenic properties of a non-collagenous reticulin component of normal connective tissue. Immunology 27:469–478PubMedGoogle Scholar
  217. 217.
    Prehm P (1984) Hyaluronate is synthesized at plasma membranes. Biochem J 220:597–600PubMedGoogle Scholar
  218. 218.
    Prockop DJ, Kivirikko KI, Tuderman L, Guzman NA (1979) The biosynthesis of collagen and its disorders. N Engl J Med 301:13–23PubMedGoogle Scholar
  219. 219.
    Pruzanski W, Bogoch E, Stefanski E, Wloch M, Vadas P (1990) Synthesis and release of phospholipase A2 by unstimulated human articular chondrocytes. J Rheumatol 17:1386–1391PubMedGoogle Scholar
  220. 220.
    Puchtler H, Sweat F (1964) Histochemical specifity of staining methods for connective tissue fibers: Resorcin-fuchsin and van Gieson’s picro-fuchsin. Histochemie 4:24–34Google Scholar
  221. 221.
    Puchtler H, Waldrop FS (1978) Silver impregnation methods for reticulum fibers and reticulin: A re-investigation of their origins and specifity. Histochemistry 57:177–187PubMedGoogle Scholar
  222. 222.
    Putschar W (1931) Über Fett im Knorpel unter normalen und pathologischen Verhältnissen. Beitr Pathol 87: 526–539Google Scholar
  223. 223.
    Raife TJ, Demetroulis EM, Lentz SR (1996) Regulation of thrombomodulin expression by all-trans retinoic acid and tumor necrosis factor-a: Differential responses in keratinocytes and endothelial cells. Blood 88:2043–2049PubMedGoogle Scholar
  224. 224.
    Reboul P, Pelletier J-P, Tardif G, Cloutier J-M, Martel-Pelletier J (1996) The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest 97:2011–2019PubMedGoogle Scholar
  225. 225.
    Recklies AD, Golds EE (1992) Induction of synthesis and release of interleukin-8 from human articular chondrocytes and cartilage expiants. Arthritis Rheum 35:1510–1519PubMedGoogle Scholar
  226. 226.
    Reddi AH (1994) Cartilage morphogenesis: Role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix. Matrix Biol 14:599–606Google Scholar
  227. 227.
    Regauer S, Sciler GR, Barrandon Y, Easley KW, Compton CC (1990) Epithelial origin of cutaneous anchoring fibrils. J Cell Biol 111:2109–2115PubMedGoogle Scholar
  228. 228.
    Rehn M, Pihlajaniemi T (1993) Mouse clones for type XIII collagen and one previously unidentified collagen chain. Matrix 13:12 (Abstr)Google Scholar
  229. 229.
    Reichenberger E, Aigner T, von der Mark K, Stöß H, Bertling W (1991) In situ hybridization studies on the expression of type X collagen in fetal human cartilage. Dev Biol 148:562–572PubMedGoogle Scholar
  230. 230.
    Reidy DP (1998) Oestrogen receptors in human articular cartilage chondrocytes in osteoarthritis. J Bone Joint Surg [Br] (Suppl 1) 80:62 (Abstr)Google Scholar
  231. 231.
    Richards AN, Gies WJ (1902) Chemical studies of elastin, mucoid, and other proteids in elastic tissue, with some notes on ligament extractives. Am J Physiol 7:93–134Google Scholar
  232. 232.
    Rippon JW, Varadi DP (1968) The elastases of pathogenic fungi and actinomycetes. J Invest Dermatol 50:54–58PubMedGoogle Scholar
  233. 233.
    Roach HI, Erenpreisa J, Aigner T (1995) Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J Cell Biol 131: 483–494PubMedGoogle Scholar
  234. 234.
    Roche WR (1990) Myofibroblasts. J Pathol 161:281–282PubMedGoogle Scholar
  235. 235.
    Romeis B (1968) Mikroskopische Technik. Oldenbourg Verlag, München WienGoogle Scholar
  236. 236.
    Rosenbloom J, Abrams WR, Mecham R (1993) Extracellular matrix 4: The elastic fiber. FASEB J 7:1208–1218PubMedGoogle Scholar
  237. 237.
    Rosner IA, Manni A, Malemud CJ, Boja B, Moskowitz RW (1982) Estradiol receptors in articular chondrocytes. Biochem Biophys Res Commun 106:1378–1382PubMedGoogle Scholar
  238. 238.
    Rötzer A (1991) Autoradiographische Untersuchungen zur Entstehung der Brutkapseln im Gelenkknorpel bei der Arthrose. Med Diss, Universität UlmGoogle Scholar
  239. 239.
    Roughley PJ, Lee ER (1994) Cartilage proteoglycans: Structure and potential functions. Microsc Res Tech 28:385–397PubMedGoogle Scholar
  240. 240.
    Rucklidge GJ, Milne G, Robins SP (1996) Collagen type-X: A component of the surface of normal human, pig, and rat articular cartilage. Biochem Biophys Res Commun 224:297–302PubMedGoogle Scholar
  241. 241.
    Ryan GB, Cliff WJ, Gabbiani G, Irlé C, Montandon D, Statkov PR, Majno G (1974) Myofibroblasts in human granulation tissue. Hum Pathol 5:55–67PubMedGoogle Scholar
  242. 242.
    Sahin AA, Ro JY, Ordonez NG, Luna MA, El-Naggar AK, Goepfert H, Ayala AG (1990) Myofibroblastoma of the tongue. An immunohistochemical, ultrastructural, and flow cytometric study. Am J Clin Pathol 94:773–777PubMedGoogle Scholar
  243. 243.
    Sakai LY, Keene DR (1994) Fibrillin: Monomers and microfibrils. In: Ruoslahti E, Engvall E (eds) Extracellular matrix components. Methods in Enzymology, vol 245. Academic Press, San Diego New York Boston London Sydney Tokyo Toronto, pp 29–52Google Scholar
  244. 244.
    Sakai LY, Keene DR, Engvall E (1986) Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol 103:2499–2509PubMedGoogle Scholar
  245. 245.
    Sakai LY, Keene DR, Glanville RW, Bächinger HP (1991) Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils. J Biol Chem 266:14763–14770PubMedGoogle Scholar
  246. 246.
    Sandberg LB, Soskel NT, Leslie JG (1981) Elastin structure, biosynthesis, and relation to disease states. N Engl J Med 304:566–579PubMedGoogle Scholar
  247. 247.
    Sanzone CF, Reith EJ (1976) The development of the elastic cartilage of the mouse pinna. Am J Anat 146:31–72PubMedGoogle Scholar
  248. 248.
    Schmid TM, Mayne R, Jeffrey JJ, Linsenmayer TF (1986) Type X collagen contains two cleavage sites for a vertebrate collagenase. J Biol Chem 261:4184–4189PubMedGoogle Scholar
  249. 249.
    Schmid TM, Popp RG, Linsenmayer TF (1990) Hypertrophic cartilage matrix. Type X collagen, supramolecular assembly, and calcification. Ann N Y Acad Sci 580:64–73PubMedGoogle Scholar
  250. 250.
    Schoenberg MD, Moore RD (1957) Studies on connective tissue. II. Histochemical differences in the connective tissue polysaccharides of the mature and immature human umbilical cord. A M A Arch Pathol 64:167–170Google Scholar
  251. 251.
    Schoenberg MD, Hinman A, Moore RD (1960) Studies on connective tissue. V. Fiber formation in Wharton’s jelly. Lab Invest 9:350–355PubMedGoogle Scholar
  252. 252.
    Schuppan D, Becker J, Boehm H, Hahn EG (1986) Immunofluorescent localization of type-V collagen as a fibrillar component of the interstitial connective tissue of human oral mucosa, artery and liver. Cell Tissue Res 243:535–543PubMedGoogle Scholar
  253. 253.
    Schwann T (1839) Mikroskopische Untersuchungen über die Uebereinstimmung in der Struktur und dem Wachsthum der Thiere und Pflanzen. Verlag der Sander’schen Buchhandlung (G. E. Reimer), BerlinGoogle Scholar
  254. 254.
    Schwartz E, Fleischmajer R (1986) Association of elastin with oxytalan fibers of the dermis and with extracellular microfibrils of cultured skin fibroblasts. J Histochem Cytochem 34:1063–1068PubMedGoogle Scholar
  255. 255.
    Scott DL, Salmon M, Walton KW (1984) Reticulin and its related structural connective tissue proteins in the rheumatoid synovium. Histopathology 8:469–479PubMedGoogle Scholar
  256. 256.
    Scott JE (1991) Proteoglycan: collagen interactions in connective tissues. Ultrastructural, biochemical, functional and evolutionary aspects. Int J Biol Macromol 13:157–161PubMedGoogle Scholar
  257. 257.
    Scott JE, Dorling J (1965) Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions. Histochemie 5:221–233PubMedGoogle Scholar
  258. 258.
    Seemayer TA, Lagacé R, Schürch W, Thelmo WL (1980) The myofibroblast: Biologic, pathologic, and theoretical considerations. Pathol Annu 15:443–470PubMedGoogle Scholar
  259. 259.
    Sheridan PJ, Aufdemorte TB, Holt GR, Gates GA (1985) Cartilage of the baboon contains estrogen receptors. Rheumatol Int 5:279–281PubMedGoogle Scholar
  260. 260.
    Singer NG, Todd RF, Fox DA (1994) Structures on the cell surface. Update from the fifth international workshop on human leukocyte differentiation antigens. Arthritis Rheum 37:1245–1248PubMedGoogle Scholar
  261. 261.
    Skalli O, Schürch W, Seemayer T, Lagacé R, Montandon D, Pittet B, Gabbiani G (1989) Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 60:275–285PubMedGoogle Scholar
  262. 262.
    Slack HGB (1954) Metabolism of elastin in the adult rat. Nature 174:512–513PubMedGoogle Scholar
  263. 263.
    Smith GN, Brandt KD (1992) Hypothesis: Can type IX collagen „glue“ together intersecting type II fibers in articular cartilage matrix?. A proposed mechanism. J Rheumatol 19:14–17PubMedGoogle Scholar
  264. 264.
    Ssadikow WS (1927) Über ein neues kollagen-lösendes Ferment [Kollagenase]. Biochem Z 181:267–283Google Scholar
  265. 265.
    Stark M, Kühn K (1968) The properties of molecular fragments obtained on treating calfskin collagen with collagenase from Clostridium histolyticum. Eur J Biochem 6:534–541PubMedGoogle Scholar
  266. 266.
    Steedman HF (1950) Alcian blue 8GS: A new stain for mucin. Q J Microscop Sci 91:477–479Google Scholar
  267. 267.
    Stefansson K, Wollmann RL, Moore BW, Arnason BGW (1982) S-100 protein in human chondrocytes. Nature 295:63–64PubMedGoogle Scholar
  268. 268.
    Stepp MA, Kindy M, Franzblau C, Sonenshein G (1985) Cloning of type III collagen and expression in aortic smooth muscle cells. Ann NY Acad Sci 460:510–513Google Scholar
  269. 269.
    Stetler-Stevenson WG, Krutzsch HC, Liotta LA (1989) Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J Biol Chem 264:17374–17378PubMedGoogle Scholar
  270. 270.
    Stockwell RA (1979) Biology of cartilage cells. Cambridge University Press, Cambridge London New York MelbourneGoogle Scholar
  271. 271.
    Summers KL, O’Donnell JL, Hoy MS, Peart M, Dekker J, Rothwell A, Hart DNJ (1995) Monocyte-macrophage antigen expression on chondrocytes. J Rheumatol 22: 1326–1334PubMedGoogle Scholar
  272. 272.
    Sun T, Susin M, Tomao FA, Brody J, Koduru P, Hajdu SI (1997) Histiocyte-rich B-cell lymphoma. Hum Pathol 28:1321–1324PubMedGoogle Scholar
  273. 273.
    Suzuki S, Oldberg Å, Hayman EG, Pierschbacher MD, Ruoslahti E (1985) Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin. EMBO J 4:2519–2524PubMedGoogle Scholar
  274. 274.
    Takechi K, Kuwabara Y, Mizuno M (1993) Ultrastructural and immunohistochemical studies of Wharton’s jelly umbilical cord cells. Placenta 14:235–245PubMedGoogle Scholar
  275. 275.
    Taylor DJ, Woolley DE (1987) Evidence for both histamine H1 and H2 receptors on human articular chondrocytes. Ann Rheum Dis 46:431–435PubMedGoogle Scholar
  276. 276.
    Taylor SM, Jones PA (1982) Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosinecontaining DNA. J Mol Biol 162:679–692PubMedGoogle Scholar
  277. 277.
    Thomas JT, Ayad S, Grant ME (1994) Cartilage collagens: strategies for the study of their organisation and expression in the extracellular matrix. Ann Rheum Dis 53:488–496PubMedGoogle Scholar
  278. 278.
    Tiku K, Thakker-Varia S, Ramachandrula A, Tiku ML (1992) Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity. Cell Immunol 140:1–20PubMedGoogle Scholar
  279. 279.
    Tiku ML, Liu S, Weaver CW, Teodorescu M, Skosey JL (1985) Class II histocompatibility antigen-mediated immunologic function of normal articular chondrocytes. J Immunol 135:2923–2928PubMedGoogle Scholar
  280. 280.
    Tiku ML, Liesch JB, Robertson FM (1990) Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines. J Immunol 145:690–696PubMedGoogle Scholar
  281. 281.
    Timpl R, Wiedemann H, van Delden V, Furthmayr H, Kühn K (1981) A network model for the organization of type IV collagen molecules in basement membranes. Eur J Biochem 120:203–211PubMedGoogle Scholar
  282. 282.
    Tomford WW, Fredericks GR, Mankin HJ (1984) Studies on cryopreservation of articular cartilage chondrocytes. J Bone Joint Surg [Am] 66:253–259Google Scholar
  283. 283.
    Toselli P, Salcedo LL, Oliver P, Franzblau C (1981) Formation of elastic fibers and elastin in rabbit aortic smooth muscle cell cultures. Connect Tissue Res 8:231–239PubMedGoogle Scholar
  284. 284.
    Unna PG (1890) Über die Taenzersche Färbung des elastischen Gewebes. Monatshefte Prakt Dermatol 11: 366–367Google Scholar
  285. 285.
    Unna PG (1891) Notiz, betreffend die Taenzersche Orceinfärbung des elastischen Gewebes. Monatshefte Prakt Dermatol 12:394–396Google Scholar
  286. 286.
    Unsworth DJ, Scott DL, Almond TJ, Beard HK, Holborow EJ, Walton KW (1982) Studies on reticulin. I.: Serological and immunohistological investigation of the occurrence of collagen type III, fibronectin and the non-collagenous glycoprotein of Pras and Glynn in reticulin. Br J Exp Pathol 63:154–166PubMedGoogle Scholar
  287. 287.
    Urist MR (1965) Bone: Formation by autoinduction. Science 150:893–899PubMedGoogle Scholar
  288. 288.
    Urist MR (1995) The first three decades of bone morphogenetic protein research. Osteologie 4:207–223Google Scholar
  289. 289.
    Urry DW, Luan C-H, Peng SQ (1995) Molecular biophysics of elastin structure, function and pathology. Ciba Foundation Symposion 192: The molecular biology and pathology of elastic tissues. Wiley and Sons, Chichester New York Brisbane Toronto Singapore, pp 4–22Google Scholar
  290. 290.
    van der Rest M (1982) Collagen structure and biosynthesis. In: Cruess RL (ed) The musculoskeletal system. Biology, biochemistry and physiology. Churchill Livingstone, New York Edinburgh London Melbourne, pp 59–79Google Scholar
  291. 291.
    van der Rest M, Garrone R (1991) Collagen family of proteins. FASEB J 5:2814–2823PubMedGoogle Scholar
  292. 292.
    van der Stricht O (1890) Recherches sur le cartilage articulaire des oiseaux. Arch Biol (Paris) 10:1–41Google Scholar
  293. 293.
    van Furth R (1981) The origin of phagocytic cells in the joint and bone. Scand J Rheumatol (Suppl) 40:13–20Google Scholar
  294. 294.
    van Gieson I (1889) Laboratory notes of technical methods for the nervous system. NY Med J 50:57–60Google Scholar
  295. 295.
    Vasudev KS, Harris M (1978) A sarcoma of myofibroblasts. An ultrastructural study. Arch Pathol Lab Med 102:185–188PubMedGoogle Scholar
  296. 296.
    Verschure PJ, van Marie J, Joosten LAB, van den Berg WB (1995) Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis. Ann Rheum Dis 54:645–653PubMedGoogle Scholar
  297. 297.
    Villiger PM, Lotz M (1992) Differential expression of TGFβ isoforms by human articular chondrocytes in response to growth factors. J Cell Physiol 151:318–325PubMedGoogle Scholar
  298. 298.
    von der Mark K, Goodman S (1993) Adhesive glycoproteins. In: Royce PM, Steinmann B (eds) Connective tissue and its heritable disorders. Molecular, genetic and medical aspects. Wiley-Liss, New York Chichester Brisbane Toronto Singapore, pp 211–236Google Scholar
  299. 299.
    von der Mark K, von der Mark H, Timpl R, Trelstad RL (1977) Immunofluorescent localization of collagen types I, II, and III in the embryonic chick eye. Dev Biol 59:75–85PubMedGoogle Scholar
  300. 300.
    Vyalov S, Desmoulière A, Gabbiani G (1993) GM-CSF-in-duced granulation tissue formation: relationships between macrophage and myofibroblast accumulation. Virchows Arch B Cell Pathol 63:231–239Google Scholar
  301. 301.
    Waldeyer A, Mayet A (1980) Anatomie des Menschen, Teil 1, 14. Aufl. De Gruyter, Berlin New YorkGoogle Scholar
  302. 302.
    Wang N-S, Minassian H (1987) The formaldehyde-fixed and paraffin-embedded tissues for diagnostic transmission electron microscopy: A retrospective and prospective study. Hum Pathol 18:715–727PubMedGoogle Scholar
  303. 303.
    Watt SL, Lunstrum GP, McDonough AM, Keene DR, Burgeson RE, Morris NP (1992) Characterization of collagen types XII and XIV from fetal bovine cartilage. J Biol Chem 267:20093–20099PubMedGoogle Scholar
  304. 304.
    Webber RJ (1990) In vitro culture of meniscal tissue. Clin Orthop 252:114–120PubMedGoogle Scholar
  305. 305.
    Webber RJ, Harris MG, Hough AJ (1985) Cell culture of rabbit meniscal fibrochondrocytes: Proliferative and synthetic response to growth factors and ascorbate. J Orthop Res 3:36–42PubMedGoogle Scholar
  306. 306.
    Weigert C (1898) Ueber eine Methode zur Färbung elastischer Fasern. Zentralbl Allg Pathol 9:289–292Google Scholar
  307. 307.
    Welgus HG, Jeffrey JJ, Eisen AZ (1981) The collagen substrate specificity of human skin fibroblast collagenase. J Biol Chem 256:9511–9515PubMedGoogle Scholar
  308. 308.
    Werb Z, Banda MJ, McKerrow JH, Sandhaus RA (1982) Elastases and elastin degradation. J Invest Dermatol (Suppl 1) 79:154s-159sGoogle Scholar
  309. 309.
    Wilkinson LS, Pitsillides AA, Worrall JG, Edwards JCW (1992) Light microscopic characterization of the fibroblast-like synovial intimai cell (synoviocyte). Arthritis Rheum 35:1179–1184PubMedGoogle Scholar
  310. 310.
    Wolman M, Kasten FH (1986) Polarized light microscopy in the study of the molecular structure of collagen and reticulin. Histochemistry 85:41–49PubMedGoogle Scholar
  311. 311.
    Wolpers C (1943) Kollagenquerstreifung und Grundsubstanz. Klin Wochenschr 22:624Google Scholar
  312. 312.
    Woods VL, Schreck PJ, Gesink DS, Pacheco HO, Amiel D, Akeson WH, Lotz M (1994) Integrin expression by human articular chondrocytes. Arthritis Rheum 37:537–544PubMedGoogle Scholar
  313. 313.
    Yoshioka C, Yagi T (1988) Electron microscopic observations on the fate of hypertrophic chondrocytes in condylar cartilage of rat mandible. J Craniofac Genet Dev Biol 8:253–264PubMedGoogle Scholar
  314. 314.
    Young HE, Ceballos EM, Smith JC et al. (1993) Pluripotent mesenchymal stem cells reside within avian connective tissue matrices. In Vitro Cell Dev Biol 29 A:723–736Google Scholar
  315. 315.
    Young PCM, Stack MT (1982) Estrogen and glucocorticoid receptors in adult canine cartilage. Arthritis Rheum 25:568–573PubMedGoogle Scholar
  316. 316.
    Zetkin M, Kühtz E-H, Fichtel K (1964) Wörterbuch der Medizin. VEB Verlag Volk und Gesundheit, BerlinGoogle Scholar
  317. 317.
    Zohar R, Sodek J, McCulloch CAG (1997) Characterization of stromal progenitor cells enriched by flow cytometry. Blood 90:3471–3481PubMedGoogle Scholar
  318. 318.
    Zollikofer H (1852) Beiträge zur Kenntniss des elastischen Gewebes. Justus Liebigs Ann Chem 82:162–180Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Winfried Mohr
    • 1
  1. 1.Universität Ulm Abt. PathologieUlmGermany

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