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Receptor Modulators of B-Cell Receptor Signalling — CD19/CD22

  • Chapter
Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 245/1))

Abstract

Activation of the B cell by stimulation through its antigen receptor, along with cooperation from a cognate T cell, forms the basis of the T-cell-dependent humoral immune response. The amount of information that can be transmitted to the B cell by this simple interaction with membrane immunoglobulin (mIg) is, however, limited. Optimally, B-cell responses should be maximised if the B cell is in an appropriate microenvironment, if the antigen is likely to be dangerous to the host, and if an adequate immune response to the antigen has not already been made. There is increasing evidence that activation through the B-cell receptor (BCR) can be modulated by a number of co-receptors, providing the B cell with information of this kind. Two of these co-receptors, CD22 and CD19, will be discussed in this review.

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Authors and Affiliations

  1. The Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, CB2 2SP, England

    K. G. C. Smith & D. T. Fearon

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  1. K. G. C. Smith
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  2. D. T. Fearon
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Editors and Affiliations

  1. Division of Developmental & Clinical Immunology Department of Microbiology, University of Alabama at Birmingham, 378 Wallace Tumor Institute, Birmingham, AL, 35492-3300, USA

    Louis B. Justement Ph.D. (Associate Professor) (Associate Professor)

  2. Department of Medicine, University of Toronto Mount Sinai Hospital, 600 University Ave., Rm. 656A, M5G IX5, Toronto, Ontario, Canada

    Katherine A. Siminovitch M.D.

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Smith, K.G.C., Fearon, D.T. (2000). Receptor Modulators of B-Cell Receptor Signalling — CD19/CD22. In: Justement, L.B., Siminovitch, K.A. (eds) Signal Transduction and the Coordination of B Lymphocyte Development and Function I. Current Topics in Microbiology and Immunology, vol 245/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57066-7_6

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  • DOI: https://doi.org/10.1007/978-3-642-57066-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63017-0

  • Online ISBN: 978-3-642-57066-7

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