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Pathologie der Leber und Gallenwege pp 612–699Cite as

Toxische Hepatosen

Medikamentöse und gewerbetoxische Leberschäden

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Part of the book series: Spezielle pathologische Anatomie ((SPEZIELLE,volume 10))

Zusammenfassung

Umweltstoffe, gewerbliche Toxine, häusliche und pflanzliche Gifte und schließlich Medikamente bergen Risiken seit alters, und in neuerer Zeit gesellen sich Verunreinigungen von Luft, Wasser und Nahrung hinzu. Die meisten dieser Stoffe und Medikamente insbesondere, treffen vornehmlich und zuerst die Leber als das wesentliche Stoffwechselorgan. Um immer möglichen Schädigungen zu begegnen, hat man sich gewöhnt, jedenfalls die industriellen und pharmakologisch definierten Substanzen auf ihre Toxizität zu überprüfen, im Tierversuch zu testen und — nach ihrer Freigabe — auf unerwartete Wirkungen und Nebenwirkungen besonders zu achten. Trotz alledem sind wir häufig nicht in der Lage, selbst schwere Leberschäden innerhalb einzelner Subpopulationen vorauszusagen, sie, wo sie einmal auftreten, hinreichend rasch zu entdecken und — nach einem Zwischenfall — jeweils einvernehmlich zu klären, was genau sich ereignet, welche abnorme Reaktion stattgefunden hat. Zweifellos wird sich daran auch zukünftig nichts Entscheidendes ändern können; dies umso weniger angesichts einer offenbar zunehmenden Neigung zu Selbstbehandlung, womöglich mit undeklarierten pflanzlichen Zubereitungen (Georgii et al. 1988; Perharic Walton u. Murray 1992; Kane et al. 1995; Larrey u. Pageaux 1995), wodurch es im Ernstfall vollends ausgeschlossen ist, brauchbare Übersicht zu gewinnen.

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Klinge, O. (2000). Toxische Hepatosen. In: Pathologie der Leber und Gallenwege. Spezielle pathologische Anatomie, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57036-0_9

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