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Port-Site and Wound Recurrences in Cancer Surgery pp 69–73Cite as

Pathogenesis: Free Viable Cancer Cells and Cancer Cell Liberation in Clinical Studies

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Abstract

The traditional pathways of tumor cell transportation involve blood vessels and lymphatic vessels causing hematogenous and lymphatogenous metastases, respectively. Since close lymphatic connections between the abdominal viscera and the abdominal wall are scarce, it appears unlikely that port-site recurrences are due to lymphatic spread of cells originating from visceral cancers. However, hematogenous dissemination of cancer cells to sites of active cellular proliferation seems more prevalent. Cancer cells were detected, employing monoclonal antibodies for tumor-associated antigens (Juhl et al. 1994; Lindemann et al. 1992) in bone marrow of up to 40% of patients with digestive cancers. Murthy et al. (1989) demonstrated that tumor cells injected intravenously can cause tumor formation at the site of the laparotomy. Fresh wounds provide blood clots with a variety of tissue-specific growth factors creating a favorable environment for tumor cell growth (Murthy et al. 1989; Gutmann et al.1995).

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References

  • Alexander R.J.T., Jaques B.C., Mitchell K.G. (1993) Laparoscopically assisted colectomy and wound recurrence. Lancet 341: 249–250

    Article  PubMed  CAS  Google Scholar 

  • Ambrose N.S., MacDonald F., Young J., Thompson H., Keighley M.R. (1989) Monoclonal antibody and cytological detection of free malignant cells in the peritoneal cavity during resection of colorectal cancer-can monoclonal antibodies do better? Eur J Surg Oncol 15: 99–102

    PubMed  CAS  Google Scholar 

  • Buchmann P., Christen D., Buschta G., Sartoretti Ch. (1997) Intraperitoneal tumor cell spread during colorectal cancer surgery: follow up of the comparison of laparoscopic versus open surgery. Langenbecks Arch Chir Suppl Kongressbd 114: 1122–1124

    PubMed  CAS  Google Scholar 

  • Buchmann P., Christen D., Buschta G. (1999a) Intraperitoneal tumor spread during surgery for colorectal cancer (submitted)

    Google Scholar 

  • Buchmann P., Buschta G., Christen D. (1999b) Intraperitoneal free tumor cells in colorectal cancer. Surgery-port-site recurrences and outcome. Langenbeck Arch Chir (in press)

    Google Scholar 

  • Cook T.A., Dehn T.C.B. (1996) Port-site recurrences in patients undergoing laparoscopy for gastrointestinal malignancy. Br J Surg 83: 1419–1420

    Article  PubMed  CAS  Google Scholar 

  • Drouard F., Delamarre I., Capron J.P. (1991) Cutaneous seeding of gallbladder cancer after laparoscopic cholecystectomy. N Engl J Med 325: 1316

    PubMed  CAS  Google Scholar 

  • Fermor B., Umpleby H.C., Lever J.V., Symes M.O., Williamson R.C.N. (1986) Proliferative and metastatic potential of exfoliated colorectal cancer cells. J Natl Cancer Inst 76: 347–349

    PubMed  CAS  Google Scholar 

  • Fusco M.A., Paluzzi M.W. (1993) Abdominal wall recurrence after laparoscopic-assisted colectomy for adenocarinoma of the colon. Report of a case. Dis Colon Rectum 36: 858–861

    Article  PubMed  CAS  Google Scholar 

  • Gertsch P., Baer H.U., Kraft R., Maddern G.J., Altermatt H.J. (1992) Malignant cells are collected on circular staplers. Dis Colon Rectum 35: 238–241

    Article  PubMed  CAS  Google Scholar 

  • Gutman M., Fidler I.J. (1995) Biology of human colon cancer metastasis. World J Surg 19: 226–234

    Article  PubMed  CAS  Google Scholar 

  • Hase K., Ueno H., Kuranaga N., Utsunomiya K., Kanabe S., Mochizuki W. (1998) Intraperitoneal exfoliated cancer cells in patients with colorectal cancer. Dis Colon Rectum 41: 1134–1140

    Article  PubMed  CAS  Google Scholar 

  • Horattas M.C., Evasovich M.R., Topham N. (1997) Colorectal carcinoma and the relationship of peritoneal cytology. Am J Surg 174: 334–337

    Article  PubMed  CAS  Google Scholar 

  • Johnstone P.A., Rohde D.C., Swartz S.E., Fetter J.E., Wexner S.D. (1996) Port-site recurrences after laparoscopic and thoracoscopic procedures in malignancy. J Clin Oncol 14: 1950–1956

    PubMed  CAS  Google Scholar 

  • Juhl H., Stritzel M., Wroblewski A., Henne-Bruns D., Kremer B., Schmiegel W., Neumaier M, Wagener C., Schreiber H.W., Kalthoff H. (1994) Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients. Int J Cancer 57: 330–335

    Article  PubMed  CAS  Google Scholar 

  • Kim S.H., Milsom J.W., Gramlich T.L., Toddy S.M., Shore G.I., Okuda J., Fazio V.W. (1998) Does laparoscopic vs. conventional surgery increase exfoliated cancer cells in the peritoneal cavity during resection of colorectal cancer? Dis Colon Rectum 41: 971–978

    Article  PubMed  CAS  Google Scholar 

  • Leather A.J., Kocjan G., Savage F., Hu W., Yiu C.Y., Boulos P.B., Northover J.M., Philips R.K. (1994) Detection of free malignant cells in the peritoneal cavity before and after resection of colorectal cancer. Dis Colon Rectum 37: 814–819

    Article  PubMed  CAS  Google Scholar 

  • Lindemann F., Schlimok G., Dirschedl P., Witte I., Riethmuller G. (1992) Prognostic significance of micro metastatic tumor cells in bone marrow of colorectal cancer patients. Lancet 340:685–689

    Article  PubMed  CAS  Google Scholar 

  • Martin J.K. Jr., Goellner J.R. (1986) Abdominal fluid cytology in patients with gastrointestinal malignant lesions. Mayo Clin Proc 61: 467–471

    Article  PubMed  Google Scholar 

  • Murphy P.D., Wadhera V., Griffin S.M., Burgess P., Farrell D., Tylor I., Hair T., Clague M.B., Griffith C.D. (1993) Free peritoneal tumor cell identification in patients with gastric and colorectal cancer. J R Coll Surg Edinb 38: 28–32

    PubMed  CAS  Google Scholar 

  • Murthy S.M., Goldschmidt R.A., Rao L.N., Ammirati M., Buchmann T., Scanlon E.F. (1989) The influence of surgical trauma on experimental metastasis. Cancer 64: 2035–2044

    Article  PubMed  CAS  Google Scholar 

  • Nieveen van Dijkum E.J., de Wit L.T., Oberdorp H., Gouma.D.J (1996) Port-site recurrences following diagnostic laparoscopy. Br J Surg 83: 1793–1794

    Article  Google Scholar 

  • Schaeff B., Paolucci V., Henze A. (1999) Electron microscopic study on mesothelial cells after laparoscopic operations. Surg Endosc 13: S 24

    Google Scholar 

  • Schott A., Vogel I., Krueger U., Kalthoff H., Schreiber H.W., Schmiegel W., Henne-Bruns D., Kremer B., Juhl H. (1998) Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker. Ann Surg 227: 372–379

    Article  PubMed  CAS  Google Scholar 

  • Skipper D., Cooper A.J., Marston J.E., Taylor I. (1987) Exfoliate d cells and in vitro growth in colorectal cancer. Br J Surg 74: 1049–1052

    Article  PubMed  CAS  Google Scholar 

  • Slanetz C.A. Jr. (1998) Effect of no touch isolation on survival and recurrence in curative resections for colorectal cancer. Ann Surg Oncol 5: 390–398

    Article  PubMed  Google Scholar 

  • Stockdale A.D., Pocock T.J. (1985) Abdominal wall metastasis following laparoscopy: a case report. Eur J Surg Oncol 11: 373–375

    PubMed  CAS  Google Scholar 

  • Texler M.L., King G., Hewett P.J. (1998) From inside out. Microperforation of the gallbladder during laparoscopic surgery may liberate mucosal cells. Surg Endosc 12: 1297–1299

    Article  PubMed  CAS  Google Scholar 

  • Uras C., Altinkaya E., Yardimci H., Goksel S., Yavuz N., Kaptanoglu L., Akcal T. (1996) Peritoneal cytology in the determination of free tumor cells within the abdomen in colon cancer. Surg Oncol 5: 259–263

    Article  PubMed  CAS  Google Scholar 

  • Ugarte F. (1995) Laparoscopic cholecystectomy port seeding from a colon carcinoma. Am Surg 61: 820–821

    PubMed  CAS  Google Scholar 

  • Walsh D.C.A., Wattchow D.A., Wilson T.G. (1993) Subcutaneous metastases after laparoscopic resection of malignancy. Aust N Z J Surg 63: 5635

    Article  Google Scholar 

  • Wiggers T., Jeekel J., Arends J.W., Brinkhorst A.P., Kluck H.M., Luyk C.I., Munting C.D., Povel J.A., Rfutten A.P., Volovics A. (1988) Notouch isolation technique in colon cancer: a controlled prospective trial. Br J Surg 75: 409–415

    Article  PubMed  CAS  Google Scholar 

  • Wong L.S., Bateman W.J., Morris A.G., Fraser I.A. (1995) Detection of circulating tumor cells with the magnetic activated cell sorter. Br J Surg 82: 1333–1337

    Article  PubMed  CAS  Google Scholar 

  • Wong L.S., Morris A.G., Fraser I.A. (1996) The exfoliation of free malignant cells in the peritoneal cavity during resection of colorectal cancer. Surg Oncol 5: 115–121

    Article  PubMed  CAS  Google Scholar 

  • Yamashita K., Kuba T., Shinoda H., Takahashi E., Okayasu I. (1998) Detection of K-ras point mutations to cytologic examination. Am J Clin Pathol 109: 704–711

    PubMed  CAS  Google Scholar 

  • Zuna R.E., Mitchell M.L. (1988) Cytologic findings in peritoneal washings associated with benign gynecologic disease. Acta Cytol 32: 139–147

    PubMed  CAS  Google Scholar 

  • Zuna R.E., Mitchell M.L., Muliack K.A., Weijchert W.M. (1989) Cytohistologic correlation of peritoneal washing cytology in gynecologic disease. Acta Cytol 33: 327–336

    PubMed  CAS  Google Scholar 

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Authors
  1. P. Buchmann
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  2. D. Christen
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  3. L. Stocchi
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  4. H. Nelson
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Editor information

Editors and Affiliations

  1. Department of Surgery, University Hospital of Magdeburg, Leipziger Strasse 44, Magdeburg, 39120, Germany

    Marc A. Reymond M.D. (Associate Professor of Surgery) (Associate Professor of Surgery)

  2. University Hospital Rotterdam Dijkzigt Hospital, Rotterdam, 3000 CA, PO Box 2040, The Netherlands

    H. Jaap Bonjer M.D., Ph.D. (Head of Laparoscopic Surgery and Acting Head of Endocrine Surgery) (Head of Laparoscopic Surgery and Acting Head of Endocrine Surgery)

  3. Hanover Hospital, Roesebeckstrasse 15 Siloah, Hannover, 30449, Germany

    Ferdinand Köckerling M.D. (Professor of Surgery and Head Department of Surgery and Center for Minimally Invasive Surgery) (Professor of Surgery and Head Department of Surgery and Center for Minimally Invasive Surgery)

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© 2000 Springer-Verlag Berlin Heidelberg

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Buchmann, P., Christen, D., Stocchi, L., Nelson, H. (2000). Pathogenesis: Free Viable Cancer Cells and Cancer Cell Liberation in Clinical Studies. In: Reymond, M.A., Bonjer, H.J., Köckerling, F. (eds) Port-Site and Wound Recurrences in Cancer Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57028-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-57028-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63117-7

  • Online ISBN: 978-3-642-57028-5

  • eBook Packages: Springer Book Archive

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