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Reference Materials in Clinical and Forensic Toxicological Analysis

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Reference Materials in Analytical Chemistry

Part of the book series: Springer Series in Materials Science ((SSMATERIALS,volume 40))

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Abstract

In clinical as well as forensic toxicology a wide variety of illicit and therapeutic drugs, pesticides or chemicals used in daily life and their metabolites are to be identified and quantitatively determined in human blood, urine or tissues. Preferred methods are immunoassays and chromatographic methods combined with UV or mass spectrometry. Reference materials in this field are equally important for a correct qualitative and quantitative analysis and are available as pure compounds, solutions in water or other solvents, and in serum or urine in liquid or lyophilized state. In forensic investigation of offences under influence of alcohol, standard solutions of ethanol and congener alcohols in water, serum or whole blood are used for calibration and as controls, as well as reference sera for measurement of clinical parameters characterizing chronic alcohol abuse. Reference materials in urine used for calibration and control of immunoassays in detection of illicit and therapeutic drug abuse contain in most cases only one drug, which is representative for a whole substance group with similar structure and effect. Therefore these methods are primarily destined for qualitative assays. Deuterated standards of many drugs have been established as advantageous internal standards for quantitative determination of very low concentrations in human material by gas chromatography/mass spectrometry.

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Authors
  1. Fritz Pragst
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  2. Wolf-Rüdiger Külpmann
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Editor information

Editors and Affiliations

  1. Bundesanstalt für Metallforschung und -prüfung, Richard-Willstätter-Strasse 11, 12489, Berlin, Germany

    Adolf Zschunke

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© 2000 Springer-Verlag Berlin Heidelberg

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Pragst, F., Külpmann, WR. (2000). Reference Materials in Clinical and Forensic Toxicological Analysis. In: Zschunke, A. (eds) Reference Materials in Analytical Chemistry. Springer Series in Materials Science, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56986-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-56986-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63097-2

  • Online ISBN: 978-3-642-56986-9

  • eBook Packages: Springer Book Archive

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