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Genes Involved in Resistance to Carcinogenesis

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Genes and Resistance to Disease

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Abstract

The pathogenesis of human disease is influenced by many interacting factors and is determined by the balance between the environment in which we live and genetic susceptibility (Doll and Peto 1981). This is exemplified by the variations in disease incidence in different parts of the world. For example, migration studies show that, whereas breast cancer incidence in Japan is low, in Japanese women living in the USA it is similar to that of the rest of the US population. This demonstrates that environmental factors are the principal determinants of disease incidence (Potter 1997). However, within any population the observation that certain individuals are more susceptible than others to a particular disease indicates that genetic factors are important.

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Authors
  1. C. R. Wolf
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Editor information

Editors and Affiliations

  1. Human Genetics Department of Noncommunicable Disease Prevention, World Health Organization, 1211 Geneva 27, Switzerland

    V. Boulyjenkov

  2. Institute of Medical Genetics, University of Oslo, Oslo, Norway

    K. Berg

  3. Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    K. Berg

  4. Fondation IPSEN, Pour la Recherche Thérapeutique, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Y. Christen Ph. D.

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© 2000 Springer-Verlag Berlin Heidelberg

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Wolf, C.R. (2000). Genes Involved in Resistance to Carcinogenesis. In: Boulyjenkov, V., Berg, K., Christen, Y. (eds) Genes and Resistance to Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56947-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-56947-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63086-6

  • Online ISBN: 978-3-642-56947-0

  • eBook Packages: Springer Book Archive

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