Abstract
As in other tissues, it is now well established that nucleotides are released into the extracellular fluid of the respiratory tract during normal homeostatic as well as pathologic conditions to act on cell surface P2 purinergic receptors. Both the ligand gated ion channel P2X subtype and the G-protein coupled P2Y subtype have been identified and shown to provide important regulatory functions in essentially all cell components of the respiratory system. Taken together these functions appear to enhance respiratory host defense by accelerating mucociliary clearance, facilitating inflammation and possibly aiding tissue repair. The evidence that supports each of these functions is reviewed below.
Keywords
- Cystic Fibrosis
- P2Y2 Receptor
- Mucociliary Clearance
- Cystic Fibrosis Transmembrane Regulator
- Ciliary Beat Frequency
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Wegner, C.D. (2001). P2 Receptors in the Respiratory System. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_8
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