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P1 and P2 Receptors in the Renal System

  • Chapter
Purinergic and Pyrimidinergic Signalling II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 151 / 2))

Abstract

Modulation of the function of excretory organs by purine receptors is an ancient regulatory strategy adopted early in the course of vertebrate evolution. For instance, in the shark rectal gland, an excretory organ that evolved more than 400 million years ago, primordial adenosine receptors strongly influence the rate of sodium chloride transport and elimination (Forrest 1996). It is not surprising therefore that P1 and P2 receptors are important regulators of renal function in mammals. The purpose of this chapter is to summarize the available information regarding the physiology and pharmacology of renal P1 and P2 receptors and to discuss where this field will likely yield important advances in pharmacotherapeutics.

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  1. Center for Clinical Pharmacology, University of Pittsburgh Medical Center, 623 Scaife Hall, 200 Lothrop Street, Pittsburgh, PA, 15213-2582, USA

    E.K. Jackson

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  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215) 303 East Chicago Avenue, Chicago, IL, 60611

    Michael Williams

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Jackson, E. (2001). P1 and P2 Receptors in the Renal System. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_2

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