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Purinergic and Pyrimidinergic Receptor Signaling in Bone Cells

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Purinergic and Pyrimidinergic Signalling II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 151 / 2))

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Abstract

Bone-forming osteoblasts and bone-resorbing osteoclasts work together to remodel bone. During its lifetime each cell type expresses a variety of signaling receptors, including those for parathyroid hormone (PTH), calcitonin, various cytokines, steroids, prostaglandins, and nucleotides. These receptors and their linked intracellular signaling pathways regulate proliferation, differentiation, and bone remodeling activity. There are extracellular signaling molecules that convey information between osteoblasts and osteoclasts; one is known (interleukin-6), but the identities of others are unknown.

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Authors and Affiliations

  1. Medical Research Council Group in Periodontal Physiology, University of Toronto, Toronto, M5S 3E2, Canada

    J. Ferrier

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  1. J. Ferrier
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215) 303 East Chicago Avenue, Chicago, IL, 60611

    Michael Williams

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© 2001 Springer Berlin Heidelberg

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Ferrier, J. (2001). Purinergic and Pyrimidinergic Receptor Signaling in Bone Cells. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-56921-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67848-9

  • Online ISBN: 978-3-642-56921-0

  • eBook Packages: Springer Book Archive

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