Purinergic Receptors and the Pharmacology of Type 2 Diabetes

  • P. Petit
  • D. Hillaire-Buys
  • M.M. Loubatières-Mariani
  • J. Chapal
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 151 / 2)


Diabetes mellitus is the phenotypic expression of a disorder resulting from various environmental factors interacting with a genetic component. It is an heterogeneous metabolic syndrome consisting of a dysregulation of glucose homeostasis, with additional abnormalities in lipid and protein metabolism. This disorder induces both acute and long-term complications, particularly cardiovascular, with an increased rate of morbidity and mortality as compared to the general population. The incidence and associated complications of the disease are in continuous progression; indeed, by the year 2010, the total number of people with diabetes is projected to reach 221 million, as compared to an estimated 124 million in 1997 (Amos et al. 1997). The prevalence of diabetes in adults worldwide was estimated to be 4.0% in 1995 and to rise to 5.4% by the year 2025 (King et al. 1998).


Fructose Sine Adenine Indomethacin Glucagon 


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Copyright information

© Springer Berlin Heidelberg 2001

Authors and Affiliations

  • P. Petit
    • 1
  • D. Hillaire-Buys
    • 1
  • M.M. Loubatières-Mariani
    • 1
  • J. Chapal
    • 1
  1. 1.Laboratory of Pharmacology (Research Unit UPRES EA 1677), Faculty of MedicineMontpellier I UniversityFrance

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