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Purinergic Receptors and the Pharmacology of Type 2 Diabetes

  • Chapter
Purinergic and Pyrimidinergic Signalling II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 151 / 2))

Abstract

Diabetes mellitus is the phenotypic expression of a disorder resulting from various environmental factors interacting with a genetic component. It is an heterogeneous metabolic syndrome consisting of a dysregulation of glucose homeostasis, with additional abnormalities in lipid and protein metabolism. This disorder induces both acute and long-term complications, particularly cardiovascular, with an increased rate of morbidity and mortality as compared to the general population. The incidence and associated complications of the disease are in continuous progression; indeed, by the year 2010, the total number of people with diabetes is projected to reach 221 million, as compared to an estimated 124 million in 1997 (Amos et al. 1997). The prevalence of diabetes in adults worldwide was estimated to be 4.0% in 1995 and to rise to 5.4% by the year 2025 (King et al. 1998).

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Authors and Affiliations

  1. Laboratory of Pharmacology (Research Unit UPRES EA 1677), Faculty of Medicine, Montpellier I University, France

    P. Petit, D. Hillaire-Buys, M.M. Loubatières-Mariani & J. Chapal

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  1. P. Petit
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  2. D. Hillaire-Buys
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  3. M.M. Loubatières-Mariani
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  4. J. Chapal
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215) 303 East Chicago Avenue, Chicago, IL, 60611

    Michael Williams

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Petit, P., Hillaire-Buys, D., Loubatières-Mariani, M., Chapal, J. (2001). Purinergic Receptors and the Pharmacology of Type 2 Diabetes. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_12

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