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The response of human B lymphocytes to oligodeoxynucleotides

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Immunostimulatory DNA Sequences

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Abstract

Until recently, DNA has generally been viewed as having limited immunogenic potential. Although antibody production could be induced by certain DNA structures, including denatured DNA, Z-DNA, A-DNA, and triple helical DNA [1], it was difficult to induce antibody by immunization with native right-handed helical DNA. Therefore, DNA was generally considered to be poorly immunostimulatory.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., TX, Dallas, 75235-8884, USA

    Hua Liang & Peter E. Lipsky

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  1. Hua Liang
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  2. Peter E. Lipsky
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Editors and Affiliations

  1. Dept. of Medicine-0663, University of California, San Diego, 9500 Gliman Drive, 92093, La Jolla, CA, USA

    Eyal Raz MD

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© 2001 Springer-Verlag Berlin Heidelberg

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Liang, H., Lipsky, P.E. (2001). The response of human B lymphocytes to oligodeoxynucleotides. In: Raz, E. (eds) Immunostimulatory DNA Sequences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56866-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-56866-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63212-9

  • Online ISBN: 978-3-642-56866-4

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