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Rescue of B cells from apoptosis by immune stimulatory CpG DNA

  • Chapter
Immunostimulatory DNA Sequences

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Abstract

All higher multicellular organisms use programmed cell death, or apoptosis, as a way to regulate cell numbers. Apoptosis is used to rid the organism of unneeded cells during development as well as to eliminate infected or damaged cells that could pose a threat to organismal integrity. The immune system also uses apoptosis as a means to regulate cell numbers. For example, at the end of an immune response large numbers of antigen-specific lymphocytes have been generated against an infectious agent. The absence of antigens is a sign to the immune system that the infection has been overcome, and is typically followed by the loss via apoptosis of 90% or more of these newly generated lymphocytes. Apoptosis also plays an extremely important role during the generation of the primary immune repertoire. The immune system typically “uses” antigen-receptor signaling of immature lymphocytes as a sign that these lymphocytes may have a level of reactivity with self-antigens that could lead to the development of autoimmune disease. Such autoreactive lymphocytes are instead purged from the emerging repertoire through apoptosis.

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Author information

Authors and Affiliations

  1. Department of Veterans Affairs Medical Center, IA, Iowa City, 52246, USA

    Arthur M. Krieg

  2. Department of Internal Medicine, University of Iowa College of Medicine, 540 EMRB, IA, Iowa City, 52242, USA

    Arthur M. Krieg

  3. CpG ImmunoPharmaceuticals, MA, Wellesley, 02481, USA

    Arthur M. Krieg

  4. Department of Internal Medicine, University of Iowa College of Medicine, 540 EMRB, IA, Iowa City, 52242, USA

    Ae-Kyung Yi

Authors
  1. Arthur M. Krieg
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  2. Ae-Kyung Yi
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Editor information

Editors and Affiliations

  1. Dept. of Medicine-0663, University of California, San Diego, 9500 Gliman Drive, 92093, La Jolla, CA, USA

    Eyal Raz MD

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© 2001 Springer-Verlag Berlin Heidelberg

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Krieg, A.M., Yi, AK. (2001). Rescue of B cells from apoptosis by immune stimulatory CpG DNA. In: Raz, E. (eds) Immunostimulatory DNA Sequences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56866-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-56866-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63212-9

  • Online ISBN: 978-3-642-56866-4

  • eBook Packages: Springer Book Archive

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