Abstract
Natural products are in high demand as lead structures in the development of new pharmaceuticals and agricultural chemicals. Establishing a pool of natural products of highest attainable chemical diversity is a major strategic approach for screening programs. As sources of natural compounds, living organisms are not able to compete with chemical synthesis (particularly combinatorial chemistry) in the number of compounds provided. However, nature is unequalled by synthetic chemists in its ability to form a tremendous diversity of complex structures. The complexity of natural products often becomes obvious during attempts to produce these compounds using synthetic chemistry. Frequently, considerable effort by numerous research groups is required to synthesize a particular natural product in the laboratory, while the same task is a simple matter for living systems. Consequently, natural products and compounds derived from them are indispensable agents in medicine and agriculture, providing a significantly greater portion of products for pharmacological applications than in the pest-control sector.
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Gräther, O., Schneider, B. (2001). The Metabolic Diversity of Plant Cell and Tissue Cultures. In: Esser, K., Lüttge, U., Kadereit, J.W., Beyschlag, W. (eds) Progress in Botany. Progress in Botany, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56849-7_13
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