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Zusammenfassung

Ausgehend von der ursprünglich pathophysiologisch begründeten Behandlungsbedürftigkeit schwerer, genetisch bedingter Fettstoffwechselstörungen wurde der therapeutische Nutzen einer lipidsen-kenden Arzneitherapie eingehend untersucht. Zahlreiche angiographische und klinische Studien belegen heute, daß ihr Einsatz die Kriterien Evidenz-basierter Medizin bei Patienten mit erhöhtem kardiovaskulären Risiko erfüllt. Weiterhin verbessern lipidsenkende Maßnahmen relevant die Prognose nach Herztransplantation (Kobashigawa et al. 1995, Jaeger et al. 1997).

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Literatur

  • Arzneimittelkommission der deutschen Ärzteschaft (1999): Empfehlungen zur Therapie von Fettstoffwechselstörungen. Arzneiverordnung in der Praxis, Sonderheft 1, 2. Aufl.: 1–16

    Google Scholar 

  • Davies M.J. (1996): Stability and instability: two faces of coronary atherosclerosis. Circulation 94: 2013–2020.

    Article  PubMed  CAS  Google Scholar 

  • Downs J.R., Clearfield M., Weis S., Whitney E., Shapiro D.R. et al. (1998): Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels. JAMA 279: 1615–1622.

    Article  PubMed  CAS  Google Scholar 

  • Enbergs A., Liese A., Heimbach M., Kerber S., Scheid H.H. et al. (1997): Sekundärprävention der koronaren Herzkrankheit auf dem Prüfstand. Ergebnisse der EUROASPIRE-Studie in der Region Münster. Z. Kardiol. 86: 284–291.

    CAS  Google Scholar 

  • Ericsson C.G., Hamsten A., Nilson J., Grip L., Svane B., De Faire U. (1996): Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet 347: 849–853.

    Article  PubMed  CAS  Google Scholar 

  • EUROASPIRE Study Group (1997): EUROASPIRE. A European Society of Cardiology survey of secondary prevention of coronary heart disease: principal results. EUROASPIRE Study Group. European Action on Secondary Prevention through Intervention to Reduce Events. Eur. Heart J. 18: 1569–1582.

    Article  Google Scholar 

  • Helsinki Heart Study (1987): Primary-prevention trial with gemfibrozil in middleaged men with dyslipidemia. N. Engl. J. Med. 317: 1237–1245.

    Article  Google Scholar 

  • Jaeger B.R., Meiser B., Nagel D., Überfuhr P., Thiery J. et al. (1997): Aggressive lowering of fibrinogen and cholesterol in the prevention of graft vessel disease after heart transplantation. Circulation (suppl. II): 11–154–11–158.

    Google Scholar 

  • Kobashigawa J.A., Katznelson S., Laks H. (1995): Effect of pravastatin on outcomes after cardiac transplantation. N. Engl. J. Med. 333: 621–627.

    Article  PubMed  CAS  Google Scholar 

  • Levine G.N., Keaney J.E, Vita J.A. (1995): Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N. Engl. J. Med. 332: 512–522.

    Article  PubMed  CAS  Google Scholar 

  • Lipid Research Clinics Program (1984): Lipid Research Clinics Coronary Primary Prevention Trial Results. I. Reduction in incidence of coronary heart disease. II. Relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 351–364, 365–374.

    Article  Google Scholar 

  • Pearson T.A. (1998): Lipid-lowering therapy in low risk patients. JAMA 279: 1659–1661.

    Article  PubMed  CAS  Google Scholar 

  • Pitt B., Waters D., Brown W.V., van Boven A.J., Schwartz L., Title L.M. et al. (1999): Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. N. Engl. J. Med. 341: 70–76.

    Article  PubMed  CAS  Google Scholar 

  • Pyörälä K., De Backer G., Graham I., Pole-Wilson P., Wood D. (1994): Prevention of coronary heart disease in clinical practice. Eur. Heart J. 15: 1300–1331.

    PubMed  Google Scholar 

  • Pyörälä K., Pedersen R.T., Kjekshus J., Faergeman O., Olsson A.G. et al. (1997): Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. Diabetes Care 20: 614–620.

    Article  PubMed  Google Scholar 

  • Rubins H.B., Robins S.J., Collins D,. Fye C.L., Anderson J.W., Elam M.B. et al. for The Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group (1999): Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N. Engl. J. Med. 341: 410–418.

    Article  PubMed  CAS  Google Scholar 

  • Sacks F.M., Pfeffer M.A., Moye L.A., Rouleau J.L., Rutherford J.D. et al. (1996): The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N. Engl. J. Med. 335: 1001–1009.

    Article  PubMed  CAS  Google Scholar 

  • Scandinavian Simvastatin Survival Study Group (1994): Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease. The Scandinavian Simvastatin Survival Study (4S). Lancet 344: 1383–1389.

    Google Scholar 

  • Shepherd J., Cobbe S.M., Ford I., Isles CG., Lorimer A.R. et al. for the West of Scotland Coronary Prevention Study Group (1995): Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med. 333: 1301–1307.

    Article  PubMed  CAS  Google Scholar 

  • SIGN Publication Number 40 (1999): Lipids and the Primary Prevention of Coronary Heart Disease. SIGN Secretariat, Royal College of Physicians, 9 Queen Street, Edinburgh EH2 1JQ.

    Google Scholar 

  • SIGN Publication Number 41 (2000): Secondary Prevention for Coronary Heart Disease following Myocardial Infacrtion. SIGN Secretariat, Royal College of Physicians, 9 Queen Street, Edinburgh EH2 1JQ.

    Google Scholar 

  • The Long-Term Intervention With Pravastatin in Ischemic Disease (LIPID) Study Group (1998): Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N. Engl. J. Med. 339: 1349–1357.

    Article  Google Scholar 

  • Witztum J.L. (1996): Drugs used in the treatment of hyperlipoproteinemias. In: Hardman J.G. et al. (eds.): Goodman 8c Gilman’s The pharmacological basis of therapeutics, 9th ed., McGraw-Hill, New York, pp. 875–897.

    Google Scholar 

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© 2001 Springer-Verlag Berlin Heidelberg

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Klose, G., Schwabe, U. (2001). Lipidsenkende Mittel. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56832-9_34

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  • DOI: https://doi.org/10.1007/978-3-642-56832-9_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67573-0

  • Online ISBN: 978-3-642-56832-9

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