Skip to main content
  • 78 Accesses

Zusammenfassung

Eine Lebermetastasierung tritt insbesondere bei gastrointestinalen Tumoren auf, da die Leber hier als Filter vorgeschaltet ist. Im Endstadium sind auch bei Lebermetastasen Tumoren anderer Herkunft häufig. So besteht zum Zeitpunkt des tumorbedingten Ablebens bei 60–70% aller an Krebs erkrankten Patienten eine Tumorinfiltration der Leber.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Bown SG (1983) Phototherapy of tumors. World J Surg 7:700–709

    Article  PubMed  CAS  Google Scholar 

  • Cunningham D, Pyrhonen S, James RD, et al., (1998) Randomized trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 352:1413–1418

    Article  PubMed  CAS  Google Scholar 

  • De Gramont A, Vignoud J, Tournigand C, et al., (1997) Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer. Eur J Cancer 33:214–219

    Article  PubMed  Google Scholar 

  • De Gramont A, Figer A, Seymour M, et al., (1998) A randomized trial of leucovorin (LV) and 5-fluorouracil (5-FU) with or without oxaliplatin in advanced colorectal cancer (CRC). Proc Am Soc Clin Oncol 17:257

    Google Scholar 

  • Dominguez S, Denys A, Madeira I, et al., (2000) Hepatic arterial chemoembolization with streptozotocin in patients with metastatic digestive endocrine tumours. Eur J Gastroenterol Hepatol 12:151–157

    Article  PubMed  CAS  Google Scholar 

  • Giovannini M, Seitz FJ (1994) Ultrasound-guided percutaneous alcohol injection of small livermetastases. Results in 40 patients. Cancer 73:294–297

    Article  PubMed  CAS  Google Scholar 

  • Kemeny N, Huang Y, Cohen AM, et al., (1999) Hepatic arterial infusion of chemotherapy after resection of hepatic metastases for colorectal cancer. N Engl J Med 34:2039–2048

    Article  Google Scholar 

  • Kirchhoff T, Chavan A, Galanski M (1998) Transarterial chemoembolization and percutaneous ethanol injection therapy in patients with hepatocellular carcinoma. Eur J Gastroenterol Hepatol 10:907–909

    Article  PubMed  CAS  Google Scholar 

  • Köhne-Wömpner CH (1992) Chemotherapeutic strategies in metastatic colorectal cancer: An overview of current clinical trials. Semin Oncol 19[Suppl 3]: 105–125

    PubMed  Google Scholar 

  • Livraghi T (1993) Ultrasound guided percutaneous ethanol injection therapy of hepatic tumors and metastases. Z Gastroenterol 31:260–264

    PubMed  CAS  Google Scholar 

  • Lorenz M, Rossion I (1995) Adjuvante und palliative regionale Therapie von Lebermetastasen kolorektaler Tumoren. Dtsch Med Wochenschr 120:690–697

    Article  PubMed  CAS  Google Scholar 

  • Lorenz M, Hottenrott C, Liermann D, et al., (1991) Selektive Chemoembolisation von primären und sekundären Lebermalignomen mit Mitomycin C, Lipiodol und Dura. In: Herfarth C, Schlag P (Hrsg) Neue Entwicklungen in der Therapie von Lebertumoren. Springer, Berlin Heidelberg New York, S 73–85

    Google Scholar 

  • Lorenz M, Müller HH, Schramm H, et al., (1998a). Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. Ann Surg 228:756–762

    Article  PubMed  CAS  Google Scholar 

  • Lorenz M, Staib-Sebler E, Gog C, et al., (1998b) A pilot study on intense weekly 24-hour intraarterial infusion with 5-fluorouracil and folinic acid for colorectal liver metastases. Oncology 55:53–58

    Article  PubMed  CAS  Google Scholar 

  • Lorenz M, Müller HH for the German Cooperative Group on Liver Metastases (ALM) (2000) Randomized, multicenter trial of 5-fluorouracil plus leucovorin administered via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with non-resectable liver metastases from colorectal carcinoma. J Clin Oncol 18:243

    PubMed  CAS  Google Scholar 

  • Meta-Analysis Group In Cancer (1996) Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer. J Natl Cancer Inst 88:252–258

    Article  Google Scholar 

  • Nordic Gastrointestinal Tumour Adjuvant Therapy Group (1992) Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: a randomised trial.Clin Oncol 10:904–911

    Google Scholar 

  • Ravikumar TS, Kane R, Cady B, et al., (1991) A 5-year study of cryosurgery in the treatment of liver tumors. Arch Surg 126:1520–1524

    Article  PubMed  CAS  Google Scholar 

  • Rossi S, Stasi M, Carini E, Quaretti P, et al., (1996) Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. Am J Roentgenol 167:759–768

    CAS  Google Scholar 

  • Rougier P, Van Cutsem E, Bajetta E, et al., (1998) Randomised trial of irinotecan versus fluorouracil by continuous infusion in fluorouracil failure in patients with metastatic colorectal cancer. Lancet 352:1407–1412

    Article  PubMed  CAS  Google Scholar 

  • Scheithauer W, Rosen H, Kornek GV, et al., (1993) Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal disease. BMJ 306:752–755

    Article  PubMed  CAS  Google Scholar 

  • Staib-Sebler E, Lorenz M, Gog C, Encke A (1995) Continuous arterial 5-fluorouracil and folinic acid chemotherapy for colorectal liver metastases. Oncology 18:240–244

    Article  Google Scholar 

  • Stangl R, Altendorf Hofmann A, Charnley RM, Scheele J (1994) Factors influencing the natural history of colorectal liver metastases. Lancet 343:1405–1410

    Article  PubMed  CAS  Google Scholar 

  • Vogl TJ, Müller PK, Hammerstingl R, et al., (1995) Malignant liver tumor treatment with MR imaging-guided laser-induced thermotherapy: technique and prospective results. Radiology 196:257–265

    PubMed  CAS  Google Scholar 

  • Vogl TJ, Mack MG, Straub R, et al., (1997) Percutaneous MRI-guided laser-induced thermotherapy for hepatic metastases for colorectal cancer. Lancet 350:29

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lorenz, M., Sahm, S.W., Mack, M., Vogl, T.J. (2001). Lebermetastasen. In: Caspary, W.F., Leuschner, U., Zeuzem, S. (eds) Therapie von Leber- und Gallekrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56819-0_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56819-0_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63151-1

  • Online ISBN: 978-3-642-56819-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics