Zusammenfassung

Das Körpergewicht des Menschen ist das Ergebnis einer langfristigen Energiebilanz. Unabhängig von seiner aktuellen Höhe wird das Körpergewicht in engen Grenzen reguliert. Nach kurzfristiger Überoder Unterernährung kommt es über potente Adaptationsmechanismen spontan zur raschen Wiederherstellung des Ausgangsgewichts. Stabile Veränderungen des Körpergewichts können nur bei langfristigem Ungleichgewicht zwischen Energieaufnahme und Energieverbrauch entstehen.

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Literatur

  1. Ahima R.S., Prabakaran D., Mantzoros C. et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382: 250–252PubMedCrossRefGoogle Scholar
  2. Auwerx J., Staels B. (1998) Leptin 351: 737–742Google Scholar
  3. Beumont P.J.V., Russell J.D., Touyz S.W. (1993) Treatment of anorexia nervosa. Lancet 341: 1635–1640PubMedCrossRefGoogle Scholar
  4. Bouchard C., Perusse L., Rice T., Rao D.C. (1998) The genetics of human obesity. In: Bray G.A., Bouchard C., James W.P.T. (eds) Handbook of Obesity. Dekker, New York, p 157–190Google Scholar
  5. Cahill G.F. (1970) Starvation in man. N Engl J Med 282: 668–675PubMedCrossRefGoogle Scholar
  6. Colditz G.A., Willett W.C., Rotnitzky A., Manson J.E. (1995) Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122: 481–485PubMedCrossRefGoogle Scholar
  7. Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity (1995) Weighing the options: criteria for evaluating weight-management programs. Ob es Res 3: 591–604CrossRefGoogle Scholar
  8. Considine R.V., Sinha M.K., Heiman M.L. et al. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292–295PubMedCrossRefGoogle Scholar
  9. Flier J.S., Maratos-Flier E. (1998) Obesity and the hypothalamus: novel peptides from new pathways. Cell 92: 437–440PubMedCrossRefGoogle Scholar
  10. Garner D.M. (1993) Pathogenesis of anorexia nervosa. Lancet 341: 1631–1635PubMedCrossRefGoogle Scholar
  11. Hauner D., Hauner H. (1996) Leichter durchs Leben. Ratgeber für Ubergewichtige. Trias Verlag StuttgartGoogle Scholar
  12. Hauner H. (1997) Strategie der Adipositastherapie. Internist 38: 244–250PubMedCrossRefGoogle Scholar
  13. Hauner H., Westenhöfer J., Wirth A., Lauterbach (1998) Adipositas-Leitlinie für den behandelnden Arzt. Anwenderversion der Evidenz-basierten Leitlinie zur Behandlung der Adipositas in DeutschlandGoogle Scholar
  14. Husemann B. (1997) Die chirurgische Therapie der extremen Adipositas. Dtsch Arztebl 94:C1603–C1607Google Scholar
  15. Katan M.B., Grundy S.M., Willett W.C. (1997) Beyond low-fat diets. N Engl J Med 337: 563–566PubMedGoogle Scholar
  16. Lichtman S.W., Pisarska K., Berman E.R. et al. (1992) Discrepancy between self-reported and actual caloric in take and exercise in obese subjects. N Engl J Med 327: 1893–1898PubMedCrossRefGoogle Scholar
  17. Lissner L., Heitmann B.L. (1995) The dietary fat:carbohydrate ratio in relation to body fat. Curr Opin Lipidol 6: 8–13PubMedCrossRefGoogle Scholar
  18. Manson J.E., Willett W.C., Stampfer M.J. et al. (1995) Body weight and mortality among women. N Engl J Med 333: 677–685PubMedCrossRefGoogle Scholar
  19. Montague C.T., Farooqi I.S., Whitehead J.P. et al. (1997) Congenitalleptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903–907PubMedCrossRefGoogle Scholar
  20. Ravussin E., Swinburn B.A. (1992) Pathophysiology of obesity. Lancet 340: 404–408PubMedCrossRefGoogle Scholar
  21. Rössner S. (1992) Factors determining the long-term outcome of obesity treatment. In: Björntorp P., Brodoff B.N. (eds) Obesity. Lippincott, Philadelphia, pp 712–719Google Scholar
  22. Shah M., Garg A. (1996) High-fat and high-carbohydrate diets and energy balance. Diabetes Care 19: 1142–1152PubMedCrossRefGoogle Scholar
  23. Stevens J., Cai J., Pamuk E.R. et al. (1998) The effect of age on the association between body-mass index and mortality. N Engl J Med 338: 1–7PubMedCrossRefGoogle Scholar
  24. Wechsler J.G., Schusdziarra V., Hauner H., Gries F.A. (1997) Therapie der Adipositas. Dtsch Ärztebl 93:C1518–C1520Google Scholar
  25. Woods S.C., Seeley R.J., Porte D., Schwartz M.W. (1998) Signals that regulate food in take and energy homeostasis. Science 280: 1378–1282PubMedCrossRefGoogle Scholar
  26. Westenhöfer J. (1996) Essstörungen. Akt Ernähr Med 21: 235–242Google Scholar
  27. Wirth A. (1997) Adipositas. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  28. World Health Organization (1998) Obesity-Preventing and managing the global epidemic. WHO Geneva, im DruckGoogle Scholar
  29. Yanovski S.Z. (1998) Obesity and Eating Disorders. In: Bray G.A., Bouchard C., James W.P.T. (eds) Handbook of Obesity. Dekker, New York, pp 115–128Google Scholar
  30. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432PubMedCrossRefGoogle Scholar
  31. Zipfel S., Löwe B., Reas D.L., Deter H-C., Herzog W. (2000) Longterm prognosis in anorexia nervosa: Lessons from a 21-year follow-up study. Lancet 355: 721–722PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • H. Hauner

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