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Nuclear Export of Adenovirus RNA

  • Chapter
Nuclear Export of Viral RNAs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 259))

Abstract

Adenoviruses are medium-sized, non-enveloped DNA viruses which nowadays include well over 100 different serotypes found in a wide range of mammalian and avian hosts. The human adenoviruses comprise over 47 different serotypes which cause lytic and persistent infections and have been associated with a variety of clinical syndromes (reviewed in Horwitz 1996). Following their discovery in latently infected adenoids more than 45 years ago, human adenoviruses stepped into the limelight of molecular virology when it was found that certain serotypes have oncogenic potential in newborn rodents and that all human adenoviruses can transform primary rodent cells in culture. These findings in particular inspired a period of intense research on adenovirus biology that contributed enormously to a molecular understanding of normal and malignant cell growth. In addition, studies on adenovirus productive infection in cultured cells have provided important insight into fundamental mechanisms in molecular biology, perhaps most notably, mRNA splicing. While these viruses still serve as a laboratory model to solve the mysteries of cell growth control, they are now being used in pre-clinical and clinical trials as vectors for gene therapy and more recently as oncolytic vehicles for the treatment of human cancer (reviewed in Bilbao et al. 1998; Benihoud et al. 1999).

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Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    T. Dobner & J. Kzhyshkowska

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  1. T. Dobner
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  2. J. Kzhyshkowska
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  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Schlossgarten 4, 91054, Erlangen, Germany

    Joachim Hauber

  2. Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt

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Dobner, T., Kzhyshkowska, J. (2001). Nuclear Export of Adenovirus RNA. In: Hauber, J., Vogt, P.K. (eds) Nuclear Export of Viral RNAs. Current Topics in Microbiology and Immunology, vol 259. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56597-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-56597-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62522-0

  • Online ISBN: 978-3-642-56597-7

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