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Nuclear Export of Herpes Virus RNA

  • Chapter
Nuclear Export of Viral RNAs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 259))

Abstract

Eukaryotic mRNA Precursors are synthesized in the nucleus by RNA polymerase II, after which they are processed by cappng at the 5′ end, cleavage and polyadenylation to form the 3′ end, and splicing to remove intro sequences. Following these processing events, the mRNA molecules are transported to the cytoplasm where they are translated. The exclange of macromolecules between the nucleus and cytoplasm occurs through nuclear pore complexes NPCs), RNA molecules leave the nucleus though an active, energy-dependent, saturable mechanism (for review, see Nakielny et al. 1997; Mattaj and Englmeier 1998; Ullman et al. 1997; Gorlich 1998). RNA export through the NPC is mediated by proteins (adapters) associated with the RNAs, and these proteins contain signals to use receptor-mediated export through the NPC to transport their cargo (for review, see Stutz and Rosbash 1998). A feature of these proteins is that they shuttle contiuously between the nucleus and the cytoplasm, because these export proteins contain a sequence that signal their import into the nucleus, termed a nuclear localization signal (NLS), as well as a sequence that signals their export from the nucleus, termed a nuclear export signal (NES). Regulation of both nuclear import and nuclear export is mainly exerted at the level of transport complex formation. Some of the receptor proteins with which these shuttling export proteins interact have been defined. However, studies on the composition of the NPC, interactions of receptor-cargo complexes with nucleoporin components of the NPC, and the regulation of export and import have only begun to elucidate the transport process.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, College of Medicine, Medical Sciences I, B240, University of California, Irvine, Irvine, CA, 92697-4025, USA

    R. M. Sandri-Goldin

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  1. R. M. Sandri-Goldin
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  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Schlossgarten 4, 91054, Erlangen, Germany

    Joachim Hauber

  2. Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt

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Sandri-Goldin, R.M. (2001). Nuclear Export of Herpes Virus RNA. In: Hauber, J., Vogt, P.K. (eds) Nuclear Export of Viral RNAs. Current Topics in Microbiology and Immunology, vol 259. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56597-7_1

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  • DOI: https://doi.org/10.1007/978-3-642-56597-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62522-0

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