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Grundlagen der Testosterontherapie

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Der alternde Mann
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Zusammenfassung

Die Unterfunktion der Hoden beim Mann wird als Hypogonadismus bezeichnet. Die daraus resultierenden Störungen konnen sowohl isolierte Defekte der endokrinen Funktionen (z. B. Androgenmangel) betreffen alsauch zu Veränderungen der exokrinen Hodenfunktion führen, wobei auch Kombinationen der funktionellen Ausfälle beider Systeme vorliegen können. Je nach Lokalisation der Veränderungen spricht man von primärem (testikulären) oder sekundärem Hypogonadismus (hypothalamo- hypophysärer Hypergonadismus, Tab. 6).

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Literatur

  1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB: Impotence and its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study. J Urol (1994) 54–61

    Google Scholar 

  2. Luo L, Chen H, Zirkin BR: Are Leydig cell steroidogenic enzymes differentially regulated with aging? J Androl (1996) 17:509–515

    PubMed  CAS  Google Scholar 

  3. Tenover J: Androgen Deficiency in Aging Men. In: Waites GMH, Frick J, Baker GWH (Eds.): Current Advances in Andrology, Monduzzi Editore S.p.A., Bologna (1997) 276–288

    Google Scholar 

  4. Vermeulen A: Androgens in the aging male — Clinical review. J Clin Endocrinol Metab. (1991) 73:221–224

    Article  PubMed  CAS  Google Scholar 

  5. Morales A, Heaton JP, Carson CC III: Andropause: a misnomer for a true clinical entity. J Urol (2000) 163:705–712

    Article  PubMed  CAS  Google Scholar 

  6. Vermeulen A, Kaufman JM: Role of the hypothalamo-pituitary function in the hypoandrogenism of healthy aging. J Clin Endocrinol Metab. (1992) 74:1226A–1226C

    Google Scholar 

  7. Hoffner SM: Androgens in relation to cardiovascular disease and insulin resistance in aging men, In: B. Oddens, A. Vermeulen (Eds.): Androgens and the Aging Male. Parthenon Publishing Group, New York (1996) 65–93

    Google Scholar 

  8. Kaufman JM: Androgens, bone metabolism and osteoporosis, In: B. Oddens, A. Vermeulen (Eds.): Androgens and the Aging Male. Parthenon Publishing Group, New York (1996) 39–60

    Google Scholar 

  9. Rommerts FFG: Testosterone: An overview of biosythesis, transport, metabolism and nongenomic action. In: E. Nieschlag, H.M. Behre (Eds. ): Testosterone. Action-DeficiencySubstitution, Springer Verlag Berlin-Heidelberg (1998)

    Google Scholar 

  10. Christiansen K: Behavioural correlates of testosterone. In: E. Nieschlag, H.M. Behre (Eds.): Testosterone. Action-Deficiency-Substitution, Springer Verlag Berlin-Heidelberg (1998)

    Google Scholar 

  11. Gray A, Berlin JA, McKinlay JB, Longcope: An examination of research design effects on the association of testosterone and male aging. Results of a meta-analysis. J Clin Epidemiol (1991) 44:671–684

    Article  PubMed  CAS  Google Scholar 

  12. Gooren LJ: Endocrine aspects of aging in the male. Mol Cell Endocrinol (1998) 25:153–159

    Article  Google Scholar 

  13. Ebeling PR: Osteoporosis in men. New insights into aetiology, pathogenesis, prevention and management. Drugs-Aging (1998) 13:421–434

    Article  PubMed  CAS  Google Scholar 

  14. Sternbach H: Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry (1998) 155:1310–1318

    PubMed  CAS  Google Scholar 

  15. Maas O, Jochen A, Lalande B: Age-releated chances in male gonadal function. Implication for therapy. Drugs Aging (1997) 11:45–60

    Article  PubMed  CAS  Google Scholar 

  16. Vermeulen A, Kaufman JM, Giagulli VA: Influence of some biological indices on sex hormone binding globulin and androgen levels in aging and obese males. J Clin Endocrinol Metab (1996) 81:1821–1827

    Article  PubMed  CAS  Google Scholar 

  17. Barrett-Connor E. et al.: Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study. J Clin Endocrinol Metab (1999) 84:573–577

    Article  PubMed  CAS  Google Scholar 

  18. Baumgartner RN et al.: Predictors of skeletal muscle mass in elderly men and woman., Mech. Ageing Dev (1999) 107:123–136

    Article  PubMed  CAS  Google Scholar 

  19. Clague JE et al.: Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men. Int J Androl (1999) 22:261–265

    Article  PubMed  CAS  Google Scholar 

  20. Ferrini RL, Barrett-Connor E: Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwellingmen. Am J Epidemiol15, (1999) 147:750–754

    Article  Google Scholar 

  21. Howell SJ et al.: Testicular function after cytotoxic chemotherapy: evidence of Leydig ell insufficiency. J Clin Oncol (1999) 17:1493–1498

    PubMed  CAS  Google Scholar 

  22. Khosla S et al.: Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and woman: a key role for bioavailable estrogen. J Clin Endocrinol Metab (1998) 83:2266–2274

    Article  PubMed  CAS  Google Scholar 

  23. Krithivas K et al.: Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men. J Endocrinol (1999) 162:137–142

    Article  PubMed  CAS  Google Scholar 

  24. McKinlay JB et al.: The questionable physiologic and epidemiologic basis for a male climacteric syndrome: preliminary results from the Massachusetts Male Aging Study. Maturitas (1989) 11:103–115

    Article  PubMed  CAS  Google Scholar 

  25. Morley JE et al.: Longitudinal changes in testosterone, luteinizing hormone, and folliclestimulating hormone in healthy older men. Metabolism (1997) 46:410–413

    Article  PubMed  CAS  Google Scholar 

  26. Nyquist F et al.: Assessment of sex hormones and bone mineral density in relation to occurrence of fracture in men: a prospective population-based study. Bone (1998) 22:147–151

    Article  PubMed  CAS  Google Scholar 

  27. Price JF et al.: Steroid sex hormones and peripheral arterial disease in the Edinburgh Artery Study. Steroids (1997) 62:789–794

    Article  PubMed  CAS  Google Scholar 

  28. Rosano GM et al.: Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation (1999) 6:1666–1670

    Article  Google Scholar 

  29. Schweiger U et al.: Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom. Med (1999) 61:292–296

    Google Scholar 

  30. Veldhuis JD et al.: Differential sex steroid negative feedback regulation of pulsatile follicle-stimulating hormone secretion in healthy older men: deconvolution analysis and steady-state sex-steroid hormone infusions in frequently sampled healthy older individuals. J Clin Endocrinol Metab (1997) 82:1248–1254

    Article  PubMed  CAS  Google Scholar 

  31. Vermeulen A et al.: Testosterone, body composition and aging. J Endocrinol Invest (1999) 5 (Suppl.) 22: 110–116

    Google Scholar 

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© 2001 D. Fahlenkamp, K. J. G. Schmailzl, S. Lenk

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Lenk, S. (2001). Grundlagen der Testosterontherapie. In: Der alternde Mann. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56524-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-56524-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62571-8

  • Online ISBN: 978-3-642-56524-3

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