Abstract
Malignant lymphoma is one of the most common malignancies that associate with AIDS (acquired immunodeficiency syndrome) (Herndier et al. 1994; Knowles 1999). The revised criteria for the diagnosis of AIDS by the Centers for Disease Control and Prevention (CDC) in 1987 includes diffuse aggressive intermediate -or high-grade non-Hodgkin’s lymphoma (NHL) of B-cell or indeterminate phenotype as one of the major complications in human immunodeficiency virus (HIV)-infected individuals (CDC 1987). Recently, the introduction of highly active anti-retroviral therapy (HAART) has dramatically decreased various complications in AIDS patients. In contrast, however, the incidence of AIDS lymphoma did not decrease as did the other complications (Franceschi et al. 1999; Grulich 1999).
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References
Andre S, Schatz O, Bogner JR, Zeichhardt H, Stoffler MM, Jahn HU, Ullrich R, Sonntag AK, Kehm R,Haas J (1997) Detection of antibodies against viral capsid proteins of human herpesvirus 8 in AIDS-associated Kaposi’s sarcoma. J Mol Med 75:145–152
Ballerini P, Gaidano G, Gong JZ, Tassi V, Saglio G, Knowles DM, Dalla-Favera R (1993) Multiple genetic lesions in acquired immunodeficiency syndrome-related non-Hodgkin’s lymphoma. Blood 81:166–176
Ballestas ME, Chatis PA, Kaye KM (1999) Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284:641–644
Bashir R, Okano M, Kleveland K, Pirrucello S, Masih A, Sanger W, Fordyce-Boyer R, Purtilo D (1991) SCID/human mouse model of central nervous system lymphoproliferative disease. Lab Invest 65:702–709
Beral V, Peterman T, Berkelman R, Jaffe H (1991) AIDS-associated non-Hodgkin lymphoma. Lancet 337:805–809
Billaud M, Rousset F, Calender A, Cordier M, Aubry JP, Laisse V, Lenoir GM (1990) Low expression of lymphocyte function-associated antigen (LFA)-1 and LFA-3 adhesion molecules is a common trait in Burkitt’s lymphoma associated with and not associated with Epstein-Barr virus. Blood 75:1827–1833
Boshoff C, Gao SJ, Healy LE, Matthews S, Thomas AJ, Coignet L, Warnke RA, Strauchen JA, Matutes E, Kamel OW, Moore PS, Weiss RA, Chang Y (1998) Establishing a KSHV + cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood 91:1671–1679
Buchbinder AQHY, Cockerell CJ, Friedman-Kien AE (1996) “Clinical manifestations and histopathologic features of classic, endemic African, and epidemic AIDS-associated Kaposi’s sarcoma”. In:Friedmann-Kien AE, Cockerell CJ (eds) Color atlas of AIDS, 2nd edn. Saunders WB Company,Philadelphia
Buske C, Hannig H, Hiddemann W, Bodemer W (1997) Human herpesvirus-8 (HHV-8) DNA associated with anaplastic large cell lymphoma of the B-cell type in an HIV-1-positive patient. Int J Cancer 73:303–304
Camilleri-Broet S, Davi F, Feuillard J, Bourgeois C, Seilhean D, Hauw JJ, Raphael M (1995) High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas. Blood 86:432–435
Camilleri-Broet S, Davi F, Feuillard J, Seilhean D, Michiels JF, Brousset P, Epardeau B, Navratil E,Mokhtari K, Bourgeois C, Marelle L, Raphael M, Hauw JJ (1997) AIDS-related primary brain lymphomas: histopathologic and immunohistochemical study of 51 cases. The French Study Group for HIV-Associated Tumors. Hum Pathol 28:367–374
Carbone A, Cilia AM, Gloghini A, Canzonieri V, Pastore C, Todesco M, Cozzi M, Perin T, Volpe R,Pinto A, Gaidano G (1997a) Establishment of HHV-8-positive and HHV-8-negative lymphoma cell lines from primary lymphomatous effusions. Int J Cancer 73:562–569
Carbone A, Cilia AM, Gloghini A, Capello D, Todesco M, Quattrone S, Volpe R, Gaidano G (1998) Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8. Br J Haematol 102:1081–1089
Carbone A, Gaidano G, Gloghini A, Pastore C, Saglio G, Tirelli U, Dalla-Favera R, Falini B (1997b) BCL-6 protein expression in AIDS-related non-Hodgkin’s lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression. Am J Pathol 150:155–165
Centers for Disease Control and Prevention (1987) Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial Epidemiologists; AIDS Program, Center for Infectious Diseases. MMWR Morb Mortal Wkly Rep 36 Suppl 1:1S–15S
Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM (1995) Kaposi’s sarcoma-associated herpes-virus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332:1186–1191
Chadburn A, Cesarman E, Jagirdar J, Subar M, Mir RN, Knowles DM (1993) CD30 (Ki-1) positive anaplastic large cell lymphomas in individuals infected with the human immunodeficiency virus.Cancer 72:3078–3090
Chaganti RS, Jhanwar SC, Koziner B, Arlin Z, Mertelsmann R, Clarkson BD (1983) Specific translocations characterize Burkitt’s-like lymphoma of homosexual men with the acquired immunodeficiency syndrome. Blood 61:1265–1268
Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 266:1865–1869
Chatlynne LG, Lapps W, Handy M, Huang YQ, Masood R, Hamilton AS, Said JW, Koeffler HP,Kaplan MH, Friedman KA, Gill PS, Whitman JE, Ablashi DV (1998) Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi’s sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Blood 92:53–58
Chen KT (1984) Multicentric Castleman’s disease and Kaposi’s sarcoma. Am J Surg Pathol 8:287–293
Cossman J, Annunziata CM, Barash S, Staudt L, Dillon P, He WW, Ricciardi-Castagnoli P, Rosen CA,Carter KC (1999) Reed-Sternberg cell genome expression supports a B-cell lineage. Blood 94:411–416
Davis DA, Humphrey RW, Newcomb FM, O’Brien TR, Goedert JJ, Straus SE, Yarchoan R (1997) Detection of serum antibodies to a Kaposi’s sarcoma-associated herpesvirus-specific peptide. J Infect Dis 175:1071–1079
Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM (1997) Control of inflammation, cytokine expression,and germinal center formation by BCL-6. Science 276:589–592
DePond W, Said JW, Tasaka T, de Vos S, Kahn D, Cesarman E, Knowles DM, Koeffler HP (1997) Kaposi’s sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas.Am J Surg Pathol 21:719–724
Dupin N, Fisher C, Kellam P, Ariad S, Tulliez M, Franck N, van ME, Salmon D, Gorin I, Escande JP,Weiss RA, Alitalo K, Boshoff C (1999) Distribution of human herpesvirus-8 latently infected cells in Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Proc Natl Acad Sci USA 96:4546–4551
Dupin N, Grandadam M, Calvez V, Gorin I, Aubin JT, Havard S, Lamy F, Leibowitch M, Huraux JM,Escande JP, Agut H (1995) Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi’s sarcoma. Lancet 345:761–762
Falk S, Schmidts HL, Muller H, Berger K, Schneider M, Schlote W, Helm EB, Stille W, Hubner K, Stutte HJ (1987) Autopsy findings in AIDS - a histopathological analysis of fifty cases. Klin Wochenschr 65:654–663
Franceschi S, Dal Maso L, La Vecchia C (1999) Advances in the epidemiology of HIV-associated non-Hodgkin’s lymphoma and other lymphoid neoplasms. Int J Cancer 83:481–485
Frizzera G, Banks PM, Massarelli G, Rosai J (1983) A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am J Surg Pathol 7:211–231
Fujii T, Taguchi H, Katano H, Mori S, Nakamura T, Nojiri N, Nakajima K, Tadokoro K, Juji T,Iwamoto A (1998) Seroprevalance of HHV-8 in HIV-1 positive and negative populations in Japan.J Med Virol 57:159–162
Gaidano G, Carbone A, Dalla-Favera R (1998) Pathogenesis of AIDS-related lymphomas: molecular and histogenetic heterogeneity. Am J Pathol 152:623–630
Gaidano G, Carbone A, Pastore C, Capello D, Migliazza A, Gloghini A, Roncella S, Ferrarini M,Saglio G, Dalla-Favera R (1997a) Frequent mutation of the 5’ noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin’s lymphomas. Blood 89:3755–3762
Gaidano G, Cechova K, Chang Y, Moore PS, Knowles DM, Dalla FR (1996) Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia 10:1237–1240
Gaidano G, Gloghini A, Gattei V, Rossi MF, Cilia AM, Godeas C, Degan M, Perin T, Canzonieri V, Aldinucci D, Saglio G, Carbone A, Pinto A (1997b) Association of Kaposi’s sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood 90:4894–4900
Gaidano G, Lo Coco F, Ye BH, Shibata D, Levine AM, Knowles DM, Dalla-Favera R (1994) Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome- associated non-Hodgkin’s lymphoma: association with diffuse large-cell subtype. Blood 84:397–402
Gao SJ, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS (1997) KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene 15:1979–1985
Groopman JE, Sullivan JL, Mulder C, Ginsburg D, Orkin SH, O’Hara CJ, Falchuk K, Wong-Staal F, Gallo RC (1986) Pathogenesis of B-cell lymphoma in a patient with AIDS. Blood 67:612–615
Grulich AE (1999) AIDS-associated non-Hodgkin’s lymphoma in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 21 Suppl 1:S27–S30
Guarner J, del Rio C, Carr D, Hendrix LE, Eley JW, Unger ER (1991) Non-Hodgkin’s lymphomas in patients with human immunodeficiency virus infection. Presence of Epstein-Barr virus by in situ hybridization, clinical presentation, and follow-up. Cancer 68:2460–2465
Hamilton-Dutoit SJ, Pallesen G, Franzmann MB, Karkov J, Black F, Skinhoj P, Pedersen C (1991) AIDS-related lymphoma. Histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization. Am J Pathol 138:149–163
Hamilton-Dutoit SJ, Raphael M, Audouin J, Diebold J, Lisse I, Pedersen C, Oksenhendler E, Marelle L, Pallesen G (1993a) In situ demonstration of Epstein-Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site. Blood 82:619–624
Hamilton-Dutoit SJ, Rea D, Raphael M, Sandvej K, Delecluse HJ, Gisselbrecht C, Marelle L, van Krieken HJ, Pallesen G (1993b) Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin’s lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency. Am J Pathol 143:1072–1085
Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De W, Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink HK, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361–1392
Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, Kieff E, Rickinson A (1991) Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65:1107–1115
Herndier BG, Kaplan LD, McGrath MS (1994) Pathogenesis of AIDS lymphomas. AIDS 8:1025–1049
Herndier BG, Sanchez HC, Chang KL, Chen YY, Weiss LM (1993) High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of HIV-associated Hodgkin’s disease. Am J Pathol 142:1073–1079
Itoh T, Shiota M, Takanashi M, Hojo I, Satoh H, Matsuzawa A, Moriyama T, Watanabe T, Hirai K, Mori S (1993) Engraftment of human non-Hodgkin lymphomas in mice with severe combined immunodeficiency. Cancer 72:2686–2694
Kaposi M (1872) Idiopatiches multiples pigment sarcom der Haut. Arch Dermatol Syphil 4:265–272
Katano H, Hoshino Y, Morishita Y, Nakamura T, Satoh H, Iwamoto A, Herndier B, Mori S (1999a) Establishing and characterizing a CD30-positive cell line harboring HHV-8 from a primary effusion lymphoma. J Med Virol 58:394–401
Katano H, Morishita Y, Cui LX, Watanabe T, Hirai K, Mori S (1996) Expression of latent membrane protein 1 in clinically isolated cases and animal models of AIDS-associated non-Hodgkin’s lymphomas. Pathol Int 46:568–574
Katano H, Sata T, Suda T, Nakamura T, Tachikawa N, Nishizumi H, Sakurada S, Hayashi Y, Koike M, Iwamoto A, Kurata T, Mori S (1999b) Expression and antigenicity of human herpesvirus 8 encoded ORF59 protein in AIDS-associated Kaposi’s sarcoma. J Med Virol 59:346–355
Katano H, Sato Y, Kurata T, Mori S, Sata T (1999c) High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi’s sarcoma. Am J Pathol 155:47–52
Katano H, Sato Y, Kurata T, Mori S, Sata T (2000a) Expression and Localization of Human Herpesvirus 8-Encoded Proteins in Primary Effusion Lymphoma, Kaposi’s Sarcoma and Multicentric Castleman’s Disease. Virology 266:335–344
Katano H, Suda T, Morishita Y, Yamamoto K, Hoshino Y, Nakamura K, Tachikawa N, Sata T, Hamaguchi H, Iwamoto A, Mori S (2000b) HHV-8-associated solid lymphomas occurring in AIDS patients take anaplastic large cell morphology. Mod Pathol 13:77–85
Kedes DH, Ganem D, Ameli N, Bacchetti P, Greenblatt R (1997) The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women. JAMA 277:478–481
Khanna R, Burrows SR, Nicholls J, Poulsen LM (1998) Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes. Eur J Immunol 28:451–458
Klatt EC, Nichols L, Noguchi TT (1994) Evolving trends revealed by autopsies of patients with the acquired immunodeficiency syndrome. 565 autopsies in adults with the acquired immunodeficiency syndrome, Los Angeles, Calif, 1982–1993. Arch Pathol Lab Med 118:884–890
Knowles DM (1999) Immunodeficiency-associated lymphoproliferative disorders. Mod Pathol 12: 200–217
Komano J, Maruo S, Kurozumi K, Oda T, Takada K (1999) Oncogenic role of epstein-barr virus-encoded RNAs in Burkitt’s lymphoma cell line akata. J Virol 73:9827–9831
MacMahon EM, Glass JD, Hayward SD, Mann RB, Becker PS, Charache P, McArthur JC, Ambinder RF (1991) Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet 338:969–973
Mayama S, Cuevas LE, Sheldon J, Omar OH, Smith DH, Okong P, Silvel B, Hart CA, Schulz TF (1998) Prevalence and transmission of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 77:817–820
Meeker TC, Shiramizu B, Kaplan L, Herndier B, Sanchez H, Grimaldi JC, Baumgartner J, Rachlin J, Feigal E, Rosenblum M, McGrath MS (1991) Evidence for molecular subtypes of HIV-associated lymphoma: division into peripheral monoclonal, polyclonal and central nervous system lymphoma. AIDS 5: 669–674
Melbye M, Cook PM, Hjalgrim H, Begtrup K, Simpson GR, Biggar RJ, Ebbesen P, Schulz TF (1998) Risk factors for Kaposi’s-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981–1996. Int J Cancer 77:543–548
Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R (1995) Frequent somatic hypermutation of the 5’ noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 92:12520–12524
Miles SA, Rezai AR, Salazar GJ, Vander MM, Stevens RH, Logan DM, Mitsuyasu RT, Taga T, Hirano T, Kishimoto T, Martinez-Maza O (1990) AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc Natl Acad Sci USA 87(11):4068–4072
Mohar A, Romo J, Salido F, Jessurun J, Ponce de Leon S, Reyes E, Volkow P, Larraza O, Peredo MA, Cano C, Gomez G, Sepulveda J, Mueller N (1992) The spectrum of clinical and pathological manifestations of AIDS in a consecutive series of autopsied patients in Mexico. AIDS 6:467–473
Moore PS, Boshoff C, Weiss RA, Chang Y (1996) Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274:1739–1744
Moore PS, Chang Y (1995) Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma in patients with and without HIV infection. N Engl J Med 332:1181–1185
Mori S, Koike M, Hondo R, Wakabayashi T, Maeda Y, Kazuyama Y, Kataoka I, Watanabe T (1991) Malignant lymphomas in Japanese AIDS patients. Acta Pathol Jpn 41:744–750
Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E (1995) The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389–399
Murray RJ, Kurilla MG, Brooks JM, Thomas WA, Rowe M, Kieff E, Rickinson AB (1992) Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies. J Exp Med 176:157–168
Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Sald J, Knowles DM (1996) Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus. Blood 88:645–656
Nakamura K, Katano H, Hoshino Y, Nakamura T, Hosono O, Masunaga A, Mori S, Iwamoto A, Tamaki K (1999) Human herpesvirus type 8 (HHV-8) and Epstein-Barr virus (EBV)-associated cutaneous lymphoma taking anaplastic large cell morphology in an HIV-positive patient. Br J Dermatol 141:141–145
Nosari A, Cantoni S, Oreste P, Schiantarelli C, Landonio G, Alexiadis S, Gargantini L, Caggese L, Gambacorta M, Morra E (1996) Anaplastic large cell (CD30/Ki-1 + ) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients. Br J Haematol 95:508–512
Oksenhendler E, Duarte M, Soulier J, Cacoub P, Welker Y, Cadranel J, Cazals HD, Autran B, Clauvel JP, Raphael M (1996) Multicentric Castleman’s disease in HIV infection: a clinical and pathological study of 20 patients. AIDS 10:61–67
Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato T, Ota H, Mori S (1995) BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86:28–37
Parravinci C, Corbellino M, Paulli M, Magrini U, Lazzarino M, Moore PS, Chang Y (1997) Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman’s disease. Am J Pathol 151:1517–1522
Pau CP, Lam LL, Spira TJ, Black JB, Stewart JA, Pellett PE, Respess RA (1998) Mapping and sero-diagnostic application of a dominant epitope within the human herpesvirus 8 ORF 65-encoded protein. J Clin Microbiol 36:1574–1577
Pelicci PG, Knowles DMd, Arlin ZA, Wieczorek R, Luciw P, Dina D, Basilico C, Dalla-Favera R (1986) Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis. J Exp Med 164:2049–2060
Rabkin CS, Schulz TF, Whitby D, Lennette ET, Magpantay LI, Chatlynne L, Biggar RJ (1998) Inter-assay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group. J Infect Dis 178:304–309
Regamey N, Cathomas G, Schwager M, Wernli M, Harr T, Erb P (1998) High human herpesvirus 8 seroprevalence in the homosexual population in Switzerland. J Clin Microbiol 36:1784–1786
Renne R, Lagunoff M, Zhong W, Ganem D (1996a) The size and conformation of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol 70:8151–8154
Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D (1996b) Lytic growth of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 2:342–346
Rowe M, Lear AL, Croom-Carter D, Davies AH, Rickinson AB (1992) Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes. J Virol 66:122–131
Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 93:14862–14867
Said JW, Chien K, Tasaka T, Koeffier HP (1997) Ultrastructural characterization of human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus) in Kaposi’s sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (CMV). J Pathol 182:273–281
Shiramizu B, Herndier B, Meeker T, Kaplan L, McGrath M (1992) Molecular and immunophenotypic characterization of AIDS-associated, Epstein-Barr virus-negative, polyclonal lymphoma. J Clin Oncol 10:383–389
Shiramizu B, Herndier BG, McGrath MS (1994) Identification of a common clonal human immunodeficiency virus integration site in human immunodeficiency virus-associated lymphomas. Cancer Res 54:2069–2072
Simpson GR, Schulz TF, Whitby D, Cook PM, BoshofT C, Rainbow L, Howard MR, Gao SJ, Bohenzky RA, Simmonds P, Lee C, de RA, Hatzakis A, Tedder RS, Weller IV, Weiss RA, Moore PS (1996) Prevalence of Kaposi’s sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 348:1133–1138
Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals HD, Babinet P, d’Agay MF, Clauvel JP, Raphael M, Degos L, et al. (1995) Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman’s disease. Blood 86:1276–1280
Subar M, Neri A, Inghirami G, Knowles DM, Dalla-Favera R (1988) Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDS-associated lymphoma. Blood 72:667–671
Tedeschi R, De PP, Schulz TF, Dillner J (1999) Human serum antibodies to a major defined epitope of human Herpesvirus 8 small viral capsid antigen. J Infect Dis 179:1016–1020
Tirelli U, Vaccher E, Zagonel V, Talamini R, Bernardi D, Tavio M, Gloghini A, Merola MC, Monfardini S, Carbone A (1995) CD30 (Ki-l)-positive anaplastic large-cell lymphomas in 13 patients with and 27 patients without human immunodeficiency virus infection: the first comparative clinicopathologic study from a single institution that also includes 80 patients with other human immunodeficiency virus-related systemic lymphomas. J Clin Oncol 13:373–380
Wang D, Liebowitz D, Kieff E (1985) An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43:831–840
Welch K, Finkbeiner W, Alpers CE, Blumenfeld W, Davis RL, Smuckler EA, Beckstead JH (1984) Autopsy findings in the acquired immune deficiency syndrome. JAMA 252:1152–1159
Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, Nakahata T, Kawai H, Tagoh H, Komori T, Kishimoto S, Hirano T, Kishimoto T (1989) Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease. Blood 74:1360–1367
Zheng H, Mori S (1997) Epstein-Barr virus-infected lymphocytes in non-neoplastic lymph nodes of patients infected with human immunodeficiency virus. Pathol Int 47:217–221
Zhu L, Wang R, Sweat A, Goldstein E, Horvat R, Chandran B (1999) Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells. Virology 256:381–392
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Katano, H., Sata, T., Mori, S. (2001). AIDS Lymphoma: Its Virological Aspects. In: Takada, K. (eds) Epstein-Barr Virus and Human Cancer. Current Topics in Microbiology and Immunology, vol 258. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56515-1_8
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