Abstract
To evaluate the prevalence of the clinical findings in Behçet’s disease, we retrospectively analyzed the clinical data of 2147 Behçet patients from 9 to 87 years of age (mean age 38.3 years) followed up during the years 1976 through 1997. One thousand ninety three patients were male and 1054 patients were female. Male/female ratio was 1.03. The mean age at onset was 25.6 years. A family history of Behçet’s disease was present in 7.3% of the patients. Positive pathergy was found in 1220 (56.8%) patients. All of the patients had mucocutaneous lesions. Out of the 2147 patients, the disease manifested itself as only mucocutaneous involvement in 1168 patients. The prevalence of systemic manifestations was found as follows: 28.9% ocular involvement, 16.0% musculoskeletal involvement, 16.8% vascular involvement, 2.8% gastrointestinal involvement and 2.2% neurological involvement. Pulmonary involvement was seen in 20 (1.0%) patients, cardiac involvement was seen in 3 patients and renal involvement was observed in 2 patients. Male patients had vascular involvement 5.02, neurologic involvement 2.21 and ocular involvement 1.98 times more frequently than female patients.
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References
Arbesfeld SI, Kurban AK: Behçet’s disease; New perspectives on an enigmatic syndrome. J Am Acad Dermatol 19: 767–79,1988.
Azizlerli G, Köse AA, Sarica R, Disci R, Çankaya P: The course of the disease in Behçet’s Syndrome. 8th International Congress on Behçet’s Disease. October 7–9, 1998; Reggio Emilia, Italy.
Behçet H: Uber rezidivierende aphthouse durch ein virus verursachte Geschwuere am Mund, am Auge und an den Genitalien. Dermatol Monatsschr Wochenschr 105: 1152–7, 1937.
Benamour S, Bennis R, Amraoui A: A study of 285 cases of Behçet’s disease. In O’Duffy, Kökmen E ed. Behçet’s Disease, Basic and Clinical aspects. New York, Marcel Dekker Inc, 1991, 259–267.
Chamberlain MA: A family study of Behçet’s syndrome. Ann Rheum Dis 37: 459–465, 1978.
Dilsen N, Koniçe M, Aral 0, Deal L, Inanç M et al: Risk factors in vital organ involvement in Behçet’s disease. In Wechsler B, Godeau P, ed. Behçet’s Disease. Amsterdam, Elsevier Science Publishers, 1993, 165–170.
Dilsen N, Koniçe M, Aral 0, Inanç M, Gül A, Deal L et al: Important implications of skin pathergy test in Behçet’s disease. In Wechsler B, Godeau P, ed. Behçet’s Disease. Amsterdam, Elsevier Science Publishers, 1993, 229–233.
Gharibdoost F, Davatchi F, Shahram F, Akbarian M, Chams C, et al: Clinical manifestations of Behçet’s disease in Iran. Analysis of 2176 cases. In Wechsler B, Godeau P, ed. Behçet’s Disease. Amsterdam, Elsevier Science Publishers, 1993, 153–8.
Goolamali SK, Comaish JS, Hassanyeh F, Stephens A: Familial Behçet’s Syndrome. Br J Dermatol 95: 637–642, 1976.
Hamburger I, Whallett AI, Thurairajan G, Murray PI, Palmer RG: Clinical features of 50 patients with Behçet’s disease attending a multidisciplinary clinic. 8th International Congress on Behçet’s Disease. October 7–9, 1998; Reggio Emilia, Italy.
International study group for Behçet’s disease: Criteria for diagnosis of Behçet’s disease. Lancet 335: 1078–80, 1990.
James DG: Behçet’s disease. BJCP 44: 364–8,1990.
Madanat W, Fayyad F, Zureikat H, Verity D, Narr J, Vaughan R, Stanford M: Analysis of 150 cases of Behçet’s disease from Jordan. 8th International Congress on Behçet’s Disease. October 7–9, 1998; Reggio Emilia, Italy.
Mangelsdorf HC, White WL, Jorizzo JL: Behçet’s disease. J Am Acad Dermatol 34: 745–50,1996.
Michelson JB, Friedlaender MH: Behçet’s Disease. Int Ophtalmo I Clin 30: 271–8,1990.
O’Duffy JD: Vasculitis in Behçet’s disease. Rheumatic Disease Clinics of North America 16: 423–431,1990.
Pande I, Uppal SS, Kailash S, Kumar A, Malaviya AN: Behçet’s disease in India: A clinical, immunological, immunogenetic and outcome study. Br J Rheum 34: 825–830,1995.
Prokaeva T, Madanat W, Yermakova N, Alekberova Z: Sex dimophism of Behçet’s disease. In Wechsler B, Godeau P, ed. Behçet’s Disease. Amsterdam, Elsevier Science Publishers, 1993, 219–221.
Shimizu T, Ehrlich GE, Inaba G, et al: Behçet’s disease (Behçet’s syndrome). Sem Arthr Rheumatism 8: 223, 1979.
Steward JA: Genetic analysis of families of patients with Behçet’s syndrome: data incompatible with autosomal recessive inheritance. Ann Rheum Dis 45: 265–268, 1986.
Tüzün Y, Altay M, Yazici H,: Nonspecific skin hyperreactivity in Behçet’s Disease. Haematologica 65: 395–398,1980.
Wong RC, Ellis CN, Diaz LA: Behçet’s disease. Int J Dermatol 23: 25–32,1984.
Yazici H, Tüzün Y, Pazarli H, Yurdakul S, Bzyazgan Y et al: Influence of age of onset and patients sex on the prevalence and severity of manifestations of Behçet’s syndrome. Ann Rheum Dis 43: 783–789, 1984.
Zouboulis Ch. C: Epidemiology of Adamantiades-Behçet’s Disease in Europe. 8th International Congress on Behçet’s Disease. October 7–9, 1998; Reggio Emilia, Italy.
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Gürler, A., Boyvat, A., Türsen, Ü. (2001). Clinical Manifestations of Behçet’s Disease: An Analysis of 2147 Patients. In: Behçet’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56455-0_24
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DOI: https://doi.org/10.1007/978-3-642-56455-0_24
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