Zusammenfassung
Das Mammakarzinom ist der häufigste bösartige Tumor der Frau. Jährlich erkranken in Deutschland etwa 45.000 Frauen neu. Durch die insgesamt steigende Lebenserwartung der Bevölkerung wird eine zunehmende Inzidenz bei älteren Frauen beobachtet. Die Zahl der Frauen im Alter von über 50 Jahren, die pro Jahr an einem Mammakarzinom neu erkranken, ist von 254/100.000 im Jahre 1973 auf 365/100.000 im Jahre 1994 gestiegen. Hingegen blieb die Inzidenz bei den unter 50-jährigen Frauen mit etwa 30/100.000 über die Jahre konstant. Eine 65-jährige Frau hat bereits eine 3-mal höhere Wahrscheinlichkeit, in ihrem nächsten Lebensjahr ein Mammakarzinom zu entwickeln, als eine 45-jährige. Wie die Inzidenz steigt auch die Mortalität mit zunehmendem Alter an. Die altersabhängige Mortalitätsrate für über 60-jährige Frauen ist in Tabelle 28.1 wiedergegeben.
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Literatur
Anonymus (1998a) Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group [see comments]. Lancet 351(9114): 1451–1467
Anonymus (1998b) Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group [see comments]. Lancet 352(9132): 930–942
Bates T et al. (1991) Breast cancer in elderly women: a cancer research campaign trial comparing treatment with tamoxifen and optimal surgery with tamoxifen alone. The Elderly Breast Cancer Working Party. Br J Surg 78(5): 591–594
Christman K et al. (1992) Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience [see comment]. Jama 268(1): 57–62
Colditz GA et al. (1995) The use of estrogens and progestins and the risk of breast cancer in postmenopausal women (see comments). N Engl J Med 332(24): 1589–1593
Daidone MG et al. (1998) Biological characteristics of primary breast cancer in the elderly. In: Balducci L, Lyman GH, Ershler WB(eds) Comprehensive geriatric oncology. Harwood Academic Publishers, Amsterdam, pp 197–200
Dhodapkar MV et al. (1996) Prognostic factors in elderly women with metastatic breast cancer treated with tamoxifen: an analysis of patients entered on four prospective clinical trials. Cancer 77(4): 683–690
Diel IJ et al. (1998) Reduction in new metastases in breast cancer with adjuvant clodronate treatment (see comments). N Engl J Med 339(6): 357–363
Faulk RM et al. (1995) Clinical efficacy of mammographic screening in the elderly. Radiology 194 (1): 193–197
Fisher B et al. (1998) Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study (see comments). J Natl Cancer Inst 90(18): 1371–1388
Forrest AP et al. (1996) Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Scottish Cancer Trials Breast Group (see comments). Lancet 348(9029): 708–713
Greenfield S et al. (1987) Patterns of care related to age of breast cancer patients. Jama 257(20): 2766–2770
Hutchins LF et al. (1999) Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341(27): 2061–2067
Kaufmann M et al. (2001) Aktuelle Empfehlungen zur Therapie primärer Mammakarzinome. Dtsch Ärztebl 98: B 1839–1841
Kerlikowske K et al. (1995) Efficacy of screening mammography. A meta-analysis (see comments). Jama 273(2): 149–154
Newschaffer CJ et al. (1996) The effect of age and comorbidity in the treatment of elderly women with nonmetastatic breast cancer. Arch Intern Med 156(1): 85–90
Nixon AJ et al. (1994) Relationship of patient age to pathologic features ot the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol 12(5): 888–894
Peyrade F et al. (1996) Age-related difference in tamoxifen disposition. Clin Parmacol Ther 59(4): 401–410
Satariano WA, Ragland DR (1994) The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med 120(2): 104–110
Taylor SG et al. (1986) Combination chemotherapy compared to tamoxifen as initial therapy for stage IV breast cancer in elderly women. Ann Intern Med 104(4): 455–461
Van Zee KJ et al. (1999) Long term follow-up of women with ductal carcinoma in situ treated with breast-conserving surgery: the effect of age. Cancer 1986(9): 1757–1767
Veronesi U et al. (1993) Radiotherapy after breast-preserving surgery in women with localized cancer of the breast (see comments). New Engl J Med 328(22): 1587–1591
Veronesi U et al. (1997) Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes (see comments). Lancet 349(9069): 1864–1867
Wanebo HJ et al. (1997) Is surgical management compromised in elderly patients with breast cancer? Ann Surg 225(5): 579–586; discussion 586-589
Yancik R, Ries LG, Yates JW (1989) Breast cancer in aging women. A population-based study of contrasts in stage, surgery and survival. Cancer 63(5): 976–981
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Volm, T., Wedding, U., Dunst, J., Kreienberg, R., Höffken, K. (2002). Mammakarzinom. In: Höffken, K., Wedding, U., Kolb, G. (eds) Geriatrische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56391-1_28
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