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Experimentelle Studien zur Teratogenität von Valproinsäure

  • M. Radatz
  • Heinz Nau

Zusammenfassung

Epidemiologische Studien belegen das erhöhte Missbildungsrisiko durch Valproinsäureeinnahme während der Schwangerschaft. Der teratogene Effekt ist dosisabhängig und von hoher Strukturspezifität. Untersuchungen am Tiermodell weisen auf einen chiralen rezeptor-ähnlichen Wirkungsort im Embryo. Valproinsäure interagiert mit bekannten Transkriptionsfaktoren und anderen Zielgenen während der Neuralrohrentwicklung. Der teratogene Mechanismus ist noch nicht aufgeklärt.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • M. Radatz
  • Heinz Nau

There are no affiliations available

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