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Valproinsäure pp 381–391Cite as

Einfluss von Valproinsäure auf Fettstoffwechsel und Carnitin

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Literatur

  • Alonso E, Girbés J, Garcia-Espano A, Rubio V (1989) Changes in urea cycle-related metabolites in the mouse after combined administration of valproic acid and an amino acid load. Arch Biochem Biophys 272:267–273

    Article  PubMed  CAS  Google Scholar 

  • Becker C-M, Harris RA (1983) Influence of valproid acid on hepatic carbohydrate and lipid metabolism. Arch Biochem Biophys 223:381–392

    Article  PubMed  CAS  Google Scholar 

  • Bolanos JP, Medina JM, Williamson DH (1990) Inhibition of sterol but not fatty acid synthesis by valproate in developing rat brain in vivo. Biochem J 272:251–253

    PubMed  CAS  Google Scholar 

  • Beghi E, Bizzi A, Codegoni AM, Trevisan D, Torri W (1990) Valproate, carnitine metabolism and biochemical indicators of liver function. Epilepsia 31:346–352

    Article  PubMed  CAS  Google Scholar 

  • Böhles, H, Richter K, Wagner-Thiessen E, Schäfer H (1982) Decreased serum carnitine in valproate induced Reye syndrome. Eur J Pediatr 139:185–186

    Article  PubMed  Google Scholar 

  • Bjorge SM, Baillie TA (1985) Inhibition of medium L chain fatty acid (13-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid. Biochem Biophys Res Commun 132:245–252

    Article  PubMed  CAS  Google Scholar 

  • Camina MF, Rozas J, Castro-Gago M, Paz JM, Alonso C, Rodriguez-Segade S (1991) Alteration of renal carnitine metabolism by anticonvulsant treatment. Neurology 41:1444–1448

    Article  PubMed  CAS  Google Scholar 

  • Camina MF, Rozas J, Gómez M, Paz JM, Alonso C, Rodriguez-Segade S (1991) Short-term effects of administration of anticonvulsant drugs on free carnitine and acylcarnitine in mouse scrum and tissues. Br J Pharmacol 103:1179–1183

    Article  PubMed  CAS  Google Scholar 

  • Costell M, O’Connor J-E, Niguez M-P, Grisolla S (1984) Effects of L-carnitine on urea synthesis following acute ammonia intoxication in mice. Biochem Biophys Res Commun 120:726–733

    Article  PubMed  CAS  Google Scholar 

  • Coudé FX, Grimber F, Pelet A, Benoit Y (1983) Action of the antiepileptic drug, valproic acid, on fatty acid oxidation in isolated rat hepatocytes. Biochem Biophys Res Commun 115: 730–736

    Article  PubMed  Google Scholar 

  • Coulter DL (1984) Carnitine deficiency: A possible mechanism for valproate hepatotoxicity (letter). Lancet 1:689

    Article  PubMed  CAS  Google Scholar 

  • Dickinson RG, Hooper WD, Dunstan PR, Eadie MJ (1989) Urinary excretion of valproate and some metabolites in chronically treated patients. Therap Drug Monit 11:127–133

    Article  CAS  Google Scholar 

  • Di Donato S, Rimoldi M, Garavaglia B, Uziel G (1984) Propionylcarnitine excretion in propionic and methylmalonic acidurias: A cause of carnitine deficiency. Clin Chim Acta 139:13–21

    Article  PubMed  Google Scholar 

  • Draye J-P, Vamecq J (1987) The inhibition by valproic acid of the mitchondrial oxidation of monocarboxylic and (co-hydroxylmonocarboxylic acids: Possible implications for the metabolism of (y-aminobutyric acid. J Biochem 102:235–242

    PubMed  CAS  Google Scholar 

  • Dreifuss F, Langer DH (1987) Hepatic considerations in the use of antiepileptic drugs. Epilcpsia 28 (Suppl):S23–S29

    Article  Google Scholar 

  • Grannemann GR, Wang S-J, Kesterson JW, Machinist JM (1984) The hepatotoxicity of valproic acid and its metabolites in rats. II. Intermediary and valproic acid metabolism. Hepatology 4:1153–1156

    Article  Google Scholar 

  • Hayasaka K, Takahashi J, Kobayashi Y, Junuma K, Narisawa K, Tada K (1986) Effects of valproate on biogenesis and function of liver mitochondria. Neurology 36:351–356

    Article  PubMed  CAS  Google Scholar 

  • Horic S, Suga T (1985) Enhancement of peroxisomal (p-oxidation in the liver of rats and mice treated with valproic acid. Biochem Pharmacol 34:1357–1362

    Article  Google Scholar 

  • Kesterson JW, Grannemann GR, Machinist JM (1984) The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies. Hepatology 4: 1143–1152

    Article  PubMed  CAS  Google Scholar 

  • Kingsley E, Gray P, Tolman KG, Tweedale R (1983) The toxicity of metabolites of sodium valproate in cultured hepatocytes. J Clin Pharmacol 23:178–185

    PubMed  CAS  Google Scholar 

  • König S, Scheffner D, Rauterberg-Ruland J, Kochen W, Hofmann WJ, Wokittel E, Schick U (1983) Tödliches Leberversagen bei einem altersgemäß entwickelten fünf Jahre alten Jungen unter VPA-Monotherapie. Monatsschr Kinderheilk 135:310–313

    Google Scholar 

  • Laub MC, Paetzke-Brunner J, Jäger G (1986) Serum carnitine during valproic acid therapy. Epilepsia 27:559–562

    Article  PubMed  CAS  Google Scholar 

  • Laub MC (1988) Ist eine Carnitinsubstitution bei Valproattherapie sinnvoll? Epilepsie-Blatter 1:31–35

    Google Scholar 

  • Lin MH, Acheampong AA, Russell RG, Levy RH (1990) Effect of L-carnitine on hepatotoxicity and inhibition of fatty acid metabolism with valproate and (4-valproate (abstract). Epilepsia 31:600

    Google Scholar 

  • Matsuda J, Ohtani Y, Ninomiya N (1986) Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy. J Pediatr 109:131–134

    Article  PubMed  CAS  Google Scholar 

  • Melegh B, Körner J, Kispél G, Acsádi G, Dani M (1987) Effect of chronic valproic acid treatment on plasma and urine carnitine levels in children: Decreased urinary excretion. Acta Paediatrica Hungarica 28:137–142

    PubMed  CAS  Google Scholar 

  • Melegh B, Kerner J, Jaszar V, Bieber LL (1990a) Differential excretion of xenobiotic acyl-esters of carnitine due to administration of pivampicillin and valproate. Biochem Med Metab Biol 43:30–38

    Article  PubMed  CAS  Google Scholar 

  • Melegh B, Kerner J, Ascádi G, Lakatos J, Sándor A (1990b) L-carnitine replacement therapy in chronic valproate treatment. Neuropediatrics 21:40–43

    Article  PubMed  CAS  Google Scholar 

  • Moore KH, Decker BP, Schreefel FP (1988) Hepatic hydrolysis of octanoyl-CoA and valproyl-CoA in control and valproate-fed animals. Int J Biochem 20:175–178

    Article  PubMed  CAS  Google Scholar 

  • Morita J, Yuge K, Yoshino M (1986) Hypocarnitinemia in the handicapped individuals who receive a polypharmacy of antiepileptic drugs. Neuropediatrics 17:203–205

    Article  PubMed  CAS  Google Scholar 

  • Mortensen PB, Gregersen N, Kolvraa S, Christensen E (1980) The occurrence of C6-C0-dicarboxylic acids in urine from patients and rats treated with dipropylacetate. Biochem Med 24:153–161

    Article  PubMed  CAS  Google Scholar 

  • Murakami K, Sugimoto T, Nishida N, Woo M, Araki A, Kobayashi Y, Sakane Y (1990) Carnitine metabolism and morphometric change of liver mitochondria in valproate-treated rats. Neuropediatrics 21:187–190

    Article  PubMed  CAS  Google Scholar 

  • Murphy JV, Marquardt KM, Shug AL (1985) Valproic acid associated with abnormalities of carnitine metabolism (letter). Lancet 1:820–821

    Article  PubMed  CAS  Google Scholar 

  • Nishida N, Sugimoto T, Araki A, Woo M, Sakane Y, Kobayashi Y (1987) Carnitine metabolism in valproate-treated rats: The effect of L-carnitine supplementation. Pediatr Res 22:500–503

    Article  PubMed  CAS  Google Scholar 

  • Ohtani YF, Endo I, Matsuda I (1982) Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J Pediatr 101:782–785

    Article  PubMed  CAS  Google Scholar 

  • Olson MJ, Handler JA, Thurman RG (1986) Mechanism of zone-specific hepatic steatosis caused by valproate: Inhibition of ketogenesis in periportal regions of the liver lobule. Molec Pharmacol 30:520–525

    CAS  Google Scholar 

  • Opala G, Winter S, Vance C, Vance H, Hutchinson HT, Linn LS (1991) The effect of valproic acid on plasma carnitine levels. Amer J Dis Childh 145:999–1001

    CAS  Google Scholar 

  • Ponchaut S, Draye JP, Veitch K, Van Hoof F (1991) Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Biochem Pharmacol 41:1419–1428

    Article  PubMed  CAS  Google Scholar 

  • Powell-Jackson PR, Tredger JM, Williams R (1984) Hepatotoxicity to sodium valproate: A review. Gut 25:673–681

    Article  PubMed  CAS  Google Scholar 

  • Quistad GB, Staiger LE, Schooley DA (1986) The role of carnitine in the conjugation of acidic xenobiotics. Drug Metab Disposition 14:521–525

    CAS  Google Scholar 

  • Rebouche CJ, Engel AG (1983) Carnitine metabolism and deficiency syndromes. Mayo Clin Proc 58:533–540

    PubMed  CAS  Google Scholar 

  • Rebouche CJ, Poulson DJ (1986) Carnitine metabolism and functions in humans. Ann Rev Nutr 6:41–66

    Article  CAS  Google Scholar 

  • Rodriguez-Segade S, de la Pena A, Tutor JC, Paz JM, Fernandez MP, Rozas J, Del Rio R (1989) Carnitine deficiency associated with anticonvulsant therapy. Clin Chim Acta 1981:175–182

    Article  Google Scholar 

  • Rozas J, Camina MF, Paz JM, Alonso C, Castro-Gago M, Rodriguez-Segade S (1989) Effects of acutevalproate administration on carnitine metabolism in mouse serum and tissues. Biochem Pharmacol 39:181–185

    Article  Google Scholar 

  • Schmidt-Sommerfeld E, Penn D (1986) 123456 Carnitinmangel. Monatschr Kinderheilk 134:224–231

    CAS  Google Scholar 

  • Shumate JB, Dodson WE, Brooke MH, Santiago J (1981) Suppression of fatty acid oxidation by valproic acid (abstract). Ann Neurol 10:88

    Google Scholar 

  • Singh Y, Lin GA, Krishna G (1987) Valproic acid-induced increase in acetyltransferase in rat hepatocytes is not due to an induction of peroxisomes. J Toxicol Environ Health 22:459–469

    Article  PubMed  CAS  Google Scholar 

  • Suchy FJ, Ballistreri WP, Buchino JJ, Sondheimer JM, Bates SR, Kearns GL, Stull JD, Bove KE (1979) Acute hepatic failure associated with the use of sodium valproate. Report of two fatal cases. New Engl J Med 300:962–966

    Article  PubMed  CAS  Google Scholar 

  • Stiemer B (1989) Morphological evaluation of steatosis in monolayer cultures (MDCK cells) after treatment with gentamicin and valproic acid. Histol Histopath 4:421–428

    CAS  Google Scholar 

  • Sugimoto T, Woo M, Nishida N, Takeuchi T, Sakane Y, Kobayashi Y (1987a) Hepatotoxicity in rat following administration of valproic acid. Epilepsia 28:142–146

    Article  PubMed  CAS  Google Scholar 

  • Sugimoto T,Araki A, Nishida N, Sakane Y, Woo M, Takeuchi T, Kobayashi Y (1987b) Hepatotoxicity in rat following administration of valproic acid: Effect of L-carnitine supplementation. Epilepsia 28:373–377

    Article  PubMed  CAS  Google Scholar 

  • Takeuchi T, Sugimoto T, Nishida N, Kobayashi Y (1988a) Evaluation of the cytotoxicity of sodium valproate on primary cultured rat hepatocytes. Neuropediatrics 19:158–161

    Article  PubMed  CAS  Google Scholar 

  • Takeuchi T, Sugimoto T, Nishida N, Kobayashi Y (1988b) Protective effect of D, L-carnitine on valproate-induced hyperammonemia and hypoketonemia in primary cultured rat hepatocytes. Biochem Pharmacol 37:2255–2258

    Article  PubMed  CAS  Google Scholar 

  • Thom H, Carter PE, Cole GF, Stevenson KL (1991) Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs. Developm Med Child Neurol 33:795–802

    Article  CAS  Google Scholar 

  • Thurston JH, Carroll JE, Dodson WE, Hauhart RE, Tasch V (1983) Chronic valproate administration reduces fasting ketonemia in children. Neurology 33:1348–1350

    Article  PubMed  CAS  Google Scholar 

  • Thurston JH, Carroll JE, Hauhart RE, Schiro JA (1985) A single therapeutic dose of valproate affects liver carbohydrate, tat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: possible clinical significance. Life Sci 36:1643–1651

    Article  PubMed  CAS  Google Scholar 

  • Thygesen J, Boesen P (1982) 2 cases of reversible liver lesion induced by valproate. Acta Neurol Scand 60:396–399

    Google Scholar 

  • Turnbull DM, Bone AJ, Bartlett K, Koundakjian PP, Sherratt HSA (1983) The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats. Biochem Pharmacol 32:1887–1892

    Article  PubMed  CAS  Google Scholar 

  • Van den Branden C, Roels F (1985) Peroxisomal (ß-oxidation and sodium valproate. Biochem Pharmacol 34:2147–2149

    Article  PubMed  Google Scholar 

  • Ware S, Millward-Sadler GH (1989) Acute liver disease associated with sodium valproate. Lancet 11:1110–1113

    Google Scholar 

  • Winter SC, Szabo-Aczel S, Curry CJR, Hutchinson HT, Hogne R, Shug A (1987) Plasma carnitine deficiency. Clinical observations in 51 pediatric patients. Amer J Dis Childh 41:660–665

    Google Scholar 

  • Young RSK, Bergman I, Gang DL, Richardson EP (1980) Fatal Reye-like syndrome associated with valproic acid. Ann Neurol 7:389

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann HJ, Ishak KG (1982) Valproate-induced hepatic injury: Analysis of 23 fatal cases. Hepatology 2:591–597

    Article  Google Scholar 

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Authors
  1. M. C. Laub
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Editors and Affiliations

  1. Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, Zürich, 8008, Schweiz

    Günter Krämer

  2. Abt. Psychiatrie und Psychotherapie, Klinikum der Albert-Ludwig-Universität, Hauptstr. 5, Freiburg, 79104, Destschland

    Jörg Walden

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Laub, M.C. (2002). Einfluss von Valproinsäure auf Fettstoffwechsel und Carnitin. In: Krämer, G., Walden, J. (eds) Valproinsäure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56329-4_36

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  • DOI: https://doi.org/10.1007/978-3-642-56329-4_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63068-2

  • Online ISBN: 978-3-642-56329-4

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