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Valproinsäure pp 330-341 | Cite as

Kognitive Nebenwirkungen von Valproinsäure

  • A. P. Aldenkamp

Zusammenfassung

Valproinsäure (valproic acid, VPA) ist momentan weltweit eines der am meisten angewendeten Antiepileptika. Es hat einen unbestrittenen Platz in der Erstbehandlungstherapie erworben mit einem günstigen Profil in der klinischen Praxis. Die Analyse der verfügbaren Studien weist darauf hin, dass VPA eine psychomotorische Verlangsamung milder Art verursachen kann. Dosierung und Formulierung haben keinen besonderen Effekt auf kognitive Funktionen, und es besteht kein Zusammenhang zwischen kognitiven Nebenwirkungen von VPA und der Höhe der Serumkonzentration. Überraschenderweise gibt es nur wenige zuverlässige empirische Studien, in denen die Effekte von VPA mit denen von anderen Antiepileptika verglichen werden.

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© Springer-Verlag Berlin Heidelberg 2002

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  • A. P. Aldenkamp

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