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Wirkungsmechanismus von Valproinsäure: Neurophysiologische Aspekte

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Valproinsäure

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Zusammenfassung

Valproinsäure (valproic acid, VPA)besitzt in den von uns untersuchten In-vitroEpilepsiemodellen von allen klinisch verwendeten Antikonvulsiva das relativ weiteste Wirkspektrum. VPA beeinflusst die Erregungsbildung an Nervenzellen sowohl über eine nutzungsabhängige Blockade von Natriumströmen wie durch eine Blockade der T-Kalziumströme. Darüber hinaus steigert VPA die Synthese von GABA und reduziert die Bildung von Aspartat. Damit ist VPA ähnlich wie die meisten anderen klinisch verwendeten anfallsunterdrückenden Substanzen keine sehr spezifisch wirkende Substanz. Die nachgewiesenen Wirkungen von VPA sind aber vereinbar mit dem breiten Wirkspektrum von VPA.

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Authors
  1. U. Heinemann
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  2. J. Dreier
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  3. J. Stabel
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  4. C. L. Zhang
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  5. A. Leschinger
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  6. E. Ficker
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Editor information

Editors and Affiliations

  1. Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, Zürich, 8008, Schweiz

    Günter Krämer

  2. Abt. Psychiatrie und Psychotherapie, Klinikum der Albert-Ludwig-Universität, Hauptstr. 5, Freiburg, 79104, Destschland

    Jörg Walden

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© 2002 Springer-Verlag Berlin Heidelberg

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Heinemann, U., Dreier, J., Stabel, J., Zhang, C.L., Leschinger, A., Ficker, E. (2002). Wirkungsmechanismus von Valproinsäure: Neurophysiologische Aspekte. In: Krämer, G., Walden, J. (eds) Valproinsäure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56329-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-56329-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63068-2

  • Online ISBN: 978-3-642-56329-4

  • eBook Packages: Springer Book Archive

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