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Valproinsäure pp 230-239 | Cite as

Verhalten und Leistungsfähigkeit unter Valproinsäure

  • R. Blank

Zusammenfassung

Unter Berücksichtigung der vielfältigen Einflussfaktoren auf psychische Funktionen und z.T. aufgrund dessen methodisch häufig unzureichender Studien kann subsumiert werden, dass Valproinsäure (valproic acid, VPA) langfristig kaum ungünstige, z.T. sogar relativ günstige Wirkungen hat. Im einzelnen zeigt sich hinsichtlich der Wirkungen auf Leistungsfunktionen, dass kurzfristig mit einer leichten Beeinträchtigung von kognitiven und psychomotorischen Funktionen zu rechnen ist. Im Vergleich zu anderen Antiepileptika schneidet VPA aber günstig ab. So finden sich ähnlich geringe, z.T. sogar positive Wirkungen wie bei Carbamazepin auf Leistungsfunktionen; VPA erscheint eindeutig günstiger im Vergleich zu den Barbituraten und partiell günstiger im Vergleich zu Phenytoin.

Zur Auswirkung von VPA auf die klinische Psychopathologie und das Sozialverhalten sind bisher kaum systematische Studien unternommen worden. Eher kasuistisch wird eine Verbesserung der Affektlabilität und der sozialen Anpassung, vor allem im Vergleich zu den Barbituraten, beschrieben.

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© Springer-Verlag Berlin Heidelberg 2002

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  • R. Blank

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