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Valproinsäure pp 121-129 | Cite as

EEG-Veränderungen unter Valproinsäure

  • R. Besser

Zusammenfassung

Die auffälligsten EEG-Veränderungen durch Valproinsäure (valproic acid, VPA) bestehen in einer Reduktion krankheitstypischer generalisierter und fokaler Spikewave-Paroxysmen bei idiopathischen Epilepsien, wohingegen fokale Paroxysmen von symptomatischen und kryptogenen Epilepsien unbeeinflusst bleiben. Der Einfluss auf die Grundaktivität des EEG durch VPA ist nur diskret ausgeprägt. Zu Beginn einer Behandlung kann es zu einer Zunahme langsamer Aktivität kommen, die möglicherweise im Zusammenhang mit einer asymptomatischen Ammoniakerhöhung steht. Im übrigen scheint die 13-Aktivität abzunehmen. Ausgeprägte EEG-Verlangsamungen finden sich bei klinisch manifesten metabolischen VPA-Enzephalopathien und bei VPA-Intoxikationen, ohne dass dies substanzspezifisch wäre. Eine generalisierte Amplitudendepression entwickelt sich bei einem begleitenden diffusen Hirnödem. Das Schlaf-EEG wird durch VPA weder bei Gesunden noch bei Epilepsiepatienten richtungsweisend verändert.

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© Springer-Verlag Berlin Heidelberg 2002

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  • R. Besser

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