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Purpuriforme und hämorrhagische Krankheitsbilder der Haut

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Therapie der Hautkrankheiten

Zusammenfassung

Blutaustritte aus dem Gefäßnetz der Haut können morphologisch unterschiedlich aussehen: In vielen Fällen stellen sie sich in Form stecknadelkopfgroßer Punktblutungen aus den oberflächlichen Kapillaren des Stratum papilläre dar, die als „Purpura” im engeren Sinne aufzufassen sind; zum anderen treten sie als größere Hautblutungen, d.h. als Hämorrhagien und Suffusionen, aus dem tief gelegenen korialen Gefäßplexus auf. Vielfach entsteht an der Haut ein buntes Bild, das entweder auf eine spezifische Dermatose oder aber auf eine allgemeine hämorrhagische Diathese hinweisen und damit diagnostische Bedeutung haben kann, z.B. zur Erkennung einer hämatologischen Erkrankung (Abb. 28.1).

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Literatur zu Kapitel 28

  • Allen NB, Bressler PB (1997) Diagnosis and treatment of the systemic and cutaneous necrotizing vasculitis syndromes. Med Clin North Am 81: 243–259

    Article  PubMed  CAS  Google Scholar 

  • Andressen JC (1994) Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. N Engl J Med 330:1560–1564

    Article  Google Scholar 

  • Auletta MJ, Headington JT (1988) Purpura fulminans. A cutaneous manifestation of severe protein C deficiency. Arch Dermatol 124:1387–1391

    Article  PubMed  CAS  Google Scholar 

  • Barrios NJ, Humbert JR, McNeil J (1993) Treatment of acute idiopathic thrombocytopenic purpura with high-dose methylprednisolone and Immunglobulin. Acta Haematol 89: 6–9

    Article  PubMed  CAS  Google Scholar 

  • Ben-Yehuda D, Gillis S, Eldor A (1994) Clinical and therapeutic experience in 712 Israeli patients with idiopathic thrombocytopenic purpura. Acta Haematol 91:1–6

    Article  PubMed  CAS  Google Scholar 

  • Berchtold P (1993) Kostenbewußtes Vorgehen bei der Behandlung der autoimmunthrombozytopenischen Purpura. Ther Umsch 50: 88–93

    PubMed  CAS  Google Scholar 

  • Blanchette VS, Kirby MA, Turner C (1992) Role of intravenous Immunglobulin G in autoimmune hematologic disorders. Semin Hematol 29 [Suppl]: 72–82

    PubMed  CAS  Google Scholar 

  • Blanchette V, Freedman J, Garvey B (1998) Management of chronic immune thrombocytopenic purpura in children and adults. Semin Hematol 35:36–51

    PubMed  CAS  Google Scholar 

  • Blanco R, Martinez-Taboada VM, Rodriguez-Valverde V, Garcia-Fuentes M (1998) Cutaneous vasculitis in children and adults. Associated diseases and etiologic factors in 303 patients. Medicine (Baltimore) 77:403–418

    Article  CAS  Google Scholar 

  • Clouse LH, Comp PC (1986) The regulation of hemostasis: the protein C system. N Engl J Med 314:1298–1304

    Article  PubMed  CAS  Google Scholar 

  • Collins PW, Newland AC (1992) Treatment modalities of autoimmune blood disorders. Semin Hematol 29: 64–74

    PubMed  CAS  Google Scholar 

  • D’Angelo A, Vigano-D’Angelo S, Esmon CT, Comp PC (1988) Acquired deficiencies of protein S.J Clin Invest 81:1445–1454

    Article  PubMed  Google Scholar 

  • Dickerhoff R, Ruecker A von (2000) The clinical course of immune thrombocytopenic purpura in children who did not receive intravenous immunoglobulins or sustained prednisone treatment. J Pediatr 137: 629–632

    Article  PubMed  CAS  Google Scholar 

  • Diem E (1989) Pathogenese und Therapie der Heparin-Nekrose. Hautarzt 40: 239

    PubMed  CAS  Google Scholar 

  • Dragoni F, Arcieri R, Chistolini A, De Sanctis V, Pasqualetti D, Mazzucconi MG (1993) Splenectomy outcome in a hemophilic patient with HIV-related immunethrombocytopenia. Haematologica 78: 61–63

    PubMed  CAS  Google Scholar 

  • Falanga V, Bontempo FA, Eaglstein WH (1990) Protein C and Protein S plasma levels in patients with lipodermatosclerosis and venous ulceration. Arch Dermatol 126: 1195–1197

    Article  PubMed  CAS  Google Scholar 

  • Feldmann R, Harms M (1991) Die Bedeutung des Protein-C-Mangels in der Dermatologie. Hautarzt 42: 607–612

    PubMed  CAS  Google Scholar 

  • Figueroa M, Gehlsen J, Hammond D et al. (1993) Combination chemotherapy in refractory immune thrombocytopenic purpura. N Engl J Med 328:1226–1229

    Article  PubMed  CAS  Google Scholar 

  • Frey BM,Fopp M (1993) Therapeutische Plasmapherese eine kritische Würdigung unter Berücksichtigung der aktuellen Literatur. Schweiz Med Wochenschr 123:1725–1735

    PubMed  CAS  Google Scholar 

  • Garcia-Erce JA, Vella JC (1999) Splenectomy and idiopathic thrombocytopenic purpura. Haematologica 84: E04

    Google Scholar 

  • Geiss-Holtorff R, Hafner G, Prellwitz W (1993) Zur Thromboseprophylaxe bei Protein-C-Mangel. Monatsschr Kinderheilkd 141:478–480

    PubMed  CAS  Google Scholar 

  • Gibson LE, Su WP (1995) Cutaneous vasculitis. Rheum Dis Clin North Am 21:1097–1113

    PubMed  CAS  Google Scholar 

  • Gunsilius E, Seifried E (1993) Therapie der Autoim-munthrombozytopenie des Erwachsenen. Infusionsther Transfusionsmed 20 [Suppl 1]: 87–98

    PubMed  Google Scholar 

  • Hord JD, Grossman NJ (1993) Intravenous corticosteroids versus intravenous gammaglobulin in the treatment of acute immune thrombocytopenic purpura. Pediatr Hematol Oncol 10:323–327

    Article  PubMed  CAS  Google Scholar 

  • Israels SJ, Seshia SS (1987) Childhood stroke associated with protein C or S deficiency. J Pediatr 111:562–564

    Article  PubMed  CAS  Google Scholar 

  • Jager D, Huppe D, Weber A et al. (1994) Pfortaderthrombose bei Protein-C-Mangel: Erfolgreiche Fibrinolysetherapie mittels ultrahochdosierter Streptokinase. Med Klin 89: 453–455

    CAS  Google Scholar 

  • Knees U, Macdonald E, Stiegler H et al. (1993) Beckenvenenthrombose bei Protein-C-Mangel nach infektioser Mononukleose. Monatschr Kinderheilkd 141:928–931

    CAS  Google Scholar 

  • Korsten S, Reis HE (1992) Erworbener Protein-C-Mangel bei Colitis ulcerosa. Ursache thromboembolischer Komplikationen. Dtsch Med Wochenschr 117: 419–424

    Article  PubMed  CAS  Google Scholar 

  • Krizsa J, Hunyadi J, Dobozy A (1992) PUVA treatment of pigmented purpuric lichenoid dermatitis (Gougerot-Blum). J Am Acad Dermatol 27: 778–780

    Article  PubMed  CAS  Google Scholar 

  • Lazareth I (1989) La protèine C en dermatologie. Ann Dermatol Vénéréol 116:591–593

    PubMed  CAS  Google Scholar 

  • Lilleyman JS (1999) Management of childhood idiopathic thrombocytopenic purpura. Br J Haematol 105: 871–875

    Article  PubMed  CAS  Google Scholar 

  • Lotti T, Ghersetich I, Comacchi C, Jorizzo JL (1998) Cutaneous small-vessel vasculitis. J Am Acad Dermatol 39: 667–687

    Article  PubMed  CAS  Google Scholar 

  • Lotti TM, Comacchi C, Ghersetich I (1999) Cutaneous necrotizing vasculitis. Relation to systemic disease. Adv Exp Med Biol 455:115–125

    Article  PubMed  CAS  Google Scholar 

  • Marlar RA, Endres Brooks J, Miller C (1985) Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation. Blood 66:59–63

    PubMed  CAS  Google Scholar 

  • McVerry BA (1985) Management of idiopathic thrombocytopenic purpura in adults. Br J Haematol 59: 203–208

    Article  PubMed  CAS  Google Scholar 

  • Moreb J, Kitchens CS (1989) Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: report of two cases. Am J Med 87: 207–210

    Article  PubMed  CAS  Google Scholar 

  • Nydegger U (1994) Alte und neue Aspekte der intravenösen Immunglobulintherapie. Schweiz Med Wochenschr 124: 5–25

    PubMed  CAS  Google Scholar 

  • Powars DR, Rogers ZR, Patch MJ et al. (1987) Purpura fulminans in meningococcemia: Associaton with acquired deficiencies of protein C and S. N Engl J Med 317:571–572

    Article  PubMed  CAS  Google Scholar 

  • Reinhold U, Seiter S, Ugurel S, Tilgen W (1999) Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 41: 207–208

    Article  PubMed  CAS  Google Scholar 

  • Rock GA (2000) Management of thrombotic thrombocytopenic purpura. Br J Haematol 109:496–507

    Article  PubMed  CAS  Google Scholar 

  • Rock G, Porta C, Bobbio-Pallavicini E (2000) Thrombotic thrombocytopenic purpura treatment in year 2000. Haematologica 85:410–419

    PubMed  CAS  Google Scholar 

  • Rongioletti F, Pisani S, Ciaccio M, Rebora A (1989) Skin necrosis due to intravenous Heparin. Dermatologica 178: 47–50

    Article  PubMed  CAS  Google Scholar 

  • Rose M, Rowe JM, Eldor A (1993) The changing course of thrombotic thrombocytopenic purpura and modern therapy. Blood Rev 7:94–103

    Article  PubMed  CAS  Google Scholar 

  • Smith JGJ (1995) Vasculitis. J Dermatol 22: 812–822

    PubMed  Google Scholar 

  • Stadler R, Ruszczak Z (1995) Therapeutic guidelines in vasculitis. Int Angiol 14:188–196

    PubMed  CAS  Google Scholar 

  • Tamaki K, Yasaka N, Osada A, Shibagaki N, Furue M (1995) Successful treatment of pigmented purpuric dermatosis with griseofulvin. Br J Dermatol 132:159–160

    Article  PubMed  CAS  Google Scholar 

  • Teepe RGC, Broekmans AW, Vermeer BJ et al. (1986) Recurrent coumarin-induced skin necrosis in a patient with an acquired functional protein C deficiency. Arch Dermatol 122:1408–1412

    Article  PubMed  CAS  Google Scholar 

  • Tohda S, Ohkusa T (2000) Resolution of refractory idiopathic thrombocytopenic purpura after eradication of helicobacter pylori. Am I Hematol 65:329–330

    Article  CAS  Google Scholar 

  • Tromm A, Huppe D, May B (1992) Protein-C-Mangel bei Colitis ulcerosa. Dtsch Med Wochenschr 117:1130–1131

    PubMed  CAS  Google Scholar 

  • Tsankov N, Angelova I, Kazandjieva J (1999) Topical modalities for the treatment of cutaneous vasculitis. Clin Dermatol 17: 649–653

    Article  PubMed  CAS  Google Scholar 

  • Vogel JJ, Moerloose PA de, Bounameaux H (1989) Protein-C deficiency and pregnancy: a case report. Obstet Gynecol 73:455–456

    PubMed  CAS  Google Scholar 

  • Witt I (1993) Venenthrombosen und hereditärer Protein-C-Mangel. Dtsch Med Wochenschr 118:766–767

    PubMed  CAS  Google Scholar 

  • Zouboulis CC, Gollnick H, Weber S, Peter HH, Orfanos CE (1991) Intravascular coagulation necrosis of the skin associated with cryofibrinogenemia, diabetes mellitus, and cardiolipin autoantibodies. J Am Acad Dermatol 25: 882–888

    Article  PubMed  CAS  Google Scholar 

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U. Blume-Peytavi C. C. Geilen S. Goerdt H. Gollnick E. Haneke F.-M. Köhn B. Tebbe R. Treudler Ch. C. Zouboulis

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Orfanos, C.E., Garbe, C. (2002). Purpuriforme und hämorrhagische Krankheitsbilder der Haut. In: Blume-Peytavi, U., et al. Therapie der Hautkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56219-8_28

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  • DOI: https://doi.org/10.1007/978-3-642-56219-8_28

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