Zusammenfassung
Blutaustritte aus dem Gefäßnetz der Haut können morphologisch unterschiedlich aussehen: In vielen Fällen stellen sie sich in Form stecknadelkopfgroßer Punktblutungen aus den oberflächlichen Kapillaren des Stratum papilläre dar, die als „Purpura” im engeren Sinne aufzufassen sind; zum anderen treten sie als größere Hautblutungen, d.h. als Hämorrhagien und Suffusionen, aus dem tief gelegenen korialen Gefäßplexus auf. Vielfach entsteht an der Haut ein buntes Bild, das entweder auf eine spezifische Dermatose oder aber auf eine allgemeine hämorrhagische Diathese hinweisen und damit diagnostische Bedeutung haben kann, z.B. zur Erkennung einer hämatologischen Erkrankung (Abb. 28.1).
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Literatur zu Kapitel 28
Allen NB, Bressler PB (1997) Diagnosis and treatment of the systemic and cutaneous necrotizing vasculitis syndromes. Med Clin North Am 81: 243–259
Andressen JC (1994) Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. N Engl J Med 330:1560–1564
Auletta MJ, Headington JT (1988) Purpura fulminans. A cutaneous manifestation of severe protein C deficiency. Arch Dermatol 124:1387–1391
Barrios NJ, Humbert JR, McNeil J (1993) Treatment of acute idiopathic thrombocytopenic purpura with high-dose methylprednisolone and Immunglobulin. Acta Haematol 89: 6–9
Ben-Yehuda D, Gillis S, Eldor A (1994) Clinical and therapeutic experience in 712 Israeli patients with idiopathic thrombocytopenic purpura. Acta Haematol 91:1–6
Berchtold P (1993) Kostenbewußtes Vorgehen bei der Behandlung der autoimmunthrombozytopenischen Purpura. Ther Umsch 50: 88–93
Blanchette VS, Kirby MA, Turner C (1992) Role of intravenous Immunglobulin G in autoimmune hematologic disorders. Semin Hematol 29 [Suppl]: 72–82
Blanchette V, Freedman J, Garvey B (1998) Management of chronic immune thrombocytopenic purpura in children and adults. Semin Hematol 35:36–51
Blanco R, Martinez-Taboada VM, Rodriguez-Valverde V, Garcia-Fuentes M (1998) Cutaneous vasculitis in children and adults. Associated diseases and etiologic factors in 303 patients. Medicine (Baltimore) 77:403–418
Clouse LH, Comp PC (1986) The regulation of hemostasis: the protein C system. N Engl J Med 314:1298–1304
Collins PW, Newland AC (1992) Treatment modalities of autoimmune blood disorders. Semin Hematol 29: 64–74
D’Angelo A, Vigano-D’Angelo S, Esmon CT, Comp PC (1988) Acquired deficiencies of protein S.J Clin Invest 81:1445–1454
Dickerhoff R, Ruecker A von (2000) The clinical course of immune thrombocytopenic purpura in children who did not receive intravenous immunoglobulins or sustained prednisone treatment. J Pediatr 137: 629–632
Diem E (1989) Pathogenese und Therapie der Heparin-Nekrose. Hautarzt 40: 239
Dragoni F, Arcieri R, Chistolini A, De Sanctis V, Pasqualetti D, Mazzucconi MG (1993) Splenectomy outcome in a hemophilic patient with HIV-related immunethrombocytopenia. Haematologica 78: 61–63
Falanga V, Bontempo FA, Eaglstein WH (1990) Protein C and Protein S plasma levels in patients with lipodermatosclerosis and venous ulceration. Arch Dermatol 126: 1195–1197
Feldmann R, Harms M (1991) Die Bedeutung des Protein-C-Mangels in der Dermatologie. Hautarzt 42: 607–612
Figueroa M, Gehlsen J, Hammond D et al. (1993) Combination chemotherapy in refractory immune thrombocytopenic purpura. N Engl J Med 328:1226–1229
Frey BM,Fopp M (1993) Therapeutische Plasmapherese eine kritische Würdigung unter Berücksichtigung der aktuellen Literatur. Schweiz Med Wochenschr 123:1725–1735
Garcia-Erce JA, Vella JC (1999) Splenectomy and idiopathic thrombocytopenic purpura. Haematologica 84: E04
Geiss-Holtorff R, Hafner G, Prellwitz W (1993) Zur Thromboseprophylaxe bei Protein-C-Mangel. Monatsschr Kinderheilkd 141:478–480
Gibson LE, Su WP (1995) Cutaneous vasculitis. Rheum Dis Clin North Am 21:1097–1113
Gunsilius E, Seifried E (1993) Therapie der Autoim-munthrombozytopenie des Erwachsenen. Infusionsther Transfusionsmed 20 [Suppl 1]: 87–98
Hord JD, Grossman NJ (1993) Intravenous corticosteroids versus intravenous gammaglobulin in the treatment of acute immune thrombocytopenic purpura. Pediatr Hematol Oncol 10:323–327
Israels SJ, Seshia SS (1987) Childhood stroke associated with protein C or S deficiency. J Pediatr 111:562–564
Jager D, Huppe D, Weber A et al. (1994) Pfortaderthrombose bei Protein-C-Mangel: Erfolgreiche Fibrinolysetherapie mittels ultrahochdosierter Streptokinase. Med Klin 89: 453–455
Knees U, Macdonald E, Stiegler H et al. (1993) Beckenvenenthrombose bei Protein-C-Mangel nach infektioser Mononukleose. Monatschr Kinderheilkd 141:928–931
Korsten S, Reis HE (1992) Erworbener Protein-C-Mangel bei Colitis ulcerosa. Ursache thromboembolischer Komplikationen. Dtsch Med Wochenschr 117: 419–424
Krizsa J, Hunyadi J, Dobozy A (1992) PUVA treatment of pigmented purpuric lichenoid dermatitis (Gougerot-Blum). J Am Acad Dermatol 27: 778–780
Lazareth I (1989) La protèine C en dermatologie. Ann Dermatol Vénéréol 116:591–593
Lilleyman JS (1999) Management of childhood idiopathic thrombocytopenic purpura. Br J Haematol 105: 871–875
Lotti T, Ghersetich I, Comacchi C, Jorizzo JL (1998) Cutaneous small-vessel vasculitis. J Am Acad Dermatol 39: 667–687
Lotti TM, Comacchi C, Ghersetich I (1999) Cutaneous necrotizing vasculitis. Relation to systemic disease. Adv Exp Med Biol 455:115–125
Marlar RA, Endres Brooks J, Miller C (1985) Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation. Blood 66:59–63
McVerry BA (1985) Management of idiopathic thrombocytopenic purpura in adults. Br J Haematol 59: 203–208
Moreb J, Kitchens CS (1989) Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: report of two cases. Am J Med 87: 207–210
Nydegger U (1994) Alte und neue Aspekte der intravenösen Immunglobulintherapie. Schweiz Med Wochenschr 124: 5–25
Powars DR, Rogers ZR, Patch MJ et al. (1987) Purpura fulminans in meningococcemia: Associaton with acquired deficiencies of protein C and S. N Engl J Med 317:571–572
Reinhold U, Seiter S, Ugurel S, Tilgen W (1999) Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 41: 207–208
Rock GA (2000) Management of thrombotic thrombocytopenic purpura. Br J Haematol 109:496–507
Rock G, Porta C, Bobbio-Pallavicini E (2000) Thrombotic thrombocytopenic purpura treatment in year 2000. Haematologica 85:410–419
Rongioletti F, Pisani S, Ciaccio M, Rebora A (1989) Skin necrosis due to intravenous Heparin. Dermatologica 178: 47–50
Rose M, Rowe JM, Eldor A (1993) The changing course of thrombotic thrombocytopenic purpura and modern therapy. Blood Rev 7:94–103
Smith JGJ (1995) Vasculitis. J Dermatol 22: 812–822
Stadler R, Ruszczak Z (1995) Therapeutic guidelines in vasculitis. Int Angiol 14:188–196
Tamaki K, Yasaka N, Osada A, Shibagaki N, Furue M (1995) Successful treatment of pigmented purpuric dermatosis with griseofulvin. Br J Dermatol 132:159–160
Teepe RGC, Broekmans AW, Vermeer BJ et al. (1986) Recurrent coumarin-induced skin necrosis in a patient with an acquired functional protein C deficiency. Arch Dermatol 122:1408–1412
Tohda S, Ohkusa T (2000) Resolution of refractory idiopathic thrombocytopenic purpura after eradication of helicobacter pylori. Am I Hematol 65:329–330
Tromm A, Huppe D, May B (1992) Protein-C-Mangel bei Colitis ulcerosa. Dtsch Med Wochenschr 117:1130–1131
Tsankov N, Angelova I, Kazandjieva J (1999) Topical modalities for the treatment of cutaneous vasculitis. Clin Dermatol 17: 649–653
Vogel JJ, Moerloose PA de, Bounameaux H (1989) Protein-C deficiency and pregnancy: a case report. Obstet Gynecol 73:455–456
Witt I (1993) Venenthrombosen und hereditärer Protein-C-Mangel. Dtsch Med Wochenschr 118:766–767
Zouboulis CC, Gollnick H, Weber S, Peter HH, Orfanos CE (1991) Intravascular coagulation necrosis of the skin associated with cryofibrinogenemia, diabetes mellitus, and cardiolipin autoantibodies. J Am Acad Dermatol 25: 882–888
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Orfanos, C.E., Garbe, C. (2002). Purpuriforme und hämorrhagische Krankheitsbilder der Haut. In: Blume-Peytavi, U., et al. Therapie der Hautkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56219-8_28
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