Einfluss von Celebrex und Zyflo auf die Lebermetastasierung und die Lipidperoxidation beim Pankreaskarzinom im Syrischen Hamster
Selective inhibition of eicosanoid synthesis is supposed to have effects on carcinogenesis. However, it is still unknown whether pancreatic cancer might be influenced as well. Therefore we evaluated the impact of selective cyclooxygenase-2 inhibitor Celebrex and selective 5-lipoxygenase inhibitor Zyflo on liver metastasis in a solid model of chemically induced pancreatic adenocarcinoma in Syrian hamsters. In week 33 the animals were sacrified and incidence of pancreatic carcinomas and liver metastases was determined. Furthermore, number and size of liver metastases were measured. Biochemically, activities of antioxidative enzymes and concentration of products of lipidperoxidation were determined in liver metastases and non-metastatic hepatic tissue. The incidence, number and size of liver metastases were decreased by combined therapy of Zyflo and Celebrex. Furthermore, activity of antioxidative enzymes was increased and concentration of lipidperoxidation was decreased in non-metastatic hepatic tissue.Accordingly, combined therapy increased lipidperoxidation in liver metastases. Thus the combination of Celebrex and Zyflo might be a new concept in advanced pancreatic cancer to decrease tumor growth in liver metastases.
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