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Cardiopulmonary Interactions and Gas Exchange During Weaning from Mechanical Ventilation

  • Conference paper
Mechanical Ventilation and Weaning

Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 36))

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Abstract

The major function of the lung is to exchange physiological (respiratory) gases, namely, oxygen (O2) and carbon dioxide (CO2). In normal conditions, an equilibrium between oxygen uptake (VO2) and carbon dioxide elimination (VCO2) in the lungs, and the metabolic demands regarding oxygen consumption and carbon dioxide production, must be attained with whatever partial pressures of both gases in arterial blood are necessary to achieve this equilibrium. Only when the lungs fail as a gas exchanger do arterial hypoxemia and hypercapnia or both appear, and respiratory failure ensues. Arterial oxygen (PaO2) and carbon dioxide (PaCO2) tensions are the directly measurable end-point variables used routinely by clinicians to properly manage patients with acute respiratory failure. When this is severe, mechanical ventilation is then considered the best strategy for treating patients. Traditionally, the mechanisms of hypoxemia are alveolar hypoventilation, limitation of alveolar to end-capillary O2 diffusion, shunt, and ventilation-perfusion (VA/Q) mismatching; major causes of hypercapnia are alveolar hypoventilation and VA/Q inequalities [1].

Supported by the Comissionat per a Universitats i Recerca, Generalitat de Catalunya (1999 SGR 00228)

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Authors
  1. M. Ferrer
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  2. J. Roca
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  3. R. Rodriguez-Roisin
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Editor information

Editors and Affiliations

  1. Servei de Medicina Intensiva, Hospital de la Sante Creu i Sant Pau, Av. S.A. Maria Claret 167, 08025, Barcelona, Spain

    Jordi Mancebo MD (Associate Professor of Medicine) & Alvar Net MD (Professor of Medicine) (Associate Professor of Medicine) &  (Professor of Medicine)

  2. Service Réanimation Médicale, Hôpital Henri Mondor, 51, Av. Du Mal de Lattre de Tassigny, F-94010, Créteil cedex, France

    Laurent Brochard MD (Professor of Medicine) (Professor of Medicine)

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© 2003 Springer-Verlag Berlin Heidelberg

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Ferrer, M., Roca, J., Rodriguez-Roisin, R. (2003). Cardiopulmonary Interactions and Gas Exchange During Weaning from Mechanical Ventilation. In: Mancebo, J., Net, A., Brochard, L. (eds) Mechanical Ventilation and Weaning. Update in Intensive Care Medicine, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56112-2_11

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  • DOI: https://doi.org/10.1007/978-3-642-56112-2_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-44181-6

  • Online ISBN: 978-3-642-56112-2

  • eBook Packages: Springer Book Archive

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