Mechanisms of Humoral Immunity Explored Through Studies of LCMV Infection
Prolonged synthesis of antigen-specific antibody is one of the cardinal features of successful vaccination and one of the key parameters used to demonstrate immunological memory. For years, long-term antibody production was attributed solely to the continuous stimulation and differentiation of memory B cells into antibody-secreting plasma cells. However, several studies have now revealed that long-lived plasma cells, most of which reside in the bone marrow, represent a previously overlooked mechanism for sustaining long-term humoral immunity. In this regard, analysis of the antiviral antibody response that occurs following acute infection with lymphocytic choriomeningitis virus (LCMV) has been instrumental in developing our current understanding of the mechanisms underlying long-term antibody synthesis.
KeywordsAcetyl Lysozyme Editing Doyle Measle
Unable to display preview. Download preview PDF.
- Anderson RE, Lefkovits I (1980) Effects of irradiation on the in vitro immune response. Expl Cell Biol 48:255–278Google Scholar
- Bachman MF, Kundig TM, Odermatt B, Hengartner H, Zinkernagel RM (1994) Free recirculation of memory B cells versus antigen-dependent differentiation to antibody forming cells. J Immunol 153:3386–3397Google Scholar
- Baldridge JR, McGraw TS, Paoletti A, Buchmeier MJ (1997) Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells. J Virol 71:755–758Google Scholar
- Holt LB (1950) Developments in diphtheria prophylaxis. William Heinemann, Ltd. London.Google Scholar
- Lehmann-Grube F, Peralta M, Bruns M, Lohler J (1983) Persistent infection of mice with the lymphocytic choriomeningitis virus. In: (Fraenkel-Conrat H, Wagner RR) (eds) Comprehensive virology. Plenum Publishing, New York, pp 43–103Google Scholar
- Ochsenbein AF, Pinschewer DD, Sierro S, Horvath E, Hengartner H, Zinkernagel RM (2000) Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs. Proc Natl Acad Sci USA 97:13263–13268PubMedCrossRefGoogle Scholar
- Sawyer WA (1931) Persistence of yellow fever immunity. J Prev Med 5:413–428Google Scholar
- Seiler P, Brundler MA, Zimmermann C, Weibel D, Bruns M, Hengartner H, Zinkernagel RM (1998a) Induction of protective cytotoxic T cell responses in the presence of high titers of virus-neutralizing antibodies:implications for passive and active immunization. J Exp Med 187:649–654PubMedCrossRefGoogle Scholar