Mechanisms of Humoral Immunity Explored Through Studies of LCMV Infection

  • M. K. Slifka
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 263)


Prolonged synthesis of antigen-specific antibody is one of the cardinal features of successful vaccination and one of the key parameters used to demonstrate immunological memory. For years, long-term antibody production was attributed solely to the continuous stimulation and differentiation of memory B cells into antibody-secreting plasma cells. However, several studies have now revealed that long-lived plasma cells, most of which reside in the bone marrow, represent a previously overlooked mechanism for sustaining long-term humoral immunity. In this regard, analysis of the antiviral antibody response that occurs following acute infection with lymphocytic choriomeningitis virus (LCMV) has been instrumental in developing our current understanding of the mechanisms underlying long-term antibody synthesis.


Plasma Cell Humoral Immunity Affinity Maturation Lymphocytic Choriomeningitis Lymphocytic Choriomeningitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • M. K. Slifka
    • 1
  1. 1.OHSU Vaccine and Gene Therapy InstituteBeavertonUSA

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