Abstract
When dopamine is released from dopaminergic neurons at the synapse, it quickly binds to its receptors that are located on dendrites or nerve terminals of target neurons as well as on dopaminergic neurons themselves. Interactions between dopamine and its receptors then leads rapidly (from a few hundred milliseconds to several seconds) to electrophysiological changes in those target neurons. These electrophysiological changes mediate the acute effects of dopaminergic transmission on the functioning of neural circuits and thereby on behavior.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Atkins J, Carlezon WA, Chlan J, Ny HE, Nestler EJ (1999) Region-specific induction of ΔFosB by repeated administration of typical versus atypical antipsychotic drugs. Synapse 33:118–128
Berretta S, Robertson HA, Graybiel AM (1993) Neurochemically specialized projection neurons of the striatum respond differentially to psychomotor stimulants. Prog Brain Res 99:201–205
Carlezon WA Jr, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ (1998) Regulation of cocaine reward by CREB. Science 282:2272–2275
Cole RL, Konradi C, Douglass J, Hyman SE (1995) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813–823
De Cesare D, Fimia GM, Sassone-Corsi P (1999) Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci 24:281–285
Deutch AY (1994) Identification of the neural systems subserving the actions of clozapine:clues from immediate-early gene expression. J Clin Psychiatry 55 Suppl B:37–42
Doucet J-P, Nakabeppu Y, Bedard PJ, Hope BT, Nestler EJ, Jasmin B, Chen JS, Iadarola MJ, St-Jean M, Wigle N, Blanchet P, Grondin R, Robertson GS (1996) Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of striatal ΔFosB expression. Eur J Neurosci 8:365–381
Fibiger HC (1994) Neuroanatomical targets of neuroleptic drugs as revealed by Fos immunochemistry. J Clin Psychiatry 55 Suppl B:33–36
Finkbeiner S, Greenberg ME (1998) Ca2+ channel-regulated neuronal gene expression. J Neurobiol 37:171–189
Gainetdinov RR, Jones SR, Fumagalli F, Wightman RM, Caron MG (1998) Reevaluation of the role of the dopamine transporter in dopamine system homeostasis. Brain Res Rev 26:148–153
Gerfen CR, Keefe KA, Steiner H (1998) Dopamine-mediated gene regulation in the striatum. Adv Pharmacol 42:670–673
Goldman PS, Tran VK, Goodman RH (1996) The multifunctional role of the coactivator CBP in transcriptional regulation. Rec Prog Hormone Res 52:103–119
Graybiel AM, Moratalla R, Robertson HA (1990) Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc Natl Acad Sci USA 87:6912–6916
Hiroi N, Graybiel AM (1996) Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum. J Comp Neurol 374:70–83
Hiroi N, Brown J, Ye H, Saudou F, Vaidya VA, Duman RS, Greenberg ME, Nestler EJ (1998) Essential role of the fosB gene in molecular, cellular, and behavioral actions of electroconvulsive seizures. J Neurosci 18:6952–6962
Hope B, Kosofsky B, Hyman SE, Nestler EJ (1992) Regulation of IEG expression and AP-1 binding by chronic cocaine in the rat nucleus accumbens. Proc Natl Acad Sci USA 89:5764–5768
Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, Nestler EJ (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235–1244
Hyman SE, Nestler EJ (1999) Principles of molecular biology. In: Charney DS, Nestler EJ, Bunney BS (eds) Neurobiological Foundations of Psychiatry. Oxford University Press, pp 73–85
Janknecht R (1995) Regulation of the c-fos promoter. Immunobiology 193:137–142
Kano T, Suzuki Y, Shibuya M, Kiuchi K, Hagiwara M (1995) Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. Neuroreport 6:2197–200
Kelz MB, Chen JS, Carlezon WA, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang Y-J, Marotti L, Self SW, Tkatch R, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ (1999) Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 401:272–276
Konradi C, Cole RL, Heckers S, Hyman SE (1994) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 14:5623–5634
Kosofsky BE, Genova LM, Hyman SE (1995) Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum. J Comp Neurol 351:41–50
Kreek MJ (1996) Cocaine, dopamine and the endogenous opioid system. J Addictive Dis 15:73–96
Lezcano N, Mrzijak L, Eubanks S, Levenson R, Goldman-Rakic P, Bergson C (2000) Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. Science 287:1660–1664
Luo Y, Kokkonen GC, Wang X, Neve KA, Roth GS (1998) D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells. J Neurochem 71:980–990
McGinty JF, Wang JQ (1998) Drugs of abuse and striatal gene expression. Adv Pharmacol 42:1017–1019
Merchant KM, Dobie DJ, Filloux FM, Totzke M, Aravagiri M, Dorsa DM (1994) Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions. J Pharmacol Exp Ther 271:460–471
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998) Dopamine receptors:from structure to function. Physiol Rev 78:189–225
Morgan JI, Curran T (1995) Immediate-early genes: ten years on. Trends Neurosci 18:66–67
Moratalla R, Elibol B, Vallejo M, Graybiel AM (1996) Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron 17:147–156
Nestler EJ, Aghajanian GK (1997) Molecular and cellular basis of addiction. Science 278:58–63
Nestler EJ, Duman RS (1999) G proteins, In: Siegel GJ, Agranoff BW, Alberts RW, Fisher SK, Uhler MD (eds) Basic Neurochemistry, 6th ed., Lippincott-Raven Publishers, pp 401–414
Nestler EJ, Greengard P (1999) Serine and threonine phosphorylation, In: Basic Neurochemistry, 6th ed., ed. by GJ Siegel, BW Agranoff, RW Alberts, SK Fisher, MD Uhler, Lippincott-Raven Publishers, pp 471–496
Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE (1992) Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci USA 89:4270–4274
Nye H, Hope BT, Kelz M, Iadarol, M, Nestler EJ (1995) Pharmacological studies of the regulation by cocaine of chronic Fra (Fos-related antigen) induction in the striatum and nucleus accumbens. J Pharmacol Exp Ther 275:1671–1680
O’Donovan KJ, Tourtellotte WG, Millbrandt J, Baraban JM (1999) The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci 22:167–173
Robertson GS, Tetzlaff W, Bedard A, St-Jean M, Wigle N (1995) C-fos mediates antipsychotic-induced neurotensin gene expression in the rodent striatum. Neuroscience 67:325–344
Robinson TE, Kolb B (1997) Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J Neurosci 17:8491–8497
Ross J (1996) Control of messenger RNA stability in higher eukaryotes. Trends Genetics 12:171–175
Schwarzschild MA, Cole RL, Hyman SE (1997) Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-l-mediated transcription in striatal neurons. J Neurosci 17:3455–3466
Seeburg PH, Higuchi M, Sprengel R (1998) RNA editing of brain glutamate receptor channels: mechanism and physiology. Brain Res Rev 26:217–229
Seidah NG, Chretien M (1997) Eukaryotic protein processing: endoproteolysis of precursor proteins. Curr Op Biotechnol 8:602–607
Self DW, Genova LM, Hope BT, Barnhart WJ, Spencer JJ, Nestler EJ (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18:1848–1859
Shippenberg TS, Rea W (1997) Sensitization to the behavioral effects of cocaine:modulation by dynorphin and kappa-opioid receptor agonists. Pharmacol Biochem Behav 57:449–455
Sibley DR (1999) New insights into dopaminergic receptor function using antisense and genetically altered animals. Annu Rev Pharmacol Toxicol 39:313–341
Surmeier DJ, Bargas J, Hemmings HC Jr, Nairn AC, Greengard P (1995) Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron 14:385–397
Turgeon SM, Pollack AE, Fink JS (1997) Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization. Brain Res 749:120–126
Welsh GI, Hall DA, Warnes A, Strange PG, Proud CG (1998) Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D2 dopamine receptors. J Neurochem 70:2139–2146
White FJ, Kalivas PW (1998) Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Dependence 51:141–153
Xing L, Quinn PG (1993) Involvement of 3’,5.’-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene. Mol Endocrinol 7:1484–1494
Young ST, Porrino LJ, Iadarola MJ (1991) Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc Natl Acad Sci USA 88:1291–1295
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Nestler, E.J. (2002). Dopamine and Gene Expression. In: Di Chiara, G. (eds) Dopamine in the CNS I. Handbook of Experimental Pharmacology, vol 154 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56051-4_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-56051-4_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62726-2
Online ISBN: 978-3-642-56051-4
eBook Packages: Springer Book Archive