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Single-Molecule Analysis

  • Chapter
Noncontact Atomic Force Microscopy

Part of the book series: NanoScience and Technology ((NANO))

Abstract

In this chapter we describe how the feasibility of NC-AFM in single-molecule analysis has been demonstrated experimentally. Carboxylates (RCOO¯ ) with different Rs are identified molecule-by-molecule on the TiO2(110) substrate. The microscope topography determined with a constant shift of the cantilever oscillation frequency exhibits a good correlation with the physical topography of the carboxylates with R = H, CH3, C(CH3)3 and C≡CH. The molecule-dependent microscope topography was reproduced in a numerical simulation with the van der Waals force pulling the tip into the surface as described by a Lennard-Jones potential. The constant frequency shift topography of a series of fluorine-substituted acetates (R = CH3, CHF2, and CF3) revealed that the intramolecular electric polarization perturbs the tip—molecule force through electrostatic couplings.

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Authors
  1. Akira Sasahara
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  2. Hiroshi Onishi
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Editor information

Editors and Affiliations

  1. Department of Electronic Engineering, Graduate School of Engineering, Osaka University, Yamada-Oka 2-1, Suita, 565-0871, Japan

    S. Morita

  2. Institute of Applied Physics, MARCH, University of Hamburg, Jungiusstrasse 11, 20355, Hamburg, Germany

    R. Wiesendanger

  3. Department of Physics and Astronomy, Condensed Matter Division, University of Basel, Klingelbergstrasse 82, 4056, Basel, Switzerland

    E. Meyer

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© 2002 Springer-Verlag Berlin Heidelberg

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Sasahara, A., Onishi, H. (2002). Single-Molecule Analysis. In: Morita, S., Wiesendanger, R., Meyer, E. (eds) Noncontact Atomic Force Microscopy. NanoScience and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56019-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-56019-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62772-9

  • Online ISBN: 978-3-642-56019-4

  • eBook Packages: Springer Book Archive

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