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Notch Signaling in the Brain: More than Just a Developmental Story

  • Conference paper
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Abstract

Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain aging and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cell-fate decisions during early neural development. However, the action of this evolutionarily conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. Recent evidence obtained from works in a variety of species indicates that the Notch signal affects cell fate acquisition throughout life by regulating the ability of neural cells to respond to the various proliferation, differentiation, or apoptotic cues. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of adult-onset neurological disorders, such as the presenilinlinked form of Alzheimer’s disease (AD) and cerebral arteriopathy CADASIL. Here we present an overview of Notch signaling and its role in the nervous system of vertebrates during their life span, from the very first stages of neurogenesis and neuronal differentiation during development to the maintenance of cellular phenotype in the mature and diseased brain.

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Authors
  1. N. Šestan
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  2. P. Rakic
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Editors and Affiliations

  1. Fondation IPSEN, Pour la Recherche Thérapeutique, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen Ph. D.

  2. Institut Pasteur, Unité de Biologie Moléculaire de l’Expression Génique URA 1773 CNRS, 25 rue du Dr Roux, 75724, Paris Cedex 15, France

    Alain Israël Dr., Ph. D.

  3. Laboratory for Neuronal Cell Biology Center for Human Genetics, KUL-Gasthuisberg and Flanders Interuniversity Institute for Biotechnology, (VIB04) Herestraat 49, 3000, Leuven, Belgium

    Bart De Strooper Ph. D.

  4. Institut de Pharmacologie, Moléculaire et Cellulaire CNRS UPR 411, 660, route des Lucioles, Sophia Antipolis, Valbonne, 06560, France

    Frédéric Checler Ph. D.

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© 2002 Springer-Verlag Berlin Heidelberg

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Šestan, N., Rakic, P. (2002). Notch Signaling in the Brain: More than Just a Developmental Story. In: Christen, Y., Israël, A., De Strooper, B., Checler, F. (eds) Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55996-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-55996-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62767-5

  • Online ISBN: 978-3-642-55996-9

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