Abstract
The mechanisms by which mast cells play a role in IgE-dependent allergie reactions and secrete histamine and other inflammatory mediators are known in considerable detail. Mast cells can also be regarded as a cell prototype that combine characteristics of both innate and acquired immune responses. For example, mast cells bind to mannose-specific lectin expressed on enterobacteria [1] and phagocytose and kill enterobateria, suggesting that they are capable of antigen-processing functions [1] classically ascribed to macrophages. Recent data demonstrating their capacity to promote specific immune responses suggest that mast cells may participate as an effector arm of both innate and acquired immune responses.
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Mécheri, S. (2002). MHC Class II-Restricted T Cell Activation by Mouse and Human Mast Cells: Potential Clinical Implications. In: Ring, J., Behrendt, H. (eds) New Trends in Allergy V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55994-5_9
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DOI: https://doi.org/10.1007/978-3-642-55994-5_9
Publisher Name: Springer, Berlin, Heidelberg
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