Modulation of Skin Barrier Function

  • W. Wohlrab
  • C. Huschka
  • D. Fröde
  • J.-M. Schneider


Clinical unaffected skin of patients suffering from atopic eczema is characterized by a high degree of disturbances of structural and functional properties of the stratum corneum [16, 19]. The aim of skin care during a clinical unaffected interval is the reconstruction of disturbed barrier function by substitution of moisturizing substances and lipids. The reconstruction of the barrier function of the skin is possible both by substitution of reduced lipid components and by stimulation of the epidermal lipid synthesis. Among the lipids fatty acids (FA) play an important role in the synthesis of epidermal lipids [5, 6, 13]. As linked to specific epidermal ceramides, they are involved in forming and maintaining the barrier function of the skin.


Linoleic Acid Oleic Acid Stratum Corneum Human Keratinocytes Skin Barrier Function 
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© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • W. Wohlrab
  • C. Huschka
  • D. Fröde
  • J.-M. Schneider

There are no affiliations available

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