Abstract
Orthotopic liver transplantation has formed an essential part of the therapeutic approach to acute and chronic end-stage liver disease during the past 10 years. The results of pediatric liver transplantation are significantly better than those achieved in adults, the 10-year survival rate exceeding 70% (ELTR 1998) (Fig. 19.1). Of even greater importance, the procedure is increasingly being considered not only to save lives but also to improve the quality of life in children (BEATH et al. 1995; BURDELSKI et al. 1994). The calculated need for liver transplantation in the pediatric age group is approximately 1-2 per 1 million inhabitants annually (Sokal et al. 2000).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Beath SV, Brook GD, Kelly DA, et al (1995) Quality of life after pediatric liver transplantation. Liver Transplant Surg 6:429–435
Burdelski M (1995) Current concepts in diagnosis and therapy of pediatric liver diseases. J Hepatol 23 [Suppl]:45–48
Burdelski M, Rogiers X (1999) Liver transplantation in metabolic disorders. Acta Gastroenterol Belg 62:300–305
Burdelski M, Nolkemper D, Ganschow R, et al (1994) Liver transplantation in children: long-term outcome and quality of life. Eur J Pediatr 158:S34–S42
Burdelski M, Ganschow R, Breivik I, et al (2000) Indication for liver transplantation in children. In: Petar J (ed) Eur Congress IHPBA, Budapest 1999. Monduzzi, Bologna, pp 97–108
Burdelski M (1996) Clinical relevance of familial cholestatic disorders in infancy and childhood. In: Broelsch CE, Burdelski M, Rogiers X (eds) Cholestatic liver diseases in children and adults. Kluwer Academic, Dordrecht, pp 31–36
Choulot JJ, Gautiers M, Eliot N, et al (1979) Les malformations associées à l’atrésie des voies biliaires extrahépatiques. Arch Fr Pédiatr 36:19–24
De Vree JML, Jacquemin E, Sturm E, et al (1998) Mutations of the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci USA 95:282–287
ELTR (1998) ELTR report. Paul Brousse Hospital
Ganschow R, Nolkemper D, Helmke K, et al (2000) Intensive care management after pediatric liver transplantation. A single-center experience. Pediatr Transplant 4:273–279
Harps E, Ganschow R, Nolkemper D, et al (1996) Lebertransplantation bei akutem Leberversagen im Kindesalter (abstract). Transplantationsmedizin 8:544
Helmke K, Burdelski M, Hansen H-C, et al (2000) Detection and monitoring of intracranial pressure dysregulation in liver failure by ultrasound. Transplantation 70:392–395
Kardorff R, Klotz M, Melter M, et al (1999) Prediction of survival in extrahepatic biliary atresia by hepatic Duplex sonography. J Pediatr Gastroenterol Nutr 28:411–417
McBride KE et al (1998) Clinical features of the Alagille syndrome: Frequencies and relation to prognosis. J Pediatr Gastroenterol Nutr 26:580 (abstract)
Oda T, Elkahloun AG, Pike BL, et al (1997) Mutations in the human Jagged 1 gene are responsible for Alagille syndrome. Nat Genet 16:235–242
Rogiers X, Malago M, Gawad K, et al (1996) In-situ splitting of cadaveric livers. The ultimate expansion of a limited donor pool. Ann Surg 224:331–334
Shneider BL (1999) Genetic cholestasis syndromes. J Pediatr Gastroenterol Nutr 28:124–131
Sloof MJH (1995) Reduced size liver transplantation, split liver transplantation and living related liver transplantation in relation to donor organ shortage. Transpl Int 8:65–68
Sokal E, Gleghorn G, Da Silveira TR, et al (2000) Working group on liver and intestinal transplantation in children. Report of the working groups 2000. In: Sokol RJ (ed) 1st world congress of pediatric gastroenterology, hepatology and nutrition, pp 154–170
Stein JE, Vacanti JP (1994) Biliary atresia and other disorders of the extrahepatic biliary tree. In: Suchy FJ (ed) Liver disease in children. Mosby, St Louis, pp 426–442
Stenger AM, Burdelski M, Izbicki JR, et al (1999) Extrahilar mesenteric left portal shunt for portal venous obstruction. Dtsch Gesellsch Chir Kongressbericht 1242–1244
Strautnieks SS, Kajalwalla AF, Turner MS, et al (1998) Identification of a locus for progressive familial intrahepatic cholestasis (PFIC2) on chromosome 2q24. Am J Hum Genet 61:630–633
Weissberg JI, Andres LL, Smith LL, et al (1984) Survival in chronic hepatitis B. Ann Intern Med 101:613–616
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Burdelski, M. (2003). Indications and General Pathology in Pediatric Liver Transplantation. In: Bücheler, E., Nicolas, V., Broelsch, C.E., Rogiers, X., Krupski, G. (eds) Diagnostic and Interventional Radiology in Liver Transplantation. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55955-6_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-55955-6_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62950-1
Online ISBN: 978-3-642-55955-6
eBook Packages: Springer Book Archive