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Proton Beam Irradiation of Choroidal Melanoma: Technique and Results

  • Chapter
Radiotherapy of Intraocular and Orbital Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Since March, 1984, proton beam radiotherapy (PBRT) has been used at the Paul Scherrer Institute (PSI) in a project being conducted jointly with the University Ophthalmological Hospital in Lausanne (Hôpital Ophtalmique Jules Gonin) for the treatment of patients with ocular tumors. Up to now we have treated over 3,000 patients. Among 2,705 cases treated by the end of 1998, there were 2,435 cases of uveal melanoma, 11 of melanoma of the iris, 50 of recurrence of melanoma (some of which had previously been exposed to brachytherapy with Ru-106 or Co-60 plaques), 77 of choroidal hemangioma, 50 of melanoma of the conjunctiva, 32 of intraocular metastases, 34 of age-related macular degeneration, 8 of vascular tumor of the retina, 2 of tumor of the eyelids, and 6 of miscellaneous ocular tumors.

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References

  • Augsburger JJ, Correa ZM, Freire J. et al (1998) Long-term survival in choroidal and ciliary body melanoma after enucleations versus plaque radiation therapy. Ophthalmology 105:1670–1678

    Article  PubMed  CAS  Google Scholar 

  • Augsburger JJ, Schneider S, Freire J. et al (1999) Survival following enucleation versus plaque radiotherapy in statistically matched subgroups of patients with choroidal melanomas: results in patients treated between 1980 and 1987. Graefes Arch Clin Exp Ophthalmol 237:558–567

    Article  PubMed  CAS  Google Scholar 

  • Castro JR, Char DH, Petti PL. et al (1997) 15 years’ experience with helium ion radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys 39:989–996

    Article  PubMed  CAS  Google Scholar 

  • Char DH, Castro JR, Quivey JM. et al (1989) Uveal melanoma radiation. 125–1 brachytherapy versus helium ion irradiation. Ophthalmology 96:1708–15

    PubMed  CAS  Google Scholar 

  • Char DH, Quivey JM, Castro JR. et al (1993) Helium ion versus iodine 125 brachytherapy in the management of uveal melanoma. Ophthalmology 100:1547–1554

    PubMed  CAS  Google Scholar 

  • Char DH, Kroll S, Quivey J, Castro J (1996) Long term visual outcome of radiated uveal melanomas in eyes eligible for randomisation to enucleation versus brachytherapy. Br J Ophthalmol 80: 117–124

    Article  PubMed  CAS  Google Scholar 

  • Char DH, Kroll SM, Castro J (1997) Long-term follow-up after uveal melanoma charged particle therapy. Trans Am Ophthalmol Soc 95:171–187

    PubMed  CAS  Google Scholar 

  • Char DH, Kroll SM, Castro J (1998) Ten-year follow-up of helium ion therapy for uveal melanoma. Am J Ophthalmol 125:81–89

    Article  PubMed  CAS  Google Scholar 

  • Cox D (1972) Regression models and life-tables. J R Stat Soc Ser 34:187–220

    Google Scholar 

  • Egan KM, Gragoudas ES, Seddon JM. et al (1989) The risk of enucleation after proton beam irradiation of uveal melanoma. Ophthalmology 96:1377–1382

    PubMed  CAS  Google Scholar 

  • Egger E, Zografos L, Munkel G et al (1997) Results of proton radiotherapy for uveal melanomas. In: Wiegel T, Bornfeld N, Foerster MH, Hinkelbein W (eds) Radiotherapy of ocular disease. (Frontiers of radiation therapy and oncology, vol 30) Karger, Basel, pp 111–122

    Google Scholar 

  • Goitein M, Miller T (1983) Planning proton therapy of the eye. Med Phys 10:275–283

    Article  PubMed  CAS  Google Scholar 

  • Gragoudas ES, Goitein M, Koehler AM. et al (1977) Proton irradiation of small choroidal malignant melanomas. Am J Ophthalmol 83:665–673

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Goitein M, Verhey L. et al (1980) Proton beam irradiation: an alternative to enucleation for intraocular melanomas. Ophthalmology 87:571–581

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Goitein M, Verhey L. et al (1982) Proton beam irradiation of uveal melanomas. Results of 5 1/2-year study. Arch Ophthalmol 100:928–934

    Article  PubMed  CAS  Google Scholar 

  • Gragoudas ES, Goitein M, Seddon J. et al (1984) Preliminary results of proton beam irradiation of macular and paramacular melanomas. Br J Ophthalmol 68:479–485

    Article  PubMed  CAS  Google Scholar 

  • Gragoudas ES, Seddon JM, Egan KM. et al (1986) Prognostic factors for metastasis following proton beam irradiation of uveal melanomas. Ophthalmology 93:675–680

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Seddon JM, Egan K. et al (1987) Long-term results of proton beam irradiated uveal melanomas. Arch Ophthalmol 94:349–353

    CAS  Google Scholar 

  • Gragoudas ES, Seddon JM, Egan KM. et al (1988) Metastasis from uveal melanoma after proton beam irradiation. Ophthalmology 95:992–999

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Egan KM, Seddon JM. et al (1992) Intraocular recurrence of uveal melanoma after proton beam irradiation. Ophthalmology 99:760–766

    PubMed  CAS  Google Scholar 

  • Kaplan E, Meier P (1958) Nonparametric estimation from incomplete observation. J Am Stat Assoc 53:457–481

    Article  Google Scholar 

  • Karlsson UL, Augsburger JJ, Shields JA. et al (1989) Recurrence of posterior uveal melanoma after 60CO episcleral plaque therapy. Ophthalmology 96:382–388

    PubMed  CAS  Google Scholar 

  • Kleineidam M, Guthoff R, Bentzen SM (1993) Rates of local control, metastasis, and overall survival in patients with posterior uveal melanomas treated with ruthenium-106 plaques. Radiother Oncol 28:148–56

    Article  PubMed  CAS  Google Scholar 

  • Linstadt D, Castro J, Char D. et al (1990) Long-term results of helium ion irradiation of uveal melanoma. Int J Radiat Oncol Biol Phys 19:613–618

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK, Werschnik C, Schuster E (2000) Long-term follow-up of Ru-106/Rh-106 brachytherapy for posterior uveal melanoma. Graefes Arch Clin Exp Ophthalmol 238:129–137

    Article  PubMed  CAS  Google Scholar 

  • Manschot WA, van Strik R (1992) Uveal melanoma: therapeutic consequences of doubling times and irradiation results; a review. Int Ophthalmol 16:91–99

    Article  PubMed  CAS  Google Scholar 

  • Munzenrider JE, Gragoudas ES, Seddon JM. et al (1988) Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. Int J Radiat Oncol Biol Phys 15:553–558

    Article  PubMed  CAS  Google Scholar 

  • Munzenrider JE, Verhey LJ, Gragoudas ES. et al (1989) Conservative treatment of uveal melanoma: local recurrence after proton beam therapy. Int J Radiat Oncol Biol Phys 17:493–498

    Article  PubMed  CAS  Google Scholar 

  • Perret C (1987) The therapy planning program EYE (internal report). Swiss Institute for Nuclear Research, Villigen

    Google Scholar 

  • Petrovich Z, Luxton G, Langholz B. et al (1992) Episcleral plaque radiotherapy in the treatment of uveal melanomas. Int J Radiat Oncol Biol Phys 24:247–251

    Article  PubMed  CAS  Google Scholar 

  • Potter R, Janssen K, Prott FJ et al. (1997) Ruthenium-106 eye plaque brachytherapy in the conservative treatment of uveal melanoma: evaluation of 175 patients treated with 150 Gy from 1981–1989. In: Wiegel T, Bornfeld N, Foerster MH, Hinkelbein W (eds) Radiotherapy of ocular disease. (Frontiers of radiation therapy and oncology, vol 30) Karger, Basel, pp 143–149

    Google Scholar 

  • Seddon JM, Gragoudas ES, Albert DM. et al (1985) Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. Am J Ophthalmol 99:282–290

    PubMed  CAS  Google Scholar 

  • Seddon JM, Gragoudas ES, Polivogianis L. et al (1986) Visual outcome after proton beam irradiation of uveal melanoma. Ophthalmology 93:666–674

    PubMed  CAS  Google Scholar 

  • Seddon JM, Gragoudas ES, Egan KM. et al (1987) Uveal melanomas near the optic disc or fovea. Visual results after proton beam irradiation. Ophthalmology 94:354–361

    PubMed  CAS  Google Scholar 

  • Seddon JM, Gragoudas ES, Egan KM. et al (1990) Relative survival rates after alternative therapies for uveal melanoma. Ophthalmology 97:769–777

    PubMed  CAS  Google Scholar 

  • Sheen M (1995) EYEPLAN proton therapy planning program (internal report). Clatterbridge Centre for Oncology, Bebington UK

    Google Scholar 

  • Shields CL, Shields JA, Karlsson U. et al (1989) Reasons for enucleation after plaque radiotherapy for posterior uveal melanoma. Clinical findings. Ophthalmology 96:919–923

    PubMed  CAS  Google Scholar 

  • Suit HD (1992) Local control and patient survival. Int J Radiat Oncol Biol Phys 23:653–660

    Article  PubMed  CAS  Google Scholar 

  • Suit HD, Westgate SJ (1986) Impact of improved local control on survival. Int J Radiat Oncol Biol Phys 15:453–458

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Radiation Medicine, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

    E. Egger PhD & G. Goitein MD

  2. Hôpital Ophtalmique Jules Gonin, Avenue de France 15, 1004, Lausanne, Switzerland

    L. Zografos MD

Authors
  1. E. Egger PhD
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  2. L. Zografos MD
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  3. G. Goitein MD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA

    Robert H. Sagerman MD, FACR (Professor) (Professor)

  2. Department of Radiotherapy and Radiooncology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Winfried E. Alberti MD (Professor) (Professor)

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© 2003 Springer-Verlag Berlin Heidelberg

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Egger, E., Zografos, L., Goitein, G. (2003). Proton Beam Irradiation of Choroidal Melanoma: Technique and Results. In: Sagerman, R.H., Alberti, W.E. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55910-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-55910-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63147-4

  • Online ISBN: 978-3-642-55910-5

  • eBook Packages: Springer Book Archive

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