Krebs und Ernährung

  • W. Scheppach
  • B. Pool-Zobel
  • J. Stein


Bereits Galen hatte in seinen frühen Schriften gemutmaßt, dass bestimmte Ernährungsformen für die Entstehung bösartiger Tumoren mitverantwortlich seien. Erste dokumentierte systematische Untersuchungen zu dieser Fragestellung stammten von dem englichen Landarzt A. Haviland, der Mitte des des vorigen Jahrhunderts eine vermehrte Rate von Krebserkrankungen in sumpfigen Flussniederungen nachwies. Sein daraus gezogener Rückschluss, dass dem Wasser in der Tuorentstehung eine kausale Bedeutung zukomme, weist auf die bis heute geltende Problematik einer kausalen Interpretation epidemiologischer Zusammenhänge hin [63].


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  1. 1.
    Adlercreutz H (1995) Phytoestrogens: Epidemiology and a possible role in cancer protection. Environ Health Perspect 7: 103–112Google Scholar
  2. 2.
    Alberts DS, Martinez ME, Roe DJ et al. (2000) Lack of effect of a high fiber cereal supplement on the recurrence of colorectal adenomas. N Engl J Med 342: 1156–1162PubMedCrossRefGoogle Scholar
  3. 3.
    α-Tocopherol, β-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330: 1029–1035CrossRefGoogle Scholar
  4. 4.
    Ashwell M (1997) Meat and colorectal cancer — the unanswered questions and the commitment of the Meat and Livestock Commission to finding the answers through strategic research. ECP-News 31: 4–7Google Scholar
  5. 5.
    Awasthi YC, Sharma R, Singhal SS (1994) Human glutathione S-transferases. Int J Biochem 26: 295–308PubMedCrossRefGoogle Scholar
  6. 6.
    Baeuerle PA, Rupec RA, Pahl HL (1996) Reative oxygen intermediates as second messengers of a general pathogen response. Pathol Biol 44: 29–35PubMedGoogle Scholar
  7. 7.
    Banerjee S, Hawksby C, Miller S et al. (1994) Effect of helicobacter pylori and its eradication on gastric juice ascorbic acid. Gut 35: 317–322PubMedCrossRefGoogle Scholar
  8. 8.
    Barber MD (2001) Cancer cachexia and its treatment with fish-oil-enriched nutritional supplementation. Nutrition 17: 751–755PubMedCrossRefGoogle Scholar
  9. 9.
    Baron JA, Beach M, Mandel JS et al. (1999) Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 340: 101–107PubMedCrossRefGoogle Scholar
  10. 10.
    Boeing H, Frentzel-Beyme R (1991) Regional risk factors for stomach cancer in the FRG. Environ Health Perspect 94: 83–89PubMedCrossRefGoogle Scholar
  11. 11.
    Boeing H, Kroke A (1999) Krebsprävention durch Ernährung. Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke und World Cancer Research Fund, Washington D.C.Google Scholar
  12. 12.
    Bogaards JJP, Verhagen H, Willems MI et al. (1994) Consumption of Brussels sprouts results in elevated alpha-class glutathione S-transferase levels in human blood plasma. Carcinogenesis 15: 1073–1075PubMedCrossRefGoogle Scholar
  13. 13.
    Brown JE, Khodr H, Hider RC, Rice-Evans CA (1998) Structural dependence of flavonoid interactions with Cu2+ ions: implications for their antioxidant properties. Biochem J 330: 1173–1178PubMedGoogle Scholar
  14. 14.
    Cao G, Sofic E, Prior RL (1997) Antioxidant and prooxidant behaviour of flavonoids: structure-activity relationships. Free Radical Biol Med 22: 749–760CrossRefGoogle Scholar
  15. 15.
    Chamberlain RS, Fong Y (1999) Nutritional and metabolic aspects of gastrointestinal cancer. Curr Opin Clin Nutr Metab Care 2: 381–385PubMedCrossRefGoogle Scholar
  16. 16.
    Chen ZY, Chan PT, Ho KY et al. (1996) Antioxidant activity of natural flavonoids is governed by number and location of their aromatic hydroxyl groups. Chem Phys Lipids 79: 157–163PubMedCrossRefGoogle Scholar
  17. 17.
    Chyou P, Nomura AM, Stemmermann GN (1995) Diet, alcohol and smoking and cancer of the upper aerodigestive tract: a prospective study among Hawaii Japanese men. Int J Cancer 60: 616–621PubMedCrossRefGoogle Scholar
  18. 18.
    Cimino F, Esposito F, Ammendola R, Russo T (1997) Gene regulation by reactive oxygen species. Curr Topics Cell Regul 35: 123–148CrossRefGoogle Scholar
  19. 19.
    Clark LC, Combs GF, Turnbull BW for the Nutritional Prevention of Cancer Study Group (1996) Effects of selenium supplementation for cancer prevention in patients with karzinoma of the skin. JAMA 276: 1957–1963PubMedCrossRefGoogle Scholar
  20. 20.
    Collins AR, Duthie SJ, Dobson VL (1995) Direct enzymic detection of endogenous oxidative base damage in human lymphocyted DNA. Carcinogenesis 14: 1733–1735CrossRefGoogle Scholar
  21. 21.
    Crawford D, Zbinden I, Amstad P, Cerutti PA (1988) Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene 3: 27–32Google Scholar
  22. 22.
    Csordas A (1995) Toxicology of butyrate and short-chain fatty acids. In: Hill MJ (ed) Role of gut bacteria in human toxicology and pharmacology. Taylor & Francis, London, pp 105–127Google Scholar
  23. 23.
    Cummings JH, Bingham SA (1998) Diet and the prevention of cancer. BMJ 317: 1636–1640PubMedCrossRefGoogle Scholar
  24. 24.
    Deakin M, Elder J, Hendrickse C et al. (1996) Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis 17: 881–884PubMedCrossRefGoogle Scholar
  25. 25.
    Dizdaroglu M (1993) Chemistry of free radical damage to DNA and nucleoproteins. In: Halliwell B, Aruoma OI (eds) DNA and free radicals. Ellis Horwood, New York London, pp 19–40Google Scholar
  26. 26.
    Dreher D, Junod AF (1996) Role of oxygen free radicals in cancer development. Eur J Cancer 32A: 30–38PubMedCrossRefGoogle Scholar
  27. 27.
    Duthie SJ, Collins AR, Duthie GG, Dobson VL (1997) Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes. Mutat Res 393: 223–231PubMedCrossRefGoogle Scholar
  28. 28.
    Eisenbrand G, Tang W (1993) Food-borne heterocyclic amines. Chemistry, formation, occurrence and biological activities. A literature review. Toxicology 84: 1–82PubMedCrossRefGoogle Scholar
  29. 29.
    Erickson R, Ross D, Medina J (1999) Effects of glutamine on head and neck squamous cell karzinoma. Otolaryngol Head Neck Surg 121: 348–354PubMedCrossRefGoogle Scholar
  30. 30.
    Fair WR, Fleshner NE, Heston W (1999).Cancer of the prostate: a nutritional disease? Urology 50: 840–848CrossRefGoogle Scholar
  31. 31.
    Falk RT, Pickle LW, Fontham ET, Correa P, Fraumeni JF (1988) Life-style factors for pancreatic cancer in Lousiana: a case-control study. Am J Epidemiol 128: 324–336PubMedGoogle Scholar
  32. 32.
    Farber E (1984) The multistep nature of cancer development. Cancer Res 44: 4217–4223PubMedGoogle Scholar
  33. 33.
    Fietkau R (2000) Nutritional support of patients during radiotherapy. Nestle Nutr Workshop Ser Clin Perform Progr 4: 225–35CrossRefGoogle Scholar
  34. 34.
    Fotsis T, Pepper MS, Aktas E et al. (1997) Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57: 2916–2921PubMedGoogle Scholar
  35. 35.
    Fuchs CS, Giovannucci EL, Colditz GA et al. (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 340: 169–176PubMedCrossRefGoogle Scholar
  36. 36.
    Giovannucci E, Martinez ME (1996) Tobacco, colorectal cancer, and adenomas: a review of the evidence. J Natl Cancer Inst 88: 1717–1730PubMedCrossRefGoogle Scholar
  37. 37.
    Giovannuci E, Rimm EB, Stampfer MJ et al. (1994) Intake of fat, meat, and fiber in relation to risk of colon cancer in men. Cancer Res 54: 2390–2397Google Scholar
  38. 38.
    Greenberg ER, Baron JA, Tosteson TD et al. (1994) A clinical trial of antioxidant vitamins to prevent colorectal adenomas. N Engl J Med 331: 121–147Google Scholar
  39. 39.
    Grundmann E (1994) Primäre Krebsprävention. Dtsch Ärztebl 91: 2050–2052Google Scholar
  40. 40.
    Haenen GR, Paquay JB, Korthouwer RE, Bast A (1997) Peroxynitrite scavenging by flavonoids. Biochem Biophys Res Commun 236: 591–593PubMedCrossRefGoogle Scholar
  41. 41.
    Hayes JD, Strange RC (1995) Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radical Res 22: 193–207CrossRefGoogle Scholar
  42. 42.
    Helsby NA, Williams J, Kerr D et al. (1997) The isoflavones equol and geistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells. Xenobiotica 27: 587–596PubMedCrossRefGoogle Scholar
  43. 43.
    Heys SD, Walker LG, Smith I, Erimin O (1999) Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer. Ann Surg 229: 467–477PubMedCrossRefGoogle Scholar
  44. 44.
    Hosokawa N, Hirayoshi K, Kudo H et al. (1992) Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Moll Cell Biol 12: 3490–3498Google Scholar
  45. 45.
    Ince N, Wands JR (1999) The increasing incidence of hepatocellular carcinoma. N Engl J Med 340: 798–799PubMedCrossRefGoogle Scholar
  46. 46.
    Jacobson LP, Zhang BC, Zhu YR et al. (1999) Oltipraz chemoprevention trial in Qidong, Peopl’s Republic of China: Study design and clinical outcomes. Cancer Epidemiol Biomarkers Prev 6: 257–265Google Scholar
  47. 47.
    Jordan A, Stein J (1998) Pathophysiologie der Tumorkachexie. Ernährungsumschau 44: 250–254Google Scholar
  48. 48.
    Kasper H (2000) Diäten zur Therapie maligner Tumoren. In: Kasper H (Hrsg) Ernährungsmedizin und Diätetik, 9. Aufl. Urban & Fischer, München, S 503–508Google Scholar
  49. 49.
    Kern KA, Norton JA (1988) Cancer cachexia. JPEN J Parenter Enteral Nutr 12: 286–98PubMedCrossRefGoogle Scholar
  50. 50.
    Kim R, Weissfeld JL, Reynolds JC, Kuller LH (1997) Etiology of Barrett’s metaplasia and esophageal adenokarzinoma. Cancer Epidemiol Biomarkers Prev 6: 369–377PubMedGoogle Scholar
  51. 51.
    Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87: 159–170PubMedCrossRefGoogle Scholar
  52. 52.
    Kune GA, Vitetta L (1992) Alcohol consumption and the etiology of colorectal cancer: A review ot the scientific evidence from 1957 to 1991. Nutr Cancer 18: 97–111PubMedCrossRefGoogle Scholar
  53. 53.
    Langer CJ, Hoffman JP, Ottery FD (2001) Clinical significance of weight loss in cancer patients: rationale for the use of anabolic agents in the treatment of cancer-related cachexia. Nutrition 17: S1–S18PubMedCrossRefGoogle Scholar
  54. 54.
    Langstein HN, Norton JA (1991) Mechanisms of cancer cachexia. Hematol Oncol Clin North Am 5: 103–123PubMedGoogle Scholar
  55. 55.
    LaVecchia C, Tavani A (1998) Fruit and vegetables, and human cancer. Eur J Cancer Prev 7: 3–8CrossRefGoogle Scholar
  56. 55a.
    Legaspi A, Jeevanandam M, Starnes HF, Brennan MF (1987) Whole body lipid and energy metabolism in the cancer patient. Metabolism 36: 958–963PubMedCrossRefGoogle Scholar
  57. 56.
    Mantovani G, Maccio A, Massa E, Madeddu C (2001) Managing cancer-related anorexia/cachexia. Drugs 61: 499–514PubMedCrossRefGoogle Scholar
  58. 57.
    Mantovanig, Maccio A, Lai P et al. (1998) Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxy-progesterone acetate. Semin Oncol 25: S45–S52Google Scholar
  59. 58.
    Martinez ME, Giovannucci E, Spiegelman D, Hunter DJ, Willett WC, Colditz GA (1997) Leisure-time physical activity, body size, and colon cancer in women. J Natl Cancer Inst 89: 948–955PubMedCrossRefGoogle Scholar
  60. 59.
    McGeer AJ, Detsky AS, O’Rourke K (1990) Parenteral nutrition in cancer patients undergoing chemotherapy: a meta-analysis. Nutrition 6: 233–240PubMedGoogle Scholar
  61. 60.
    McMillan DC, Wigmore SJ, Fearon KC et al. (1999) A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. Br J Cancer 79: 495–500PubMedCrossRefGoogle Scholar
  62. 60a.
    Meguid MM; Meguid V (1985) Preoperative identification of the surgical cancer patient in need of postoperative total parenteral nutrition. Cancer 55 (Suppl 1): 258–262Google Scholar
  63. 61.
    Momparler RL, Bovenzi V (2000) DNA methylation and cancer. J Cellul Physiol 183: 145–154PubMedCrossRefGoogle Scholar
  64. 62.
    Moorghen M, Cairns J, Forrester LM et al. (1991) Enhanced expression of glutathione S-transferases in colorectal karzinoma compared to non-neoplastic mucosa. Carcinogenesis 12: 13–17PubMedCrossRefGoogle Scholar
  65. 63.
    Oeser H, Koeppe P (1983) Epidemiologische Zusammenhänge — kritisch betrachtet. In: Schlierf G (Hrsg) Ernährung und Krebs. Wiss Verlagsges, StuttgartGoogle Scholar
  66. 64.
    Ollenschlager G, Sander F. (1985) Indications and results of enteral nutrition in oncology. Z Gastroenterol 23: S64–S76Google Scholar
  67. 65.
    Peters WHM, Boon CEW, Roelofs HMJ, Wobbes T (1992) Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal karzinoma and normal mucosa. Gastroenterology 103: 448–455PubMedGoogle Scholar
  68. 66.
    Plaumann B, Fritsche M, Rimpler H, Brandner G, Hess RD (1996) Flavonoids activate wild-type p53. Oncogene 13: 1605–1614PubMedGoogle Scholar
  69. 67.
    Pool-Zobel BL (2000) Anticarcinogenic factors in plant foods and novel techniques to elucidate their potential chemopreventive activities. In: Eisenbrand G et al. (eds) Carcinogenic and anticarcinogenic factors in food. Wiley-VCH, Weinheim, pp 267–293Google Scholar
  70. 68.
    Pool-Zobel BL, Abrahamse SL, Collins AR et al. (1999) Analysis of DNA strand breaks, oxidized bases and glutathione S-transferase-P1 in human colon cells. Cancer Epidemiol Biomarkers Prev 8: 609–614PubMedGoogle Scholar
  71. 69.
    Pool-Zobel BL, Bub A, Liegibl UM et al. (1998) Mechanisms by which vegetable consumption reduces genetic damage in humans. Cancer Epidemiol Biomarkers Prev 7: 891–899PubMedGoogle Scholar
  72. 70.
    Potter JD (1997) Food, nutrition and cancer: a global perspective. World Cancer Research Fund and American Institute for Cancer Research, Washington D.C.Google Scholar
  73. 71.
    Potter JD (1999) Colorectal cancer: Molecules and populations. J Natl Cancer Inst 91: 916–932PubMedCrossRefGoogle Scholar
  74. 72.
    Pottern LM, Morris LE, Blot WJ et al. (1981) Esophageal cancer among black men in Washington, DC. Alcohol, tobacco, and other risk factors. J Natl Cancer Inst 67: 777–783PubMedGoogle Scholar
  75. 73.
    Primiano T, Sutter TR, Kensler TW (1997) Antioxidant-inducible genes. Adv Pharmacol 38: 293–328PubMedCrossRefGoogle Scholar
  76. 74.
    Roberts-Thompson IC, Ryan P, Khoo KK et al. (1996) Diet, acetylator phenotype, and risk of colorectal neoplasia. Lancet 347: 1372–1374CrossRefGoogle Scholar
  77. 74a.
    Roth E, Funovics J, Winter M et al. (1982) Malnutrition and postoperative complication rate in cancer patients. Langenbecks Arch Chir 357: 77–84PubMedCrossRefGoogle Scholar
  78. 75.
    Schatzkin A, Lanza E, Corle D et al. (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N Engl J Med 342: 1149–1155PubMedCrossRefGoogle Scholar
  79. 76.
    Scheppach W, Bartram HP, Richter F (1995) Role of short-chain fatty acids in the prevention of colorectal cancer. Eur J Cancer 31A: 1077–1080PubMedCrossRefGoogle Scholar
  80. 77.
    Scheppach W, Bingham S, Boutron-Ruault MC et al. (1999) WHO consensus statement on the role of nutrition in colorectal cancer. Eur J Cancer Prev 8: 57–62PubMedCrossRefGoogle Scholar
  81. 78.
    Sen CK, Packer L (1996) Antioxidant and redox regulation of gene transcription. FASEB J 10: 709–720PubMedGoogle Scholar
  82. 79.
    Sinha R, Caporaso N (1999) Diet, genetic susceptibility and human cancer etiology. J Nutr 129: 558S–559SGoogle Scholar
  83. 80.
    Stein J, Schröder O, Bonk M, et al (1996) Induction of glutathione-S-transferase-pi by short-chain fatty acids in the intestinal cell line caco-2. Eur J Clin Invest 26: 84–87PubMedCrossRefGoogle Scholar
  84. 81.
    Sturmer T, Glynn RJ, Lee IM, Manson JE et al. (1998) Aspirin use and colorectal cancer: post-trial follow-up data from the Physicians’ Health Study. Ann Intern Med 128: 713–20PubMedGoogle Scholar
  85. 82.
    Tayek JA, Manglik S, Abemayor E (1997) Insulin secretion, glucose production, and insulin sensitivity in underweight and normal-weight volunteers, and in underweight and normal-weight cancer patients: a clinical research center study. Metabolism 46: 140–145PubMedCrossRefGoogle Scholar
  86. 83.
    Tisdale MJ (2001) Protein loss in cancer cachexia. Science 289: 2293–2294CrossRefGoogle Scholar
  87. 84.
    Tisdale MJ (2001) Cancer anorexia and cachexia. Nutrition 17: 438–442PubMedCrossRefGoogle Scholar
  88. 85.
    Tsuchida S, Sato K (1992) Glutathione transferases and cancer. Crit Rev Biochem Molecul Biol 27: 337–384CrossRefGoogle Scholar
  89. 86.
    Uda Y, Price KR, Williamson G, Rhodes MJC (1997) Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids. Cancer Lett 120: 213–216PubMedCrossRefGoogle Scholar
  90. 87.
    Wigmore SJ, Barber MD, Ross JA et al. (2000) Effect of oral eicosapentanoec acid on weight loss in patients with pancreatic cancer. Nutr Cancer 36: 177–184PubMedCrossRefGoogle Scholar
  91. 88.
    Wigmore SJ, Todorov PT, Barber MD et al. (2000) Characteristics of patients with pancreatic cancer expressing a novel cancer chachetic factor. Br J Surg 87: 53–58PubMedCrossRefGoogle Scholar
  92. 89.
    Willett WC, Stampfer MJ, Colditz GA et al. (1990) Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med 323: 1664–1672PubMedCrossRefGoogle Scholar
  93. 90.
    World Cancer Research Fund, American Institute for Cancer Research (1997) Food, nutrition and the prevention of cancer: a global perspective. American Institute for Cancer Research, Washington D.C.Google Scholar
  94. 91.
    Yoshioka K, Deng T, Cavigelli M, Karin M (1995) Antitumor promotion by phenolic antioxidants: Inhibition of AP-1 activity through induction of fra-expression. Proc Nat Acad Sci 92: 4972–4976PubMedCrossRefGoogle Scholar
  95. 92.
    Zava DT, Duwe G (1997) Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr Cancer 27: 31–40PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • W. Scheppach
  • B. Pool-Zobel
  • J. Stein

There are no affiliations available

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