Skip to main content
SpringerLink
Log in

Arthritis psoriatica

  • Chapter
Molekularmedizinische Grundlagen von rheumatischen Erkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

Zusammenfassung

Die Inzidenz der Psoriasis vulgaris wird mit 0,3–2,5% angegeben (Plunkett u. Marks 1998). Daher kann man die Schuppenflechte mit gutem Grund als eine häufige chronische Erkrankung bezeichnen. Neben der Hautmanifestation wurde bereits 1818 von Alibert ein Zusammenhang zwischen Psoriasis vulgaris und Beschwerden am Bewegungs-und Stützapparat beschrieben (Alibert 1818). Allerdings wurde dies bis etwa in die Mitte des 20. Jahrhunderts häufig als Koinzidenz von Psoriasis und chronischer Polyarthritis gedeutet. Erst danach wurde der Tatsache, dass bei 3–20% der Patienten mit Psoriasis eine entzündliche Gelenkmanifestation auftritt, verstärkt Rechnung getragen. Der Umstand, dass der klinische Verlauf dieser Erkrankung von dem der rheumatoiden Arthritis deutlich unterschiedlich sein kann, dass radiologische Veränderungen bei beiden Erkrankungen differenziert zu betrachten sind und dass die Gelenkentzündung im Rahmen der Psoriasis in der Regel rheumafaktornegativ verläuft, führte zu weitgehendem Konsens, dass die Arthritis psoriatica oder Osteoarthropathia psoriatica als eigene, den seronegativen Spondarthritiden zuzuordnende Entität aufzufassen ist. Sie stellt die zweithäufigste gesicherte Diagnose in Früharthritiskliniken nach der rheumatoiden Arthritis dar (FitzGerald u. Kane 1997, Zink et al. 2001).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 114.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alibert JL (1818) Precis theoretique et practique sur les maladies de la peau. Paris Caille et Ravier 2:21

    Google Scholar 

  • Camp RDR (1992) Psoriasis. In: Champion R, Burton J, Ebling FGJ (eds) Textbook of dermatology, 5th edn. Oxford Blackwell Scientific Publications, Oxford, pp 1391–1457

    Google Scholar 

  • Canete JD, Martinez SE, Farres J et al. (2000) Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies. Ann Rheum Dis 59:263–268

    Article  PubMed  CAS  Google Scholar 

  • Cuellar ML, Espinoza LR (1997) Methotrexate use in psoriasis and psoriatic arthritis. Rheum Dis Clin North Am 23:797–809

    Article  PubMed  CAS  Google Scholar 

  • Daunt AO, Cox NL, Robertson JC, Cawley MI (1987) Indices of disease activity in psoriatic arthritis. J R Soc Med 80:556–558

    PubMed  CAS  Google Scholar 

  • Elkayam O, Ophir J, Yaron M, Caspi D (2000) Psoriatic arthritis: interrelationships between skin and joint manifestations related to onset, course and distribution. Clin Rheumatol 19:301–305

    Article  PubMed  CAS  Google Scholar 

  • Emery P, Zeidler H, Kvien TK et al. (1999) Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double blind comparison. Lancet 354:2106–2111

    Article  PubMed  CAS  Google Scholar 

  • FitzGerald O, Kane D (1997) Clinical, immunopathogenetic and therapeutic aspects of psoriatic arthritis. Curr Opin Rheumatol 9:295–301

    Article  PubMed  CAS  Google Scholar 

  • Gladman DD (1998) Clinical aspects of the spondyloarthropathies. Am J Med Sci 316:234–238

    Article  PubMed  CAS  Google Scholar 

  • Gladman DD, Brockbank J (2000) Psoriatic arthritis. Expert Opin Invest Drugs 9:1511–1522

    Article  CAS  Google Scholar 

  • Gladman DD, Farewell VT (1999) Progression in psoriatic arthritis: role of time varying clinical indicators. J Rheumatol 26:2409–2413

    PubMed  CAS  Google Scholar 

  • Gladman DD, Shuckett R, Russel ML et al. (1987) Psoriatic arthritis: an analysis of 220 patients. Q J Med 62:127–141

    PubMed  CAS  Google Scholar 

  • Gladman DD, Blake R, Brubacher B, Farewell VT (1992) Chloroquine therapy in psoriatic arthritis. J Rheumatol 19:1724–1726

    PubMed  CAS  Google Scholar 

  • Gladman DD, Farewell VT, Kopciuk KA, Coo RJ (1998a) HLA markers and progression in psoriatic arthritis. J Rheumtol 25:730–733

    CAS  Google Scholar 

  • Gladman DD, Farewell VT, Wong K, Husted J (1998b) Mortality studies in psoriatic arthritis: results from a single outpatient center. II. Prognostic indicators for death. Arthritis Rheum 41:1103–1110

    Article  PubMed  CAS  Google Scholar 

  • Gonzales S, Martinez-Borra J, Torre-Alonso JC et al. (1999) The MICA-A9 triplet repeat polymorphism in transmembrane region confers additional suscepitibility to the development of and is independent of the association of Cw*0602 in psoriatis. Arthr Rheum 42:1010–1016

    Article  Google Scholar 

  • Gonzales S, Martinez-Borra J, Lopes-Vasquez A, Garcia-Fernandez S, Torre-Alonso JC, Lopez-Larrea C (2002) MICA rather than MICB, TNFA, or HLADRB1 is associated with suscepitibility to psoriatic arthritis. J Rheumatol 29:973–978

    Google Scholar 

  • Griffiths CEM, Voorhees JJ (1996) Psoriasis, T cells and autoimmunity. J R Soc Med 89:315–319

    PubMed  CAS  Google Scholar 

  • Gu J, Marker-Hermann E, Baeten D et al. (2002) A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondylarthropathy patients. Rheumatology 41:759–766

    Article  PubMed  CAS  Google Scholar 

  • Hawkey CJ, Karrasch JA, Szczepanski L et al. (1998) Omeprazol compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med 338:727–734

    Article  PubMed  CAS  Google Scholar 

  • Hohler T, Grossmann S, Stradmann-Bellinghausen B et al. (2002) Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis. Ann Rheum Dis 61:213–218

    Article  PubMed  CAS  Google Scholar 

  • Jones G, Crotty M, Brooks P (2000) Interventions for psoriatic arthritis. Cochrane Database Syst Rev 2:CD 000212

    Google Scholar 

  • Keyser FD, Mielants H, Veys EM (2001) Current use of biologicals for the treatment of spondyloarthropathies. Expert Opin Pharmacother 2:85–93

    Article  PubMed  CAS  Google Scholar 

  • Kingsley G, Pitzalis C, Kyriazis N, Panayi GS (1988) Abnormal helper-inducer/suppressor-induced T-cell subset distribution and T-cell activation status are common in all types of chronic synovitis. Scand J Immunol 28:225–232

    Article  PubMed  CAS  Google Scholar 

  • Koo T, Nagy Z, Sesztak M, Uifalussy I et al. (2001) Subsets in psoriatic arthritis formed by cluster analysis. Clin Rheumatol 20:36

    Article  PubMed  CAS  Google Scholar 

  • Krueger GG, Duvic M (1994) Epidemiology of psoriasis: clinical issues. J Invest Dermatol 102:14s–18s

    Article  PubMed  CAS  Google Scholar 

  • Lacaille D, Stein HB, Raboud J, Klinkhoff AV (2000) Longterm therapy of psoriatic arthritis: intramuscular gold or methotrexate? J Rheumatol 27:1922–1927

    PubMed  CAS  Google Scholar 

  • Leeb BF, Machold KP, Smolen JS (1996) Diagnose und Therapie der chronischen Polyarthritis. Radiologe 36:657–662

    Article  PubMed  CAS  Google Scholar 

  • Leeb BF, Pflugbeil S, Smolen JS (1997) Sonography of the retrocalcaneal region: Achilles tendon and paratendine structures with respect to chronic inflammatory diseases. Rheumatology in Europe 26/3:93–95

    Google Scholar 

  • Mease PJ, Goffe BS, Metz J, VanderStoep A, Finck B, Burge DJ (2000) Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet 356:385–390

    Article  PubMed  CAS  Google Scholar 

  • Moll JMH, Wright V (1973) Psoriatic arthritis. Semin Arthritis Rheum 3:55–78

    Article  PubMed  CAS  Google Scholar 

  • Nolla JM, Fiter J, Rozadilla A et al. (1999) Bone mineral density in patients with peripheral psoriatic arthritis. Rev Rhum Engl Ed 66:457–461

    PubMed  CAS  Google Scholar 

  • Ogilvie AL, Antoni C, Dechant C et al. (2001) Treatment of psoriatic arthritis with antitumour necrosis factor-alpha antibody clears skin lesions of psoriasis resistant to treatment with methotrexate. Br J Dermatol 200 144 (3):587–589

    Article  Google Scholar 

  • Paiva ES, Macaluso DC, Edwards A, Rosenbaum JT (2000) Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis 59:67–70

    Article  PubMed  CAS  Google Scholar 

  • Panayi GS (1994) Immunology of psoriasis and psoriatic arthritis. Baillieres Clin Rheumatol 8:419–427

    Article  PubMed  CAS  Google Scholar 

  • Partsch G, Petera P, Leeb B et al. (1994) High free and latent collagenase activity in psoriatic arthritis synovial fluids. Br J Rheumatol 33:702–706

    Article  PubMed  CAS  Google Scholar 

  • Partsch G, Leeb B, Stancikova M et al. (1996) Low serum hyaluronan in psoriatic arthritis patients in comparison to rheumatoid arthritis patients. Clin Exp Rheumatol 14:381–386

    PubMed  CAS  Google Scholar 

  • Partsch G, Steiner G, Leeb BF, Dunky A, Broil H, Smolen JS (1997) Highly increased levels of tumor necrosis factor alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid. J Rheumatol 24:518–523

    PubMed  CAS  Google Scholar 

  • Partsch G, Wagner E, Leeb BF, Broil H, Dunky A, Smolen JS (1998) T cell derived cytokines in psoriatic arthritis synovial fluids. Ann Rheum Dis 57:691–693

    Article  PubMed  CAS  Google Scholar 

  • Plunkett A, Marks R (1998) A review of the epidemiology of psoriasis vulgaris in the community. Australas J Dermatol 39:225–232

    Article  PubMed  CAS  Google Scholar 

  • Raffayova H, Rovensky J, Malis F (2000) Treatment with cyclosporin in patients with psoriatic arthritis: results of clinical assessment. Int J Clin Pharmacol Res 20:1–11

    PubMed  CAS  Google Scholar 

  • Rahman P, Gladman DD, Cook RJ, Zhou Y, Young G, Salonen D (1998) Radiological assessment in psoriatic arthritis. Br J Rheumatol 37:760–765

    Article  PubMed  CAS  Google Scholar 

  • Rahman P, Schentag CT, Beaton M, Gladman DD (2000) Comparison of clinical and immunogenetic features in familiar versus sporadic psoriatic arthritis. Clin Exp Rheumatol 18:7–12

    PubMed  CAS  Google Scholar 

  • Roberts MET, Wright V, Hill AGS, Mehra AC (1976) Psoriatic arthritis. A follow-up study. Ann Rheum Dis 35:206–212

    Article  PubMed  CAS  Google Scholar 

  • Rudwaleit M, Hohler T (2001) Cytokine polymorphisms relevant for the spondylarthropathies. Curr Opin Rheumatol 13:250–254

    Article  PubMed  CAS  Google Scholar 

  • Ruzicka T (1996) Psoriatic arthritis. Arch Dermatol 132:215–219

    Article  PubMed  CAS  Google Scholar 

  • Silverstein FF, Graham DY, Senior JR et al. (1995) Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving non steroidal antirheumatic drugs. A randomized, double-blind placebo-controlled trial. Ann Intern Med 123:241–249

    PubMed  CAS  Google Scholar 

  • Smith MD, Roberts-Thomson PJ (1990) Lymphocyte surface marker expression in rheumatic diseases: evidence for prior activation of lymphocytes in vivo. Ann Rheum Dis 49:81–87

    Article  PubMed  CAS  Google Scholar 

  • Smith MD, O’Donnel J, Highton J et al. (1992) Immunohistochemical analysis of synovial membranes from inflammatory and non-inflammatory arthritides: scarcity of CD5 positive B cells and IL2 receptor bearing cells. Pathology 24:19–26

    Article  PubMed  CAS  Google Scholar 

  • Stein CM, Pincus T, Yocum D, Tugwell P et al. (1997) Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks: an open-label extension study. The Methotrexate-Cyclosporine Combination Study Group. Arthritis Rheum 40:1843–1851

    Article  PubMed  CAS  Google Scholar 

  • Taha AS, Hudson N, Hawkey CJ et al. (1996) Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med 334:1435–1439

    Article  PubMed  CAS  Google Scholar 

  • Thomssen H, Hoffmann B, Schank M, Elewaut D, Meyer zum Buschenfelde KH, Marker-Hermann E (2000) There is no disease-specific role for streptococci-responsive synovial T lymphocytes in the pathogenesis of psoriatic arthritis. Med Microbiol Immunol (Berl) 188:203–207

    CAS  Google Scholar 

  • Van Doornum S, Barraclough D, McColl G, Wicks I (2000) SAPHO: rare or just not recognized? Semin Arthritis Rheum 30:70–77

    Article  PubMed  Google Scholar 

  • Yamamoto T, Katayama I, Nishioka K (1999) Peripheral blood mononuclear cell proliferative response against staphylococcal superantigens in patients with psoriasis arthropathy. Eur J Dermatol 9:17–21

    PubMed  CAS  Google Scholar 

  • Zink A, Listing J, Klindworth C, Zeidler H (2001) The national database of the German Collaborative Arthritis Centres: I. Structure, aims, and patients. Ann Rheum Dis 60:199–206

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Burkhard F. Leeb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Josef S. Smolen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Center of Experimental Rheumatology, University Hospital, Gloriastraße 25, 8091, Zürich, Schweiz

    Steffen Gay

  3. Institut für Klinische Immunologie Medizinische Klinik III, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 4a, 91054, Erlangen, Deutschland

    Jochen R. Kalden

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Leeb, B.F., Smolen, J.S. (2003). Arthritis psoriatica. In: Ganten, D., Ruckpaul, K., Gay, S., Kalden, J.R. (eds) Molekularmedizinische Grundlagen von rheumatischen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55803-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55803-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62855-9

  • Online ISBN: 978-3-642-55803-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation