Skip to main content
SpringerLink
Log in

High Dose Chemotherapy in High-Risk Ewing Tumours: Results in 156 (El)CESS Patients

  • Conference paper
Book cover Transplantation in Hematology and Oncology II

  • 91 Accesses

Abstract

Primary metastases and relapse in Ewing tumours represent adverse risk factors leading to a poor prognosis for event free survival (EFS). Whereas patients with localised Ewing tumours have an EFS probability of 0.63 five years after diagnosis, five year-EFS is 0.22 in primary metastatic patients. Survival in patients with relapsed Ewing tumour correlates with the interval between diagnosis of the primary tumour and the relapse. Survival after two years is 0.32 in patients with an early relapse (≤ 24 months) and 0.07 in patients with a late relapse (> 24 months) [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, Swift P, Shimada H, Black CT, Brodeur GM, Gerbing RB, Reynolds CP. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cisretinoic acid. N Engl J Med. 1999;341:1165–1173

    Article  PubMed  CAS  Google Scholar 

  2. Broun ER, Sridhara R, Sledge GW, Loesch D, Kneebone PH, Hanna M, Hromas R, Cornetta K, Einhorn LH. Tandem autotransplantation for the treatment of metastatic breast cancer. J Clin Oncol. 1995;13:2050–2055

    PubMed  CAS  Google Scholar 

  3. Lotz JP, Bouleuc C, Andre T, Touboul E, Macovei C, Hannoun L, Lefranc JP, Houry S, Uzan S, Izrael V. Tandem high-dose chemotherapy with ifosfamide, carboplatin, and teniposide with autologous bone marrow transplantation for the treatment of poor prognosis common epithelial ovarian carcinoma. Cancer. 1996;77:2250–2259

    Article  Google Scholar 

  4. Cohn SL, Moss TJ, Hoover M, Katzenstein HM, Haut PR, Morgan ER, Green AA, Kletzel M. Treatment of poor-risk neuroblastoma patients with high-dose chemotherapy and autologous peripheral stem cell rescue. Bone Marrow Transplant. 1997;20:543–551

    Article  PubMed  CAS  Google Scholar 

  5. Haut PR, Cohn S, Morgan E, Hubbell M, Danner-Koptik K, Olszewski M, Schaff M, Kletzel M. Efficacy of autologous peripheral blood stem cell (PBSC) harvest and engraftment after ablative chemotherapy in pediatric patients. Biol Blood Marrow Transplant. 1998;4:38–42

    Article  PubMed  CAS  Google Scholar 

  6. Diaz MA, Villa M, Madero L, Benito A, Alegre A, Fernandez-Ranada JM. Analysis of engraftment kinetics in pediatric patients undergoing autologous PBPC transplantation. J Hematother. 1998;7:367–373

    Article  PubMed  CAS  Google Scholar 

  7. Brodeur GM, Pritchard J, Berthold F, Carlsen NLT, Castel V, Castleberry RP, De Bernardi B, Evans AE, Favrot M, Hedborg F, Kaneko M, Kemshead J, Lampert F, Lee REJ, Look AT, Pearson ADJ, Philip T, Roald B, Sawada T, Seeger RC, Tsuchida Y, Voute PA. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11:1466–1477

    PubMed  CAS  Google Scholar 

  8. Grupp SA, Stern JW, Bunin N, Nancarrow C, Ross AA, Mogul M, Adams R, Grier HE, Gorlin JB, Shamberger R, Marcus K, Neuberg D, Weinstein H J, Diller L. Tandem high dose therapy in rapid sequence for children with high-risk neuroblastoma. J Clin Onc. 2000;18:2567–2575

    CAS  Google Scholar 

  9. Shpall EJ, Jones RB, Bearman SI, Franklin WA, Archer PG, Curiel T, Bitter M, Claman HN, Stemmer SM, Purdy M, Myers SE, Hami L, Taffs S, Heimfeld S, Hallagan J, Berenson RJ. Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment. J Clin Oncol. 1994;12:28–36

    PubMed  CAS  Google Scholar 

  10. Donovan J, Temel J, Zuckerman A, Gribben J, Fang J, Pierson G, Ross A, Diller L, Grupp SA. CD34 selection as a stem cell purging strategy for neuroblastoma: pre-clinical and clinical studies. Med. Ped. Oncol. 2000;in press

    Google Scholar 

  11. Bearman SI, Anderson GL, Mori M, Hinds MS, Shulman HM, McDonald GB. Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation. J Clin Oncol. 1993;11:1729–1736

    PubMed  CAS  Google Scholar 

  12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481

    Article  Google Scholar 

  13. Matthay KK, Harris R, Reynolds CP, Shimada H, Black T, Stram DO, Seeger RC. Improved eventfree survival for autologous bone marrow transplantation vs chemotherapy in neuroblastoma: a Childrens Cancer Group study. Med Pediatr Oncol. 1998;31:191, O-197

    Google Scholar 

  14. Matthay KK. Impact of myeloablative therapy with bone marrow transplantation in advanced neuroblastoma. Bone Marrow Transplant. 1996;18:S21–24

    PubMed  Google Scholar 

  15. Kletzel M, Longino R, Danner K, Olszewski M, Moss T. Peripheral blood stem cell rescue in children with advanced stage neuroblastoma. Prog Clin Biol Res. 1994;389:513–519

    PubMed  CAS  Google Scholar 

  16. Kletzel M, Abella EM, Sandler ES, Williams LL, Ogden AK, Pollock BH, Wall DA. Thiotepa and cyclophosphamide with stem cell rescue for consolidation therapy for children with high-risk neuroblastoma: a phase I/II study of the Pediatric Blood and Marrow Transplant Consortium. J Pediatr Hematol Oncol. 1998;20:49–54

    Article  PubMed  CAS  Google Scholar 

  17. Handgretinger R, Greil J, Schurmann U, Lang P, Gonzalez-Ramella O, Schmidt I, Fuhrer R, Niethammer D, Klingebiel T. Positive selection and transplantation of peripheral CD34+ progenitor cells: feasibility and purging efficacy in pediatric patients with neuroblastoma. J Hematother. 1997;6:235–242

    Article  PubMed  CAS  Google Scholar 

  18. Kanold J, Yakouben K, Tchirkov A, Carret A-S, Vannier J-P, LeGall E, Bordigoni P, Demeocq F. Long-term results of CD34+ cell transplantation in children with neuroblastoma. Med Pediatr Oncol. 2000;35:1–7

    Article  PubMed  CAS  Google Scholar 

  19. Kanold J, Yakouben K, Tchirkov A, Halle P, Carret AS, Berger M, Rapatel C, deLumley L, Vannier JP, Plantaz D, LeGall E, Lutz P, Mechinaud F, Rialland X, Combaret V, Bordigoni P, Deméocq F. Long-term follow-up after CD34+ cell transplantation in children with neuroblastoma. Blood. 1998;92:445a (abstr 1842)

    Google Scholar 

  20. Philip T, Ladenstein R, Zucker JM, Pinkerton R, Bouffet E, Louis D, Siegert W, Bernard JL, Frappaz D, Coze C. Double megatherapy and autologous bone marrow transplantation for advanced neuroblastoma: the LMCE2 Study. Br J Cancer. 1993;67:119–127

    Article  PubMed  CAS  Google Scholar 

  21. Craft AW, Cotterill SJ, Malcolm AJ, et al. (1998) Ifosfamide containing chemotherapy in Ewing’s sarcoma: The second UKCCSG/MRC Ewing’s Toumors Study (ET-2). J Clin Oncol 16:3628–3633

    PubMed  CAS  Google Scholar 

  22. Kaplan El, Meier P. (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481 (abstract)

    Article  Google Scholar 

  23. Fröhlich B, Ahrens S, Burdach S, et al. (1999) Hochdosistherapie bei primär metastasiertem und rezidiviertem Ewing-Sarkom. Klin Pädiatr 211 284–290

    Article  PubMed  Google Scholar 

  24. Ladenstein R, Gadner H, Hartmann O et al. (1995) Europäische Erfahrung mit Megatherapie und autologer Knochenmarktransplantation bei soliden Tumoren mit ungünstiger Prognose (Ewing-Sarkom, Keimzelltumoren und Hirntumoren). Wien Med Wschr 145: 55–57

    PubMed  CAS  Google Scholar 

  25. Ladenstein R, Lasset C, Pinkerton R, et al. (1995) Impact of megafherapy in children with highrisk Ewing’s tumours in complete remission: a report from the EBMT Solid Tumour Registry. Bone Marrow Transplant 15: 697–705

    PubMed  CAS  Google Scholar 

  26. Ladenstein R, Hartmann O, Pinkerton R, et al. for the EBMT Solid Tumour Pediatric Working Party (1998) A multivariate and matched pair analysis on high-risk Ewing tumour patients undergoing MGT/SCR in Europe. Bone Marrow Transplant 21: 227–227 (abstract)

    Google Scholar 

  27. Atra A, Whelan JS, Calvagna V, et al. (1997) High-dose busulphan/melphalan with autologous stem cell rescue in Ewing’s sarcoma. Bone Marrow Transplant 20: 843–846

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Paediatric Haematology/Oncology, University of Münster, Germany

    B. Fröhlich, S. Ahrens, M. Paulussen & H. Jürgens

  2. Dept. of Paediatrics, University of Halle/Saale, Germany

    S. Burdach

  3. Dept. of Child Health, University of Newcastle-upon-Tyne, UK

    A. Craft

  4. St. Anna Kinderspital, Vienna, Austria

    R. Ladenstein

Authors
  1. B. Fröhlich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Ahrens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Burdach
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Craft
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Ladenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Paulussen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H. Jürgens
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine Hematology/Oncology, University of Münster, Albert-Schweitzer-Straße 33, 48129, Münster, Germany

    W. E. Berdel Prof. Dr. med. , Th. Büchner Prof. Dr. med.  & J. Kienast Prof. Dr. med. ,  & 

  2. Department of Pediatrics Hematology/Oncology, University of Münster, Albert-Schweitzer-Straße 33, 48129, Münster, Germany

    H. Jürgens Prof. Dr. med. , J. Ritter Prof. Dr. med.  & J. Vormoor Dr. med. ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Fröhlich, B. et al. (2003). High Dose Chemotherapy in High-Risk Ewing Tumours: Results in 156 (El)CESS Patients. In: Berdel, W.E., Büchner, T., Kienast, J., Jürgens, H., Ritter, J., Vormoor, J. (eds) Transplantation in Hematology and Oncology II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55774-3_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55774-3_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62660-9

  • Online ISBN: 978-3-642-55774-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation