Abstract
The engraftment after autologous peripheral blood stem cell transplantation (APBSCT) is influenced by several factors. Among these quality of the graft, scheme used for conditioning, intensity of previous chemo and radiotherapy, diagnosis and age of the patients (PAT) were found to be of importance. The use of growth factors (GF) at the harvesting and after APBSCT could have an impact on the recovery of neutrophils (Lowenthal et al. 1998). However, the exact role of GF after APBSCT is not fully established. They could speed up the recovery of neutrophils by 2–6 days but their influence on neutropenia-related complications (incidence of infection, duration of fever, antibiotic treatment and hospitalization as well as cost-effectiveness) is less well defined (Klumpp et al. 1995, Ojeda et al. 1999, Tarella et al. 1998). Moreover, the optimal schedule for post-transplant application of GF is unknown. We performed a pilot study in order to investigate the safety and the efficacy of delaying the initiation of GF after APBSCT to the point when first neutrophils appear in peripheral blood.
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© 2003 Springer-Verlag Berlin Heidelberg
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Faber, E. et al. (2003). A “Single” Delayed Application of G-CSF after Autologous Peripheral Blood Stem Cell Transplantation — A Pilot Study. In: Berdel, W.E., Büchner, T., Kienast, J., Jürgens, H., Ritter, J., Vormoor, J. (eds) Transplantation in Hematology and Oncology II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55774-3_13
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DOI: https://doi.org/10.1007/978-3-642-55774-3_13
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