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Macrophages in the Central and Peripheral Nervous System

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Book cover The Macrophage as Therapeutic Target

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 158))

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Abstract

In the central and peripheral nervous system there are several distinct populations of macrophages. In the brain there are macrophages in the parenchyma and meninges, and there are macrophages associated with the vasculature. The macrophages in the brain parenchyma, the microglia are highly atypical with a distinct morphology and downregulated phenotype. The molecular mechanisms that underpin this unusual phenotype are being unravelled. Microglia rapidly respond to perturbations of their microenvironment and become activated in almost all brain pathologies. There is considerable interest in the possible role that activated microglia may have in brain and spinal cord pathology. The perivascular macrophages abutting the brain vasculature are also highly specialised macrophages and play an important role in communication between systemic inflammation and the brain. There is still much to learn about the role of macrophages in nervous system injury and repair.

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Authors and Affiliations

  1. CNS Inflammation Group, School of Biological Sciences, University of Southampton, SO16 7PX, Southampton, UK

    V. H. Perry

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  1. V. H. Perry
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Editors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK

    Siamon Gordon

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© 2003 Springer-Verlag Berlin Heidelberg

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Perry, V.H. (2003). Macrophages in the Central and Peripheral Nervous System. In: Gordon, S. (eds) The Macrophage as Therapeutic Target. Handbook of Experimental Pharmacology, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55742-2_20

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  • DOI: https://doi.org/10.1007/978-3-642-55742-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62919-8

  • Online ISBN: 978-3-642-55742-2

  • eBook Packages: Springer Book Archive

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