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Human Infection with Foamy Viruses

  • Chapter
Foamy Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 277))

Abstract

Virtually all nonhuman primate species investigated thus far including prosimians, New World and Old World monkeys and apes all harbor distinct and species-specific clades of simian foamy virus (SFV). However, evidence supporting the existence of a human-specific foamy virus (FV) is not yet available. Early reports describing widespread infection of healthy and sick humans with FV could not be confirmed. In contrast, all FV infections documented in humans are of zoonotic origin

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References

  • Ali M, Taylor GP, Pitman RJ, Parker D, Rethwilm A, Cheingsong-Popov R, Weber JN, Bieniasz PD, Bradley J, McClure MO (1996) No evidence of antibody to human foamy virus in widespread human populations. AIDS Res Hum Retrovir 12:14731483

    Google Scholar 

  • Achong BG, Mansell PWA, Epstein MA, Clifford P (1971) An unusual virus in cul-tures from a human nasopharyngeal carcinoma. J Nail Cancer Inst 46:299–302

    CAS  Google Scholar 

  • Achong BG, Epstein MA (1978) Preliminary seroepidemiological studies on the hu-man syncytial virus. J Gen Virol 40:175–181

    Article  PubMed  CAS  Google Scholar 

  • Achong BG, Epstein MA (1983) Naturally occurring antibodies to the human syncytial virus in West Africa. J Med Virol 11:53–57

    Article  PubMed  CAS  Google Scholar 

  • Baum KF (1992) Absence of antibody to human spumaretrovirus in patients with chronic fatigue syndrome. Clin Infect Dis 14:623–624

    Article  Google Scholar 

  • Bieniasz PD, Rethwilm A, Pitman R, Daniel MD, Chrystie I, McClure MO (1995) A comparative study of higher primate foamy viruses, including a new virus from a gorilla. Virology 207:217–228

    Article  PubMed  CAS  Google Scholar 

  • Boneva RS, Grindon AJ, Orton SL, Switzer WM, Shamugam V, Hussain AI, Bhullor VB, Chamberland ME, Heneine W, Folks TM, Chapman LE (2002) Simian foamy virus infection in a blood donor. Transfusion 42:886–891

    Article  PubMed  CAS  Google Scholar 

  • Brown J, Matthews AL, Sandstrom PA, Chapman LE (1998) Xenotransplantation and the risk of retroviral zoonosis. Trends Microbiol 6:411–415

    Article  PubMed  CAS  Google Scholar 

  • Brown P, Nemo G, Gajdusek DC (1978) Human foamy virus: further characterization, seroepidemiology, and relationship to chimpanzee foamy viruses. J Infect Dis 137:421–427

    Article  PubMed  CAS  Google Scholar 

  • Butera ST, Brown J, Callahan ME, Owen SM, Matthews AL, Weigner DD, Chapman LE, Sandstrom PA (2000) Survey of veterinary conference attendees for evidence of zoonotic infection by feline retroviruses. J Am Vet Assoc 217:1475–1479

    Article  CAS  Google Scholar 

  • Callahan ME, Switzer W, Matthews AL, Roberts B, Heneine W, Folks TM, Sandstrom PA (1999) Persistent zoonotic infection of a human with simian foamy virus in the absence of an Intact orf-2 accessory gene. J Virol 73:9619–9624

    PubMed  CAS  Google Scholar 

  • Cameron KR, Birchall SM, Moses MA (1978) Isolation of foamy virus from patient with dialysis encephalopathy. Lancet II:796

    Article  Google Scholar 

  • Cordonnier A, Casella JF, Heidmann T (1995) Isolation of novel human endogenous retrovirus-like elements with foamy virus-related pol sequence. J Virol 69:5890–5897

    Google Scholar 

  • Debons-Guillemin MC, Valla J, Gazeau J, Wybier-Franqui J, Giron ML, Toubert ME, Canivet M, Périès J (1992) No evidence of spumaretrovirus infection markers in 19 cases of de Quervain’s thyroiditis. AIDS Res Hum Retrovir 8:1547

    Article  PubMed  CAS  Google Scholar 

  • Gow JW, Simpson K, Schliephake A, Behan WM, Morrison LJ, Cavanagh H, Rethwilm A, Behan PO (1992) Search for retrovirus in the chronic fatigue syndrome. J Clin Pathol 45:1058–1061

    Article  PubMed  CAS  Google Scholar 

  • Gunn WJ, Komaroff AL, Connell DB, Levine SM, Cheney PR (1993) Inability of retro-viral tests to identify persons with chronic fatigue syndrome. MMWR Morb Mortal Wkly Rep 42:189–190

    Google Scholar 

  • Hahn H, Baunach G, Bräutigam S, Mergia A, Neumann-Haefelin D, Daniel MD, McClure M, Rethwilm A (1994) Reactivity of primate sera to foamy virus Gag and Bet proteins. J Gen Virol 75:2635–2644

    Article  PubMed  CAS  Google Scholar 

  • Heneine W, Woods TC, Sinha SD, Khan AS, Chapman LE, Schonberger LB, Folks TM (1994) Lack of evidence for infection with known human and animal retroviruses in patients with chronic fatigue syndrome. Clin Infect Dis 18 Suppl 1:121–125

    Article  Google Scholar 

  • Heneine W, Musey VC, Sinha SD, Landay A, Northrup G, Khabbaz R, Kaplan JE (1995) Absence of evidence for human spumaretrovirus sequences in patients with Graves’ disease. J Acquir Immun Defic Syndr Hum Retrovir 9:99–101

    Article  CAS  Google Scholar 

  • Heneine W, Switzer WM, Sandstrom P, Brown J, Shanmugam V, Schable CA, Khan A S; Lerche NW, Schweizer M, Neumann-Haefelin D, Chapman LE, Folks TM (1998) Identification of a human population infected with simian foamy virus. Nat Med 4:403–407

    Article  PubMed  CAS  Google Scholar 

  • Herchenröder O, Renne R, Loncar D, Cobb EK, Murthy KK, Schneider J, Mergia A, Luciw PA (1994) Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): High homology to human foamy virus (HFV). Virology 201:187–199

    Article  PubMed  Google Scholar 

  • Hooks JJ, Gibbs CJ (1975) The foamy viruses. Bacteriol Rev 39:169–185

    PubMed  CAS  Google Scholar 

  • Hunsmann G, Flügel RM, Walder R (1990) Retroviral antibodies in Indians. Nature 344:120

    Article  Google Scholar 

  • Lagaye S, Vexiau P, Morozov V, Guénebaut-Claudet V, Tobaly-Tapiero J, Canivet M, Cathelineau G, Périès J, Emanoil-Ravier R (1992) Human spumaretrovirus-related sequences in the DNA of leukocytes from patients with Graves disease. Proc Natl Acad Sci USA 89:10070–10074

    Article  PubMed  CAS  Google Scholar 

  • Larsen RD, Rivera-Marrero CA, Ernst LK, Cummings RD, Lowe JB (1990) Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-G1cNAcalpha(1,3) -galactosyltransferase cDNA. J Biol Chem 265:7055–61

    PubMed  CAS  Google Scholar 

  • Lee H, Kim S, Kang M, Kim W, Cho B J (1998) Prevalence of human foamy virus-related sequences in the Korean population. Biomed Sci 5:267–73

    Article  CAS  Google Scholar 

  • Loh PC, Matsuura F, Mizumoto C (1980) Seroepidemiology of human syncytial virus: antibody prevalence in the Pacific. Intervirology 13:87–90

    Article  PubMed  CAS  Google Scholar 

  • Loh PC. Spumaviruses. In: Levy JA (ed) The Retroviridae, Plenum Press, New York

    Google Scholar 

  • Mahnke C, Kashaiya P, Rössler J, Bannert H, Levin A, Blattner WA, Dietrich M, Lu-ande J, Löchelt M, Friedman-Kien AE, Komaroff AL, Loh PC, Westarp ME, Flügel RM (1992) Human spumavirus antibodies in sera from African patients. Arch Vi-rol 123:243–253

    CAS  Google Scholar 

  • McClure MO, Erlwein 0 (1995) Foamy viruses—pathogenic or therapeutic potential. Rev Med Virol 5:229–237

    Article  Google Scholar 

  • Muller HK, Ball G, Epstein MA, Achong BG, Lenoir G, Levin A (1980) The prevalence of naturally occurring antibodies to human syncytial virus in East African populations. J Gen Virol 47:399–406

    Article  PubMed  CAS  Google Scholar 

  • Nemo GJ, Brown PW, Gibbs CJ Jr, Gajdusek DC (1978) Antigenic relationship of hu-man foamy virus to the simian foamy viruses. Infect Immun 20.69–72

    PubMed  CAS  Google Scholar 

  • Neumann-Haefelin D, Fleps U, Renne R, Schweizer M (1993) Foamy viruses. Intervi-rology 35:196–207

    Google Scholar 

  • Pyykkö I, Vesanen M, Asikainen K, Koskiniemi M, Airaksinen L, Vaheri A (1993) Human spumaretrovirus in the etiology of sudden hearing loss. Acta Otolaryngol 113:109–112

    Article  PubMed  Google Scholar 

  • Pyykkö I, Vesanen M, Asikainen K, Koskiniemi M, Airaksinen L, Vaheri A (1994) Human spumaretrovirus in the etiology of sudden hearing loss. Acta Otolaryngol 114:224

    Article  PubMed  Google Scholar 

  • Rösener M, Hahn H, Kranz M, Heeney J, Rethwilm A (1996) Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis. J Med Virol 48:222–226.

    Article  PubMed  Google Scholar 

  • Rother RP, Fodor WL, Springhorn JP, Birks CW, Setter E, Sandrin MS, Squinto SP, Rollins SA (1995) A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody. J Exp Med 182:1345–1355

    Article  PubMed  CAS  Google Scholar 

  • Saib A, Périès J, de Thé H (1993) A defective human foamy provirus generated by pregenome splicing. EMBO J 12:4439–4444

    PubMed  CAS  Google Scholar 

  • Saib A, Canivet M, Giron ML, Bolgert F, Valla J, Lagaye S, Périès J, de Thé H (1994) Human foamy virus infection in myasthenia gravis. Lancet 343:666

    Article  PubMed  CAS  Google Scholar 

  • Sandstrom PA, Phan K, Switzer W, Chapman L, Heneine W, Folks TM (2000) Simian foamy virus infection among zoo keepers. Lancet 355:551–552

    Article  PubMed  CAS  Google Scholar 

  • Schweizer M, Turek R, Reinhardt M, Neumann-Haefelin D (1994) Absence of foamy virus DNA in Graves’ disease. AIDS Res Hum Retrovir 10:601–605

    Article  PubMed  CAS  Google Scholar 

  • Schweizer M, Turek R, Hahn H, Schliephake A, Netzer KO, Eder G, Reinhardt M, Rethwilm A, Neumann-Haefelin D (1995) Markers of foamy virus (FV) infections in monkeys, apes, and accidentally infected humans: Appropriate testing fails to confirm suspected FIT prevalence in man AIDS Res Hum Retrovir 11:161–170

    CAS  Google Scholar 

  • Schweizer M, Neumann-Haefelin D (1995) Phylogenetic analysis of primate foamy viruses by comparison of pol sequences. Virology 207:577–582

    Article  PubMed  CAS  Google Scholar 

  • Schweizer M, Falcone V, Gänge J, Turek R, Neumann-Haefelin D (1997) Simian foamy virus isolated from an accidentally infected human individual. J Virol 71:4821–4824

    PubMed  CAS  Google Scholar 

  • Schweizer M, Schleer H, Pietrek M, Liegibel J, Falcone V, Neuman-Haefelin D (1999) Genetic Stability of foamy viruses: Long-term study in an African green monkey population. J Virol 73:9256–9265

    PubMed  CAS  Google Scholar 

  • Simonsen L, Heneine W, Sinha SD, Arenberg IK (1994) Absence of evidence for infection with the human spuma retrovirus in an outbreak of Meniere-like vertiginous illness in Wyoming, USA. Acta Oto-Laryngologica 114:223–224

    Article  PubMed  CAS  Google Scholar 

  • Stancek D, Gressnerová M (1974) A viral agent isolated from a patient with subacute de Quervain type thyroiditis. Acta Virol 18:365

    Google Scholar 

  • Stancek D, Stanceková-Gressnerova M, Janotka M, Hnilica P, Oravec D (1975) Isolation and some serological and epidemiological data on the viruses recovered from patients with subacute thyroiditis de Quervain. Med Microbiol Immunol 161:133–144

    Article  PubMed  CAS  Google Scholar 

  • Stancekova M, Stancek D, Ciampor F, Mucha V, Hnilica P (1976) Morphological, cytological and biological observations on viruses isolated from patients with subacute thyroiditis de Quervain. Acta Virol 20:183–188

    PubMed  Google Scholar 

  • Svenningsson A, Lycke J, Svennerholm B, Gronowitz S, Andersen 0 (1992) No evidence for spumavirus or oncovirus infection in relapsing-remitting multiple sclerosis. Ann Neurol 32:711–714

    Article  PubMed  CAS  Google Scholar 

  • Tamura N, Kira S (1995) Human foamy virus and familial Mediterranean fever in Japan. JAMA 274:1509

    Article  PubMed  CAS  Google Scholar 

  • Tobaly-Tapiero J, Bittoun P, Neves M, Guillemin MC, Lecellier CH, Puvion-Dutilleul F, Gicquel B, Zientara S, Giron ML, de The H, Saib A (2000) Isolation and characterization of an equine foamy virus. J Virol 74:4064–4073

    Article  PubMed  CAS  Google Scholar 

  • Von Laer D, Neumann-Haefelin D, Heeney JL, Schweizer M (1996) Lymphocytes are the major reservoir for foamy viruses in peripheral blood. Virology 221:240–244

    Article  Google Scholar 

  • Wallen WC, Sever JL, McFarlin DE, McFarland HF, Traub RG, Rentier B, Greenstein JI, and Moore PM (1979) Attempt to isolate infectious agent from bone-marrow of patients with multiple sclerosis. Lancet II:414–415

    Article  Google Scholar 

  • Weiss RA (1988) Foamy retroviruses: A virus in search of a disease. Nature 333:497498

    Google Scholar 

  • Werner J, Gelderblom H (1979) Isolation of foamy virus from patients with de Quer-vain thyroiditis. Lancet II:258–259

    Article  Google Scholar 

  • Westarp ME, Kornhuber HH, Rössler J, Flügel RM (1992) Human spuma retrovirus antibodies in amyotrophic lateral sclerosis. Neurol Psychiatr Brain Res 1:1–4

    Google Scholar 

  • Westarp ME, Bartmann P, Hoff-Jorgensen R, Clausen J, Rasmussen H, Kornhuber HH (1993a) Amyotrophe Lateralsklerose-Hinweise fur eine erhöhte antiretrovirale Seroreaktivitat ohne augenfallige Epidemiologie. Nervenarzt 64:384–389

    PubMed  CAS  Google Scholar 

  • Westarp ME, Fuchs D, Bartmann P, Hoff-Jorgensen R, Clausen J, Wachter H, Kornhuber HH (1993b) Amyotrophic lateral sclerosis an enigmatic disease with B-cellular and anti-retroviral immune responses. Eur J Med 2:327–332

    PubMed  CAS  Google Scholar 

  • Westarp ME, Westphal KP, Clausen J, Rasmussen HB, Hoff-Jorgensen R, Fohring B, Kornhuber HH (1993c) Retroviral interference with neuronotrophic signaling in human motor neuron disease? Clin Physiol Biochem 10.1–7

    PubMed  CAS  Google Scholar 

  • Westarp ME, Bartmann P, Rossler J, Geiger E, Westphal KP, Schreiber H, Fuchs D, Westarp MP, Kornhuber HH (1993d) Antiretroviral therapy in sporadic adult amyotrophic lateral sclerosis. Neuroreport 4:819–822

    Article  PubMed  CAS  Google Scholar 

  • Westarp ME, Foring B, Rasmussen H, Schraff S, Mertens T, Kornhuber HH (1994) Retroviral synthetic peptide serum antibodies in human sporadic amyotrophic lateral sclerosis. Peptides 15:207–214

    Article  PubMed  CAS  Google Scholar 

  • Wick G, Grubeck-Loebenstein B, Trieb K, Kalischnig G, Aguzzi A (1992) Human foamy virus antigens in thyroid tissue of Graves’ disease patients. Int Arch Allergy Immunol 99:153–156

    Article  PubMed  CAS  Google Scholar 

  • Wick G, Trieb K, Aguzzi A, Recheis H, Anderl H, Grubeck-Loebenstein B (1993) Pos-sible role of human foamy virus in Graves’ disease. Intervirology 35:101–107

    PubMed  CAS  Google Scholar 

  • Winkler IG, Löchelt M, Levesque JP, Bodem J, Flügel RM, Flowers RLP (1997) A rapid streptavidin-capture ELISA specific for the detection of antibodies to feline foamy virus. J Immunol Meth 207:69–77

    Article  CAS  Google Scholar 

  • Winkler IG, Flügel RM, Löchelt M, Flower RLP (1998) Detection and molecular characterization of feline foamy virus serotypes in naturally infected cats. Virology 247:144–151

    Article  PubMed  CAS  Google Scholar 

  • Winkler IG, Löchelt M, Flower RLP (1999) Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study. J Clin Micro 37:2848–2851

    CAS  Google Scholar 

  • Yanagawa T, Ito K, Kaplan EL, Ishikawa N, DeGroot LJ (1995) Absence of association between human spumaretrovirus and Graves’ disease. Thyroid 5:379–382

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. HIV and Retrovirology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G19, Atlanta, GA, 30333, USA

    W. Heneine & T. Folks

  2. Paul-Ehrlich-Institut, 63225, Langen, Germany

    M. Schweizer

  3. Bureau of HIV/AIDS, STD and TB, Health Canada, Ottawa, Canada

    P. Sandstrom

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  1. W. Heneine
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  2. M. Schweizer
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  3. P. Sandstrom
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  4. T. Folks
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Editors and Affiliations

  1. Medizinische Fakultät der TU Dresden, Institut für Virologie im MTZ, Fiedlerstr. 42, 01307, Dresden, Germany

    Axel Rethwilm

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Heneine, W., Schweizer, M., Sandstrom, P., Folks, T. (2003). Human Infection with Foamy Viruses. In: Rethwilm, A. (eds) Foamy Viruses. Current Topics in Microbiology and Immunology, vol 277. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55701-9_8

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  • DOI: https://doi.org/10.1007/978-3-642-55701-9_8

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