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Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues

  • H. P. Rodemann
Part of the Medical Radiology book series (MEDRAD)

Abstract

Over the years considerable effort has been made not only to quantify the tolerance of normal tissue to radiation, but also to provide a baseline for radiotherapy at maximum biological effective doses. Normal tissue complications induced by ionizing radiation differ depending on the target organ and cell types. Acute or early reactions are primarily characterized by rapidly occurring changes within hours, such as increased endothelial cell swelling, vascular permeability and edema as well as lymphocyte adhesion and infiltration. Apoptosis of endothelial cells is probably the most important feature in the concert of these radiation-induced acute alterations in the vascular system of irradiated organs. Thus, acute reactions are primarily reflected by the rates of radiation-induced cell death and regeneration by surviving stem cells.

Keywords

Radiat Oncol Biol Phys Radiat Biol Connective Tissue Remodel Cell Death Substrate Cancer Patient Undergo Radiation Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • H. P. Rodemann
    • 1
  1. 1.Section of Radiobiology and Molecular Environmental Research, Department of Radiation OncologyEberhard-Karls University, TübingenTübingenGermany

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