Potentially Malignant

  • George Laskaris
  • Crispian Scully


Erythroplasia (erythroplakia) is an isolated red lesion.


Smokeless Tobacco Verrucous Carcinoma Oral Leukoplakia Betel Quid Dent Assoc 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Reading List

  1. Alexander RE, Wright JM, Thiebaud S (2001) Evaluating, documenting and following up oral pathological conditions. A suggested protocol. J Am Dent Assoc 132:329–335Google Scholar
  2. Axell T, Holmstrup P, Kramer IRH, Pindborg JJ, Shear M (1984) International seminar on oralleukoplakia and associated lesions related to tobacco habits. Comm Dent Oral Epidemiol 12:145–154CrossRefGoogle Scholar
  3. Barrellier P, Babin E, Louis MY et al (1993) The use of toluidine blue in the diagnosis of neoplastic lesions of the oral cavity. Fr J Rev Stomatol Chir Maxillo-Faciale 944:51–54Google Scholar
  4. Batsakis JG, Suarez P, el-Naggar AK (1999) Proliferative verrucous leukoplakia and its related lesions. Oral Oncol 35:354–359PubMedCrossRefGoogle Scholar
  5. Chapman M (1988) Tobacco-induced changes: palatal gingiva. Gen Dent 36:54–60PubMedGoogle Scholar
  6. Craig RM Jr, Vickers VA, Correll RW (1989) Erythroplastic lesion on the mandibular marginal gingiva. J Am Dent Assoc 119:543–544PubMedGoogle Scholar
  7. Dufresne RG, Curlin MU (1997) Actinic cheilitis; a treatment review. Dermatol Surg 23:15–21PubMedCrossRefGoogle Scholar
  8. Epstein JB, Scully C, Spinelli J (1992) Toluidine blue and Lugol’s iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J Oral Pathol Med 21:160–163PubMedCrossRefGoogle Scholar
  9. Eversole LR, Eversole GM, Kopcik J (2000) Sanguinaria-associated oralleukoplakia: comparison with other benign and dysplastic leukoplakic lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:455–464PubMedCrossRefGoogle Scholar
  10. Gooris PJ, Roodenburg JL, Vermey A, Nauta JM (1999) Carbon dioxide laser evaporation of leukoplakia of the lower Hp: a retrospective evaluation. Oral Oncol 35:490–495PubMedCrossRefGoogle Scholar
  11. Grady D, Greene J, Daniels TE et al (1990) Oral mucosal lesions found in smokeless tobacco users. J Am Dent Assoc 121:117–123PubMedGoogle Scholar
  12. Hellden L, Jonsson R (1987). A papillary-verrucous lesion in the gingiva, developing into squamous cell carcinoma. J Clin Periodontol 14:56–61PubMedCrossRefGoogle Scholar
  13. Hogewind WFC, van der Kwast WAM, van der Waal I (1989) Oral leukoplakia with emphasis on malignant transformation: a follow-up study of 46 patients. J Craniomaxillofac Surg 17:128–133PubMedCrossRefGoogle Scholar
  14. Kabata K, Nakamura S, Ikemura K, Terashima H (1987) A case of erythroplakia of the palate, tongue and gingiva. I UOEH 9:341–345Google Scholar
  15. Kim I, Shin DM, El-Naggar A et al (2001) Chromosome polysomy and histological characteristics in oral premalignant lesions. Cancer Epidemiol 10:319–325Google Scholar
  16. Lee JJ, Hong WK, Hittelman WN, Mao L, Lotan R, Shin DM, Benner SE, Xu XC, Lee JS, Papadimitrakopoulou VM, Geyer C, Perez C, Martin JW, El-Naggar AK, Lippman SM (2000) Predicting cancer development in oral leukoplakia: ten years of translational research. Clin Cancer Res 6:1702–1710PubMedGoogle Scholar
  17. Lippman SM, Hong WK (2001) Molecular markers of the risk of oral cancer. N Engl J Med 344:1323–1326PubMedCrossRefGoogle Scholar
  18. Marley JJ, Linden GJ, Cowan CG, Lamey PI, Johnson NW, Warnakulasuriya KAAS, Scully C (1998) A comparison of the management of potentially malignant oral mucosal lesions by oral medicine specialists and oral and maxillofacial surgeons in the UK. J Oral Pathol Med 27:483–488Google Scholar
  19. Schoelch ML, Sekandari N, Regezi JA, Silverman S Jr (1999) Laser management of oral leukoplakias: a follow-up study of 70 patients. Laryngoscope 109:949–953PubMedCrossRefGoogle Scholar
  20. Sciubba J (1999) Improving detection ofprecancerous and cancerous orallesions: computer-assisted analysis of the oral brush biopsy. V.S. Collaborative Oral CDx Study Group. J Am Dent Assoc 130:1445–1457PubMedGoogle Scholar
  21. Scully C, Cawson RA (1996) Potentially malignant orallesions. J Epidemiol Biostatistics 1:3–12Google Scholar
  22. Scully C (1993) Clinical diagnostic methods for the detection of premalignant and early malignant orallesions. Comm Dent Health 1 [Suppl 1]:43–52Google Scholar
  23. Scully C (1995) Oral precancer: preventive and medical approaches to management. Oral Oncol Eur J Cancer Part B 131:16–26CrossRefGoogle Scholar
  24. Shafer WG, Waldron CA (1975) Erythroplakia of the oral cavity. Cancer 36:1021–1028PubMedCrossRefGoogle Scholar
  25. Silverman S Jr, Gorsky M, Lozada F (1984) Oral leukoplakia and malignant transformation: a follow-up study of 257 patients. Cancer 53:563–568PubMedCrossRefGoogle Scholar
  26. Sudbo J, Kildal W, Risberg B et al (2001) DNA content as a prognostic marker in patients with oralleukoplakia. N Engl J Med 344:1270–1278PubMedCrossRefGoogle Scholar
  27. Tradati N, Grigolat R, Calabrese L, Costa L, Giugliano G, Morelli F, Scully C, Boyle P, Chiesa F (1997) Oral leukoplakias: to treat or not? Oral Oncol 33:317–322PubMedCrossRefGoogle Scholar
  28. Van der Waal I, Schepman KP, van der Meij EH (2000) A modified classification and staging system for oral leukoplakia. Oral Oncol 36:264–266PubMedCrossRefGoogle Scholar
  29. World Health Organisation (1978) Collaborating centre for oral precancerous lesions. Definition of leukoplakia and related lesions: an aid to studies in oral precancer. Oral Surg 46:518–539Google Scholar
  30. Wright IM (1994) Oral precancerous lesions and conditions. Semin Dermatol 13:125–131PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • George Laskaris
    • 1
  • Crispian Scully
    • 2
  1. 1.Medical SchoolUniversity of AthensAthensGreece
  2. 2.Eastman Dental Institute for Oral Health Care SciencesUniversity College LondonLondonUK

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